GB1396663A - Analgesic compositions - Google Patents

Info

Publication number

GB1396663A

GB1396663A GB3687373A GB3687373A GB1396663A GB 1396663 A GB1396663 A GB 1396663A GB 3687373 A GB3687373 A GB 3687373A GB 3687373 A GB3687373 A GB 3687373A GB 1396663 A GB1396663 A GB 1396663A

Authority

GB

United Kingdom

Prior art keywords

formula

compound

pharmaceutically acceptable

butyrophenone

morphine

Prior art date

1972-08-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

• Espacenet
• Global Dossier
• Discuss

• 230000000202 analgesic effect Effects 0.000 title abstract 3
• 239000000203 mixture Substances 0.000 title abstract 2
• 150000001875 compounds Chemical class 0.000 abstract 4
• 150000003839 salts Chemical class 0.000 abstract 3
• 229910052739 hydrogen Inorganic materials 0.000 abstract 2
• 239000001257 hydrogen Substances 0.000 abstract 2
• 239000006187 pill Substances 0.000 abstract 2
• PINJWULOJPTEBH-HIFDQRORSA-N (4R,4aR,7S,7aR,12bS)-7a-azido-3-methyl-9-(morpholin-4-ylmethoxy)-1,2,4,4a,7,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol Chemical compound C([C@@]1([C@@H]2C=C[C@H](O)[C@]3(N=[N+]=[N-])OC4=C5[C@@]32CCN1C)[H])C5=CC=C4OCN1CCOCC1 PINJWULOJPTEBH-HIFDQRORSA-N 0.000 abstract 1
• HHODTHJTFYCYHK-KEMUOJQUSA-N (4r,4ar,7r,7ar,12bs)-7-azido-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@@H](N=[N+]=[N-])[C@@H]1OC1=C2C3=CC=C1OC HHODTHJTFYCYHK-KEMUOJQUSA-N 0.000 abstract 1
• QLAJNZSPVITUCQ-UHFFFAOYSA-N 1,3,2-dioxathietane 2,2-dioxide Chemical compound O=S1(=O)OCO1 QLAJNZSPVITUCQ-UHFFFAOYSA-N 0.000 abstract 1
• RLKSQLJFGCDUOX-UHFFFAOYSA-N 1-(4-tert-butylphenyl)-4-chlorobutan-1-one Chemical compound CC(C)(C)C1=CC=C(C(=O)CCCCl)C=C1 RLKSQLJFGCDUOX-UHFFFAOYSA-N 0.000 abstract 1
• SYYJAVGEIIHKEI-LEPYJNQMSA-N 2-[[(4r,4ar,7s,7ar,12bs)-7-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-9-yl]oxy]ethyl-diazonioazanide Chemical compound O[C@H]([C@@H]1O2)C=C[C@H]3[C@]4([H])N(C)CC[C@]13C1=C2C(OCCN=[N+]=[N-])=CC=C1C4 SYYJAVGEIIHKEI-LEPYJNQMSA-N 0.000 abstract 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-M 3-carboxy-2,3-dihydroxypropanoate Chemical class OC(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-M 0.000 abstract 1
• CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
• 229910002651 NO3 Inorganic materials 0.000 abstract 1
• NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
• CJBOZUSNLOSNNO-WMRVMTBBSA-N [(4R,4aR,7S,7aR,12bS)-7-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl] 2-azidoacetate Chemical compound O[C@H]([C@@H]1O2)C=C[C@H]3[C@]4([H])N(C)CC[C@]13C1=C2C(OC(=O)CN=[N+]=[N-])=CC=C1C4 CJBOZUSNLOSNNO-WMRVMTBBSA-N 0.000 abstract 1
• 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
• 125000000217 alkyl group Chemical group 0.000 abstract 1
• 229940035676 analgesics Drugs 0.000 abstract 1
• 239000000730 antalgic agent Substances 0.000 abstract 1
• 229940054053 antipsychotics butyrophenone derivative Drugs 0.000 abstract 1
• -1 azido compound Chemical class 0.000 abstract 1
• KZOKOEQTKWBKOK-XHQKLZHNSA-N azidomorphine Chemical compound O([C@H]1[C@@H](CC[C@H]23)N=[N+]=[N-])C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O KZOKOEQTKWBKOK-XHQKLZHNSA-N 0.000 abstract 1
• FFSAXUULYPJSKH-UHFFFAOYSA-N butyrophenone Chemical class CCCC(=O)C1=CC=CC=C1 FFSAXUULYPJSKH-UHFFFAOYSA-N 0.000 abstract 1
• 239000002775 capsule Substances 0.000 abstract 1
• 239000003085 diluting agent Substances 0.000 abstract 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
• KIWBPDUYBMNFTB-UHFFFAOYSA-M ethyl sulfate Chemical compound CCOS([O-])(=O)=O KIWBPDUYBMNFTB-UHFFFAOYSA-M 0.000 abstract 1
• 150000002431 hydrogen Chemical group 0.000 abstract 1
• 239000007788 liquid Substances 0.000 abstract 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
• JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 abstract 1
• 125000001064 morpholinomethyl group Chemical group [H]C([H])(*)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 abstract 1
• 239000008194 pharmaceutical composition Substances 0.000 abstract 1
• DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 abstract 1
• 239000000843 powder Substances 0.000 abstract 1
• 238000002360 preparation method Methods 0.000 abstract 1
• 239000007787 solid Substances 0.000 abstract 1
• 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
• 230000002195 synergetic effect Effects 0.000 abstract 1
• 239000003826 tablet Substances 0.000 abstract 1