IL324246A - סינתזת אוליגונוקלאוטידים באמצעות נוקלאוזידים מחזוריים-פוספוריים - Google Patents
סינתזת אוליגונוקלאוטידים באמצעות נוקלאוזידים מחזוריים-פוספורייםInfo
- Publication number
- IL324246A IL324246A IL324246A IL32424625A IL324246A IL 324246 A IL324246 A IL 324246A IL 324246 A IL324246 A IL 324246A IL 32424625 A IL32424625 A IL 32424625A IL 324246 A IL324246 A IL 324246A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- ref
- hydrogen
- dinucleotide
- certain embodiments
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202363500726P | 2023-05-08 | 2023-05-08 | |
| EP24382484 | 2024-05-03 | ||
| PCT/US2024/028291 WO2024233624A1 (en) | 2023-05-08 | 2024-05-08 | Oligonucleotide synthesis using cyclic-phosphorous nucleosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL324246A true IL324246A (he) | 2025-12-01 |
Family
ID=91274520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL324246A IL324246A (he) | 2023-05-08 | 2025-10-27 | סינתזת אוליגונוקלאוטידים באמצעות נוקלאוזידים מחזוריים-פוספוריים |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP4709735A1 (he) |
| JP (1) | JP2026517877A (he) |
| KR (1) | KR20250177459A (he) |
| CN (1) | CN121443620A (he) |
| AU (1) | AU2024270006A1 (he) |
| IL (1) | IL324246A (he) |
| TW (2) | TW202539695A (he) |
| WO (1) | WO2024233624A1 (he) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6251695A (ja) * | 1985-08-29 | 1987-03-06 | Yuki Gosei Yakuhin Kogyo Kk | ホスホロアミダイト類の合成法 |
| AU2003242672B2 (en) * | 2002-06-07 | 2009-12-17 | Universitair Medisch Centrum Utrecht | New compounds for modulating the activity of exhange proteins directly activated by camp (EPACS) |
| US8927513B2 (en) | 2009-07-07 | 2015-01-06 | Alnylam Pharmaceuticals, Inc. | 5′ phosphate mimics |
| US9725479B2 (en) | 2010-04-22 | 2017-08-08 | Ionis Pharmaceuticals, Inc. | 5′-end derivatives |
| WO2014124430A1 (en) * | 2013-02-11 | 2014-08-14 | Emory University | Nucleotide and nucleoside therapeutic compositions and uses related thereto |
| WO2018045317A1 (en) | 2016-09-02 | 2018-03-08 | Dicerna Pharmaceuticals, Inc. | 4'-phosphate analogs and oligonucleotides comprising the same |
| US20240294565A1 (en) * | 2021-05-17 | 2024-09-05 | Ligand Pharmaceuticals Incorporated | Unnatural configuration nucleotide prodrug compounds |
-
2024
- 2024-05-08 TW TW114119874A patent/TW202539695A/zh unknown
- 2024-05-08 EP EP24728847.5A patent/EP4709735A1/en active Pending
- 2024-05-08 CN CN202480044598.6A patent/CN121443620A/zh active Pending
- 2024-05-08 AU AU2024270006A patent/AU2024270006A1/en active Pending
- 2024-05-08 JP JP2025564955A patent/JP2026517877A/ja active Pending
- 2024-05-08 WO PCT/US2024/028291 patent/WO2024233624A1/en not_active Ceased
- 2024-05-08 TW TW113117048A patent/TWI904659B/zh active
- 2024-05-08 KR KR1020257040468A patent/KR20250177459A/ko active Pending
-
2025
- 2025-10-27 IL IL324246A patent/IL324246A/he unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2026517877A (ja) | 2026-06-02 |
| TW202539695A (zh) | 2025-10-16 |
| AU2024270006A1 (en) | 2025-11-13 |
| TW202508604A (zh) | 2025-03-01 |
| CN121443620A (zh) | 2026-01-30 |
| KR20250177459A (ko) | 2025-12-23 |
| EP4709735A1 (en) | 2026-03-18 |
| WO2024233624A1 (en) | 2024-11-14 |
| TWI904659B (zh) | 2025-11-11 |
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