IL325759A - תולדות 2-(1h-אינדול-4-איל)מתיל)2h-אינדאזול כמעכבי פקטור b - Google Patents
תולדות 2-(1h-אינדול-4-איל)מתיל)2h-אינדאזול כמעכבי פקטור bInfo
- Publication number
- IL325759A IL325759A IL325759A IL32575926A IL325759A IL 325759 A IL325759 A IL 325759A IL 325759 A IL325759 A IL 325759A IL 32575926 A IL32575926 A IL 32575926A IL 325759 A IL325759 A IL 325759A
- Authority
- IL
- Israel
- Prior art keywords
- indol
- inhibitors
- methyl
- factor
- indazole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2310218.9A GB202310218D0 (en) | 2023-07-04 | 2023-07-04 | Novel compounds |
| GBGB2316972.5A GB202316972D0 (en) | 2023-11-06 | 2023-11-06 | Novel compounds |
| GBGB2403995.0A GB202403995D0 (en) | 2024-03-20 | 2024-03-20 | Novel compounds |
| PCT/EP2024/068840 WO2025008451A1 (en) | 2023-07-04 | 2024-07-04 | 2-(1h-indol-4-yl)methyl)2h-indazole derivatives as factor b inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL325759A true IL325759A (he) | 2026-03-01 |
Family
ID=91856306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL325759A IL325759A (he) | 2023-07-04 | 2024-07-04 | תולדות 2-(1h-אינדול-4-איל)מתיל)2h-אינדאזול כמעכבי פקטור b |
Country Status (5)
| Country | Link |
|---|---|
| KR (1) | KR20260049192A (he) |
| CN (1) | CN121889385A (he) |
| AU (1) | AU2024291322A1 (he) |
| IL (1) | IL325759A (he) |
| WO (1) | WO2025008451A1 (he) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025172535A1 (en) | 2024-02-15 | 2025-08-21 | Sitala Bio Ltd | Indole and benzimidazole compounds as factor b inhibitors |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102315D0 (sv) * | 2001-06-28 | 2001-06-28 | Astrazeneca Ab | Compounds |
| CN101687009A (zh) | 2007-05-11 | 2010-03-31 | 宾夕法尼亚大学理事会 | 治疗皮肤溃疡的方法 |
| US9056874B2 (en) | 2012-05-04 | 2015-06-16 | Novartis Ag | Complement pathway modulators and uses thereof |
| EA027113B1 (ru) | 2012-05-04 | 2017-06-30 | Новартис Аг | Регуляторы пути комплемента и их применение |
| US9475806B2 (en) | 2013-03-14 | 2016-10-25 | Novartis Ag | Complement factor B inhibitors and uses there of |
| JO3425B1 (ar) | 2013-07-15 | 2019-10-20 | Novartis Ag | مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b |
| CN120118068A (zh) | 2018-07-16 | 2025-06-10 | 诺华股份有限公司 | 用于制备苯基哌啶基吲哚衍生物的化学方法 |
| KR20230049115A (ko) | 2020-08-07 | 2023-04-12 | 상하이 메이유에 바이오테크 디벨롭먼트 컴퍼니 리미티드 | 보체 인자 b 억제제 및 이의 약학적 조성물, 제조 방법 및 용도 |
| WO2022028507A1 (zh) | 2020-08-07 | 2022-02-10 | 上海美悦生物科技发展有限公司 | 一种杂环类化合物、其制备方法及用途 |
| CA3203320A1 (en) | 2020-12-30 | 2022-07-07 | Xin Li | Nitrogen-containing bridged heterocyclic compound, preparation method therefor, and medical use thereof |
| AU2021414253B2 (en) | 2020-12-30 | 2024-05-16 | Shanghai Fosun Pharmaceutical Industrial Development Co., Ltd. | Series of piperidine-substituted benzoic acid compounds, and use thereof |
| CN116848238A (zh) | 2021-01-14 | 2023-10-03 | 阿雷克森制药公司 | 大环补体因子b抑制剂 |
| US20240217953A1 (en) | 2021-04-16 | 2024-07-04 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Bicyclic substituted aromatic carboxylic acid compounds |
| CN120081822A (zh) | 2021-06-03 | 2025-06-03 | 诺瓦提斯药物公司 | 经取代的吲哚化合物及其使用方法 |
| EP4362933A4 (en) | 2021-06-30 | 2025-06-04 | Apellis Pharmaceuticals, Inc. | COMPLEMENT INHIBITION |
| EP4389742A4 (en) | 2021-08-18 | 2026-01-14 | Xizang Haisco Pharmaceutical Co Ltd | HETEROAROMATIC CYCLE DERIVATIVE CONTAINING BENZO NITROGEN AND ITS USE IN MEDICINE |
| TW202334121A (zh) | 2021-10-27 | 2023-09-01 | 美商翰森生物有限責任公司 | 哌啶基吲哚衍生物、其製備方法及醫藥用途 |
| CA3247772A1 (en) | 2022-01-24 | 2023-07-27 | Novartis Ag | Spirocyclic piperidinyl derivatives as complement factor B inhibitors and their uses |
| UY40204A (es) | 2022-04-01 | 2023-10-31 | Novartis Ag | Inhibidores del Factor B del Complemento y Usos de los mismos |
| TW202423426A (zh) | 2022-08-31 | 2024-06-16 | 美商奇努克醫療股份有限公司 | 經取代之吲哚化合物及其使用方法 |
-
2024
- 2024-07-04 CN CN202480055540.1A patent/CN121889385A/zh active Pending
- 2024-07-04 WO PCT/EP2024/068840 patent/WO2025008451A1/en not_active Ceased
- 2024-07-04 AU AU2024291322A patent/AU2024291322A1/en active Pending
- 2024-07-04 IL IL325759A patent/IL325759A/he unknown
- 2024-07-04 KR KR1020267003685A patent/KR20260049192A/ko active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN121889385A (zh) | 2026-04-17 |
| AU2024291322A1 (en) | 2026-02-19 |
| KR20260049192A (ko) | 2026-04-13 |
| WO2025008451A1 (en) | 2025-01-09 |
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