IL325760A - תולדות 2-(1h-אינדול-4-איל)מתיל) -איזואינדולין כמעכבי פקטור b - Google Patents
תולדות 2-(1h-אינדול-4-איל)מתיל) -איזואינדולין כמעכבי פקטור bInfo
- Publication number
- IL325760A IL325760A IL325760A IL32576026A IL325760A IL 325760 A IL325760 A IL 325760A IL 325760 A IL325760 A IL 325760A IL 32576026 A IL32576026 A IL 32576026A IL 325760 A IL325760 A IL 325760A
- Authority
- IL
- Israel
- Prior art keywords
- indol
- inhibitors
- methyl
- factor
- isoindoline derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2310221.3A GB202310221D0 (en) | 2023-07-04 | 2023-07-04 | Novel compounds |
| GBGB2316973.3A GB202316973D0 (en) | 2023-11-06 | 2023-11-06 | Novel compounds |
| GBGB2403997.6A GB202403997D0 (en) | 2024-03-20 | 2024-03-20 | Novel compounds |
| PCT/EP2024/068846 WO2025008453A1 (en) | 2023-07-04 | 2024-07-04 | 2-(1h-indol-4-yl)methyl)-isoindoline derivatives as factor b inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL325760A true IL325760A (he) | 2026-03-01 |
Family
ID=91856031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL325760A IL325760A (he) | 2023-07-04 | 2024-07-04 | תולדות 2-(1h-אינדול-4-איל)מתיל) -איזואינדולין כמעכבי פקטור b |
Country Status (5)
| Country | Link |
|---|---|
| KR (1) | KR20260049193A (he) |
| CN (1) | CN121752557A (he) |
| AU (1) | AU2024290587A1 (he) |
| IL (1) | IL325760A (he) |
| WO (1) | WO2025008453A1 (he) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025172535A1 (en) | 2024-02-15 | 2025-08-21 | Sitala Bio Ltd | Indole and benzimidazole compounds as factor b inhibitors |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA027113B1 (ru) | 2012-05-04 | 2017-06-30 | Новартис Аг | Регуляторы пути комплемента и их применение |
| US9056874B2 (en) | 2012-05-04 | 2015-06-16 | Novartis Ag | Complement pathway modulators and uses thereof |
| US9475806B2 (en) | 2013-03-14 | 2016-10-25 | Novartis Ag | Complement factor B inhibitors and uses there of |
| JO3425B1 (ar) | 2013-07-15 | 2019-10-20 | Novartis Ag | مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b |
| KR20230049115A (ko) | 2020-08-07 | 2023-04-12 | 상하이 메이유에 바이오테크 디벨롭먼트 컴퍼니 리미티드 | 보체 인자 b 억제제 및 이의 약학적 조성물, 제조 방법 및 용도 |
| WO2022028507A1 (zh) | 2020-08-07 | 2022-02-10 | 上海美悦生物科技发展有限公司 | 一种杂环类化合物、其制备方法及用途 |
| CA3203320A1 (en) | 2020-12-30 | 2022-07-07 | Xin Li | Nitrogen-containing bridged heterocyclic compound, preparation method therefor, and medical use thereof |
| AU2021414253B2 (en) | 2020-12-30 | 2024-05-16 | Shanghai Fosun Pharmaceutical Industrial Development Co., Ltd. | Series of piperidine-substituted benzoic acid compounds, and use thereof |
| CN116848238A (zh) | 2021-01-14 | 2023-10-03 | 阿雷克森制药公司 | 大环补体因子b抑制剂 |
| US20240217953A1 (en) | 2021-04-16 | 2024-07-04 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Bicyclic substituted aromatic carboxylic acid compounds |
| CN120081822A (zh) | 2021-06-03 | 2025-06-03 | 诺瓦提斯药物公司 | 经取代的吲哚化合物及其使用方法 |
| EP4362933A4 (en) | 2021-06-30 | 2025-06-04 | Apellis Pharmaceuticals, Inc. | COMPLEMENT INHIBITION |
| US11891731B2 (en) | 2021-08-10 | 2024-02-06 | Southern Mills, Inc. | Flame resistant fabrics |
| EP4389742A4 (en) | 2021-08-18 | 2026-01-14 | Xizang Haisco Pharmaceutical Co Ltd | HETEROAROMATIC CYCLE DERIVATIVE CONTAINING BENZO NITROGEN AND ITS USE IN MEDICINE |
| TW202334121A (zh) | 2021-10-27 | 2023-09-01 | 美商翰森生物有限責任公司 | 哌啶基吲哚衍生物、其製備方法及醫藥用途 |
| CA3247772A1 (en) | 2022-01-24 | 2023-07-27 | Novartis Ag | Spirocyclic piperidinyl derivatives as complement factor B inhibitors and their uses |
| TW202423426A (zh) | 2022-08-31 | 2024-06-16 | 美商奇努克醫療股份有限公司 | 經取代之吲哚化合物及其使用方法 |
-
2024
- 2024-07-04 IL IL325760A patent/IL325760A/he unknown
- 2024-07-04 CN CN202480056130.9A patent/CN121752557A/zh active Pending
- 2024-07-04 WO PCT/EP2024/068846 patent/WO2025008453A1/en not_active Ceased
- 2024-07-04 KR KR1020267003686A patent/KR20260049193A/ko active Pending
- 2024-07-04 AU AU2024290587A patent/AU2024290587A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2025008453A1 (en) | 2025-01-09 |
| KR20260049193A (ko) | 2026-04-13 |
| AU2024290587A1 (en) | 2026-02-19 |
| CN121752557A (zh) | 2026-03-27 |
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