IL299769A - Eye supplement containing glucocorticoid - Google Patents
Eye supplement containing glucocorticoidInfo
- Publication number
- IL299769A IL299769A IL299769A IL29976923A IL299769A IL 299769 A IL299769 A IL 299769A IL 299769 A IL299769 A IL 299769A IL 29976923 A IL29976923 A IL 29976923A IL 299769 A IL299769 A IL 299769A
- Authority
- IL
- Israel
- Prior art keywords
- insert
- sustained release
- release biodegradable
- biodegradable ocular
- hydrogel
- Prior art date
Links
- 239000003862 glucocorticoid Substances 0.000 title claims 16
- 238000013268 sustained release Methods 0.000 claims 41
- 239000012730 sustained-release form Substances 0.000 claims 41
- 239000000017 hydrogel Substances 0.000 claims 22
- 239000002202 Polyethylene glycol Substances 0.000 claims 15
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 15
- 229960003957 dexamethasone Drugs 0.000 claims 15
- 229920001223 polyethylene glycol Polymers 0.000 claims 15
- 239000002245 particle Substances 0.000 claims 9
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 5
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 4
- 239000002953 phosphate buffered saline Substances 0.000 claims 4
- 238000001035 drying Methods 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000001667 episodic effect Effects 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 230000000717 retained effect Effects 0.000 claims 2
- 238000007493 shaping process Methods 0.000 claims 2
- 238000012800 visualization Methods 0.000 claims 2
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 1
- 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 claims 1
- 108700021006 Interleukin-1 receptor antagonist Proteins 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- 239000008366 buffered solution Substances 0.000 claims 1
- 238000005266 casting Methods 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 229940054136 kineret Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 1
- 229920001308 poly(aminoacid) Polymers 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920001515 polyalkylene glycol Polymers 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229920005604 random copolymer Polymers 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063052646P | 2020-07-16 | 2020-07-16 | |
US202063124176P | 2020-12-11 | 2020-12-11 | |
US202163181720P | 2021-04-29 | 2021-04-29 | |
PCT/US2021/041761 WO2022015940A1 (en) | 2020-07-16 | 2021-07-15 | Ocular insert containing a glucocorticoid |
Publications (1)
Publication Number | Publication Date |
---|---|
IL299769A true IL299769A (en) | 2023-03-01 |
Family
ID=77300995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL299769A IL299769A (en) | 2020-07-16 | 2021-07-15 | Eye supplement containing glucocorticoid |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP4181930A1 (zh) |
JP (1) | JP2023534952A (zh) |
KR (1) | KR20230041708A (zh) |
CN (1) | CN116133664A (zh) |
AU (1) | AU2021309965A1 (zh) |
BR (1) | BR112023000669A2 (zh) |
CA (1) | CA3174217A1 (zh) |
IL (1) | IL299769A (zh) |
MX (1) | MX2023000628A (zh) |
WO (1) | WO2022015940A1 (zh) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008044935A (ja) | 2006-07-20 | 2008-02-28 | Sicor Inc | 固体状無菌活性医薬成分を製造する方法 |
EP2156823A1 (en) | 2008-08-14 | 2010-02-24 | Pharmatex Italia Srl | Process for the preparation of sterile powdered pharmeceutical compounds in the form of micro and nanoparticles |
US8409606B2 (en) * | 2009-02-12 | 2013-04-02 | Incept, Llc | Drug delivery through hydrogel plugs |
US11369591B2 (en) | 2015-05-12 | 2022-06-28 | Incept, Llc | Drug delivery from hydrogels |
CA3038075A1 (en) * | 2016-09-23 | 2018-03-29 | Incept, Llc | Intracameral drug delivery depots |
-
2021
- 2021-07-15 AU AU2021309965A patent/AU2021309965A1/en active Pending
- 2021-07-15 WO PCT/US2021/041761 patent/WO2022015940A1/en unknown
- 2021-07-15 IL IL299769A patent/IL299769A/en unknown
- 2021-07-15 JP JP2023502835A patent/JP2023534952A/ja active Pending
- 2021-07-15 CN CN202180060084.6A patent/CN116133664A/zh active Pending
- 2021-07-15 KR KR1020237002637A patent/KR20230041708A/ko unknown
- 2021-07-15 BR BR112023000669A patent/BR112023000669A2/pt unknown
- 2021-07-15 CA CA3174217A patent/CA3174217A1/en active Pending
- 2021-07-15 EP EP21752805.8A patent/EP4181930A1/en active Pending
- 2021-07-15 MX MX2023000628A patent/MX2023000628A/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2021309965A1 (en) | 2023-02-23 |
JP2023534952A (ja) | 2023-08-15 |
MX2023000628A (es) | 2023-02-27 |
BR112023000669A2 (pt) | 2023-04-25 |
CA3174217A1 (en) | 2022-01-20 |
KR20230041708A (ko) | 2023-03-24 |
CN116133664A (zh) | 2023-05-16 |
EP4181930A1 (en) | 2023-05-24 |
WO2022015940A1 (en) | 2022-01-20 |
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