IL303650B2 - Stable group 2 trimers from the stem region of influenza hemagglutinin and their uses - Google Patents

Stable group 2 trimers from the stem region of influenza hemagglutinin and their uses

Info

Publication number
IL303650B2
IL303650B2 IL303650A IL30365023A IL303650B2 IL 303650 B2 IL303650 B2 IL 303650B2 IL 303650 A IL303650 A IL 303650A IL 30365023 A IL30365023 A IL 30365023A IL 303650 B2 IL303650 B2 IL 303650B2
Authority
IL
Israel
Prior art keywords
protein
amino acid
influenza
seq
acid sequence
Prior art date
Application number
IL303650A
Other languages
English (en)
Hebrew (he)
Other versions
IL303650A (en
IL303650B1 (en
Inventor
Jeffrey C Boyington
Barney S Graham
John R Mascola
Hadi M Yassine
Kizzmekia S Corbett
Syed M Moin
Lingshu Wang
Masaru Kanekiyo
Original Assignee
Us Health
Jeffrey C Boyington
Barney S Graham
John R Mascola
Hadi M Yassine
Kizzmekia S Corbett
Syed M Moin
Lingshu Wang
Masaru Kanekiyo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health, Jeffrey C Boyington, Barney S Graham, John R Mascola, Hadi M Yassine, Kizzmekia S Corbett, Syed M Moin, Lingshu Wang, Masaru Kanekiyo filed Critical Us Health
Publication of IL303650A publication Critical patent/IL303650A/en
Publication of IL303650B1 publication Critical patent/IL303650B1/en
Publication of IL303650B2 publication Critical patent/IL303650B2/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346Nanoparticles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/35Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/42Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/11Orthomyxoviridae, e.g. influenza virus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/20Detection of antibodies in sample from host which are directed against antigens from microorganisms

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nanotechnology (AREA)
IL303650A 2016-09-02 2017-09-01 Stable group 2 trimers from the stem region of influenza hemagglutinin and their uses IL303650B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662383267P 2016-09-02 2016-09-02
PCT/US2017/049894 WO2018045308A1 (en) 2016-09-02 2017-09-01 Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof

Publications (3)

Publication Number Publication Date
IL303650A IL303650A (en) 2023-08-01
IL303650B1 IL303650B1 (en) 2024-10-01
IL303650B2 true IL303650B2 (en) 2025-02-01

Family

ID=59887401

Family Applications (3)

Application Number Title Priority Date Filing Date
IL303650A IL303650B2 (en) 2016-09-02 2017-09-01 Stable group 2 trimers from the stem region of influenza hemagglutinin and their uses
IL315821A IL315821A (en) 2016-09-02 2017-09-01 Group 2 stable trimers of the stem region of influenza hemagglutinin and their uses
IL265121A IL265121B2 (en) 2016-09-02 2017-09-01 Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL315821A IL315821A (en) 2016-09-02 2017-09-01 Group 2 stable trimers of the stem region of influenza hemagglutinin and their uses
IL265121A IL265121B2 (en) 2016-09-02 2017-09-01 Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof

Country Status (11)

Country Link
US (3) US11338033B2 (cg-RX-API-DMAC7.html)
EP (1) EP3506938A1 (cg-RX-API-DMAC7.html)
JP (3) JP7183149B2 (cg-RX-API-DMAC7.html)
KR (2) KR20240042570A (cg-RX-API-DMAC7.html)
CN (2) CN110167585B (cg-RX-API-DMAC7.html)
AU (2) AU2017321883B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019004189A2 (cg-RX-API-DMAC7.html)
CA (1) CA3035443A1 (cg-RX-API-DMAC7.html)
IL (3) IL303650B2 (cg-RX-API-DMAC7.html)
SG (2) SG11201901790YA (cg-RX-API-DMAC7.html)
WO (1) WO2018045308A1 (cg-RX-API-DMAC7.html)

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WO2021174132A2 (en) * 2020-02-26 2021-09-02 The Wistar Institute Of Anatomy & Biology Compositions comprising self-assembling vaccines and methods of using the same
CN111560074B (zh) * 2020-03-20 2021-07-09 中山大学 一种基于幽门螺旋杆菌铁蛋白的新型冠状病毒s蛋白单区域亚单位纳米疫苗
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IL315821A (en) 2024-11-01
IL265121B1 (en) 2023-07-01
AU2022246465B2 (en) 2024-05-30
BR112019004189A2 (pt) 2019-06-25
AU2017321883B2 (en) 2022-07-07
US20190192651A1 (en) 2019-06-27
SG11201901790YA (en) 2019-03-28
US20240050554A1 (en) 2024-02-15
JP2019537424A (ja) 2019-12-26
CN118146389A (zh) 2024-06-07
KR20240042570A (ko) 2024-04-02
CN110167585A (zh) 2019-08-23
EP3506938A1 (en) 2019-07-10
JP7500692B2 (ja) 2024-06-17
IL303650A (en) 2023-08-01
IL265121B2 (en) 2023-11-01
SG10201912944QA (en) 2020-02-27
KR20190056382A (ko) 2019-05-24
CN110167585B (zh) 2024-03-08
JP7183149B2 (ja) 2022-12-05
AU2022246465A1 (en) 2022-11-17
WO2018045308A1 (en) 2018-03-08
US20220339278A1 (en) 2022-10-27
AU2017321883A1 (en) 2019-04-18
JP2023018073A (ja) 2023-02-07
US11793871B2 (en) 2023-10-24
IL303650B1 (en) 2024-10-01
US11338033B2 (en) 2022-05-24
JP2024123036A (ja) 2024-09-10
CA3035443A1 (en) 2018-03-08
IL265121A (cg-RX-API-DMAC7.html) 2019-04-30

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