IL42868A - Pharmaceutical compositions having synergistic analgesic activity and containing a 6-azido-morphine derivative and either a 4-oxopyrido (1,2-alpha)-pyrimidine-3-carboxylic acid derivative or a butyrophenone derivative - Google Patents
Pharmaceutical compositions having synergistic analgesic activity and containing a 6-azido-morphine derivative and either a 4-oxopyrido (1,2-alpha)-pyrimidine-3-carboxylic acid derivative or a butyrophenone derivativeInfo
- Publication number
- IL42868A IL42868A IL42868A IL4286873A IL42868A IL 42868 A IL42868 A IL 42868A IL 42868 A IL42868 A IL 42868A IL 4286873 A IL4286873 A IL 4286873A IL 42868 A IL42868 A IL 42868A
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutical composition
- derivative
- homopyrimidazolium
- tetrahydro
- oxo
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 10
- 230000000202 analgesic effect Effects 0.000 title claims 3
- 230000002195 synergetic effect Effects 0.000 title claims 3
- RLKSQLJFGCDUOX-UHFFFAOYSA-N 1-(4-tert-butylphenyl)-4-chlorobutan-1-one Chemical compound CC(C)(C)C1=CC=C(C(=O)CCCCl)C=C1 RLKSQLJFGCDUOX-UHFFFAOYSA-N 0.000 title claims 2
- YKUYPQRCZHZIQJ-QOOGKBTOSA-N [(4r,4ar,7s,7ar,12bs)-7,9-dihydroxy-3-methyl-1,2,4,4a,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-diazonioazanide Chemical class O([C@H]1[C@](C=C[C@H]23)(O)[N-][N+]#N)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O YKUYPQRCZHZIQJ-QOOGKBTOSA-N 0.000 title 1
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- HHODTHJTFYCYHK-KEMUOJQUSA-N (4r,4ar,7r,7ar,12bs)-7-azido-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@@H](N=[N+]=[N-])[C@@H]1OC1=C2C3=CC=C1OC HHODTHJTFYCYHK-KEMUOJQUSA-N 0.000 claims 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-M 3-carboxy-2,3-dihydroxypropanoate Chemical compound OC(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-M 0.000 claims 3
- KZOKOEQTKWBKOK-XHQKLZHNSA-N azidomorphine Chemical compound O([C@H]1[C@@H](CC[C@H]23)N=[N+]=[N-])C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O KZOKOEQTKWBKOK-XHQKLZHNSA-N 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000003708 ampul Substances 0.000 claims 1
- 229940054053 antipsychotics butyrophenone derivative Drugs 0.000 claims 1
- -1 azido compound Chemical class 0.000 claims 1
- FFSAXUULYPJSKH-UHFFFAOYSA-N butyrophenone Chemical class CCCC(=O)C1=CC=CC=C1 FFSAXUULYPJSKH-UHFFFAOYSA-N 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001064 morpholinomethyl group Chemical group [H]C([H])(*)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUCI001259 HU165505B (enrdf_load_stackoverflow) | 1972-08-03 | 1972-08-03 | |
| HUCI1322A HU166378B (enrdf_load_stackoverflow) | 1972-12-19 | 1972-12-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL42868A0 IL42868A0 (en) | 1973-11-28 |
| IL42868A true IL42868A (en) | 1976-04-30 |
Family
ID=26318390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42868A IL42868A (en) | 1972-08-03 | 1973-08-01 | Pharmaceutical compositions having synergistic analgesic activity and containing a 6-azido-morphine derivative and either a 4-oxopyrido (1,2-alpha)-pyrimidine-3-carboxylic acid derivative or a butyrophenone derivative |
Country Status (7)
| Country | Link |
|---|---|
| CA (1) | CA1010789A (enrdf_load_stackoverflow) |
| CS (1) | CS184414B1 (enrdf_load_stackoverflow) |
| DE (1) | DE2338901C2 (enrdf_load_stackoverflow) |
| FR (1) | FR2194444B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1396663A (enrdf_load_stackoverflow) |
| IL (1) | IL42868A (enrdf_load_stackoverflow) |
| SE (1) | SE422272B (enrdf_load_stackoverflow) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT296996B (de) * | 1966-11-02 | 1972-03-10 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur Herstellung von Homopyrimidazolderivaten und deren Säureadditionssalzen und quaternären Ammoniumsalzen |
-
1973
- 1973-08-01 SE SE7310620A patent/SE422272B/xx unknown
- 1973-08-01 DE DE2338901A patent/DE2338901C2/de not_active Expired
- 1973-08-01 IL IL42868A patent/IL42868A/en unknown
- 1973-08-02 CS CS7300005502A patent/CS184414B1/cs unknown
- 1973-08-02 GB GB3687373A patent/GB1396663A/en not_active Expired
- 1973-08-02 CA CA178,023A patent/CA1010789A/en not_active Expired
- 1973-08-03 FR FR7328463A patent/FR2194444B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2338901C2 (de) | 1984-01-26 |
| IL42868A0 (en) | 1973-11-28 |
| GB1396663A (en) | 1975-06-04 |
| SE7310620L (enrdf_load_stackoverflow) | 1974-02-04 |
| FR2194444B1 (enrdf_load_stackoverflow) | 1976-08-13 |
| SE422272B (sv) | 1982-03-01 |
| DE2338901A1 (de) | 1974-02-21 |
| CA1010789A (en) | 1977-05-24 |
| CS184414B1 (en) | 1978-08-31 |
| FR2194444A1 (enrdf_load_stackoverflow) | 1974-03-01 |
| AU5875873A (en) | 1975-02-06 |
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