IL40281A - 1h-1,4-benzodiazepine derivatives,their manufacture and pharmaceutical compositions containing them - Google Patents
1h-1,4-benzodiazepine derivatives,their manufacture and pharmaceutical compositions containing themInfo
- Publication number
- IL40281A IL40281A IL40281A IL4028172A IL40281A IL 40281 A IL40281 A IL 40281A IL 40281 A IL40281 A IL 40281A IL 4028172 A IL4028172 A IL 4028172A IL 40281 A IL40281 A IL 40281A
- Authority
- IL
- Israel
- Prior art keywords
- benzodiazepine
- represents hydrogen
- formula
- halogen
- benzodiazepine derivatives
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical class N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000000034 method Methods 0.000 claims 21
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 claims 11
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000002253 acid Substances 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 5
- 229910052801 chlorine Inorganic materials 0.000 claims 5
- 239000000460 chlorine Substances 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 229940049706 benzodiazepine Drugs 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 239000003960 organic solvent Substances 0.000 claims 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 229940100198 alkylating agent Drugs 0.000 claims 2
- 239000002168 alkylating agent Substances 0.000 claims 2
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 2
- 150000004965 peroxy acids Chemical class 0.000 claims 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical group N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical group CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 1
- 241000282320 Panthera leo Species 0.000 claims 1
- 241001061127 Thione Species 0.000 claims 1
- MZVQCMJNVPIDEA-UHFFFAOYSA-N [CH2]CN(CC)CC Chemical group [CH2]CN(CC)CC MZVQCMJNVPIDEA-UHFFFAOYSA-N 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- -1 alkali metal salt Chemical class 0.000 claims 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 230000002082 anti-convulsion Effects 0.000 claims 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 claims 1
- 230000003009 desulfurizing effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004705 ethylthio group Chemical group C(C)S* 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 125000005905 mesyloxy group Chemical group 0.000 claims 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000003158 myorelaxant agent Substances 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 150000002978 peroxides Chemical class 0.000 claims 1
- 230000001624 sedative effect Effects 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 125000005424 tosyloxy group Chemical group S(=O)(=O)(C1=CC=C(C)C=C1)O* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/22—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00187836A US3836521A (en) | 1971-10-08 | 1971-10-08 | 2-lower alkylthio-1h-1,4-benzodiazepines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL40281A0 IL40281A0 (en) | 1972-11-28 |
| IL40281A true IL40281A (en) | 1976-02-29 |
Family
ID=22690672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL40281A IL40281A (en) | 1971-10-08 | 1972-09-01 | 1h-1,4-benzodiazepine derivatives,their manufacture and pharmaceutical compositions containing them |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3836521A (de) |
| JP (1) | JPS4844290A (de) |
| AT (1) | AT327911B (de) |
| AU (1) | AU472124B2 (de) |
| BE (1) | BE789757A (de) |
| CA (1) | CA990721A (de) |
| CH (1) | CH575933A5 (de) |
| DE (1) | DE2249447A1 (de) |
| FR (1) | FR2158211B1 (de) |
| GB (1) | GB1360296A (de) |
| IL (1) | IL40281A (de) |
| NL (1) | NL7213555A (de) |
| SE (1) | SE400765B (de) |
| ZA (1) | ZA725964B (de) |
-
0
- BE BE789757D patent/BE789757A/xx unknown
-
1971
- 1971-10-08 US US00187836A patent/US3836521A/en not_active Expired - Lifetime
-
1972
- 1972-08-30 ZA ZA725964A patent/ZA725964B/xx unknown
- 1972-09-01 IL IL40281A patent/IL40281A/en unknown
- 1972-09-01 AU AU46249/72A patent/AU472124B2/en not_active Expired
- 1972-09-22 CH CH1386072A patent/CH575933A5/xx not_active IP Right Cessation
- 1972-10-04 JP JP47099724A patent/JPS4844290A/ja active Pending
- 1972-10-04 CA CA153,179A patent/CA990721A/en not_active Expired
- 1972-10-06 FR FR7235559A patent/FR2158211B1/fr not_active Expired
- 1972-10-06 AT AT857972A patent/AT327911B/de not_active IP Right Cessation
- 1972-10-06 GB GB4623872A patent/GB1360296A/en not_active Expired
- 1972-10-06 NL NL7213555A patent/NL7213555A/xx not_active Application Discontinuation
- 1972-10-06 SE SE7212978A patent/SE400765B/xx unknown
- 1972-10-09 DE DE2249447A patent/DE2249447A1/de active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE2249447A1 (de) | 1973-04-12 |
| CH575933A5 (de) | 1976-05-31 |
| ZA725964B (en) | 1973-05-30 |
| GB1360296A (en) | 1974-07-17 |
| AU4624972A (en) | 1974-03-07 |
| AT327911B (de) | 1976-02-25 |
| SE400765B (sv) | 1978-04-10 |
| US3836521A (en) | 1974-09-17 |
| FR2158211A1 (de) | 1973-06-15 |
| NL7213555A (de) | 1973-04-10 |
| CA990721A (en) | 1976-06-08 |
| ATA857972A (de) | 1975-05-15 |
| FR2158211B1 (de) | 1975-10-31 |
| JPS4844290A (de) | 1973-06-26 |
| BE789757A (fr) | 1973-04-06 |
| AU472124B2 (en) | 1976-05-20 |
| IL40281A0 (en) | 1972-11-28 |
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