IL299452A - מיצוי והרכב אלקלואידים פסיכואקטיביים עם דה-פוספורילציה מבוקרת - Google Patents
מיצוי והרכב אלקלואידים פסיכואקטיביים עם דה-פוספורילציה מבוקרתInfo
- Publication number
- IL299452A IL299452A IL299452A IL29945222A IL299452A IL 299452 A IL299452 A IL 299452A IL 299452 A IL299452 A IL 299452A IL 29945222 A IL29945222 A IL 29945222A IL 299452 A IL299452 A IL 299452A
- Authority
- IL
- Israel
- Prior art keywords
- psychoactive
- alkaloid
- psychoactive alkaloid
- extract
- weight
- Prior art date
Links
- 229930013930 alkaloid Natural products 0.000 title claims description 1152
- 150000003797 alkaloid derivatives Chemical class 0.000 title claims description 1041
- 239000000203 mixture Substances 0.000 title claims description 380
- 238000000605 extraction Methods 0.000 title claims description 174
- 230000030609 dephosphorylation Effects 0.000 title description 11
- 238000006209 dephosphorylation reaction Methods 0.000 title description 11
- 239000002904 solvent Substances 0.000 claims description 374
- 239000000284 extract Substances 0.000 claims description 350
- 238000000034 method Methods 0.000 claims description 157
- 239000002002 slurry Substances 0.000 claims description 152
- 230000008569 process Effects 0.000 claims description 130
- 239000002028 Biomass Substances 0.000 claims description 123
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 112
- QVDSEJDULKLHCG-UHFFFAOYSA-N Psilocybine Natural products C1=CC(OP(O)(O)=O)=C2C(CCN(C)C)=CNC2=C1 QVDSEJDULKLHCG-UHFFFAOYSA-N 0.000 claims description 104
- 229910001868 water Inorganic materials 0.000 claims description 94
- 239000007788 liquid Substances 0.000 claims description 75
- 239000002253 acid Substances 0.000 claims description 73
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 73
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- 238000001704 evaporation Methods 0.000 claims description 53
- SPCIYGNTAMCTRO-UHFFFAOYSA-N Psilocine Natural products C1=CC(O)=C2C(CCN(C)C)=CNC2=C1 SPCIYGNTAMCTRO-UHFFFAOYSA-N 0.000 claims description 46
- WTPBXXCVZZZXKR-UHFFFAOYSA-N baeocystin Chemical compound C1=CC(OP(O)(O)=O)=C2C(CCNC)=CNC2=C1 WTPBXXCVZZZXKR-UHFFFAOYSA-N 0.000 claims description 46
- ZBWSBXGHYDWMAK-UHFFFAOYSA-N psilocin Chemical compound C1=CC=C(O)[C]2C(CCN(C)C)=CN=C21 ZBWSBXGHYDWMAK-UHFFFAOYSA-N 0.000 claims description 46
- 239000007787 solid Substances 0.000 claims description 45
- IKQGYCWFBVEAKF-UHFFFAOYSA-N norbaeocystin Chemical compound C1=CC(OP(O)(O)=O)=C2C(CCN)=CNC2=C1 IKQGYCWFBVEAKF-UHFFFAOYSA-N 0.000 claims description 42
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- MTJOWJUQGYWRHT-UHFFFAOYSA-N 3-[2-(methylamino)ethyl]-1h-indol-4-ol Chemical compound C1=CC(O)=C2C(CCNC)=CNC2=C1 MTJOWJUQGYWRHT-UHFFFAOYSA-N 0.000 claims description 21
- 238000002156 mixing Methods 0.000 claims description 20
- OIIPFLWAQQNCHA-UHFFFAOYSA-N aeruginascin Chemical compound C1=CC(OP(O)([O-])=O)=C2C(CC[N+](C)(C)C)=CNC2=C1 OIIPFLWAQQNCHA-UHFFFAOYSA-N 0.000 claims description 19
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- FKIRTWDHOWAQGX-UHFFFAOYSA-N 4-hydroxytryptamine Chemical compound C1=CC(O)=C2C(CCN)=CNC2=C1 FKIRTWDHOWAQGX-UHFFFAOYSA-N 0.000 claims description 13
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- QKTAAWLCLHMUTJ-UHFFFAOYSA-N psilocybin Chemical compound C1C=CC(OP(O)(O)=O)=C2C(CCN(C)C)=CN=C21 QKTAAWLCLHMUTJ-UHFFFAOYSA-N 0.000 claims 2
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- 239000000463 material Substances 0.000 description 30
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- ZSTKHSQDNIGFLM-UHFFFAOYSA-N 5-methoxy-N,N-dimethyltryptamine Chemical compound COC1=CC=C2NC=C(CCN(C)C)C2=C1 ZSTKHSQDNIGFLM-UHFFFAOYSA-N 0.000 description 28
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- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 9
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- MSJMDZAOKORVFC-SEPHDYHBSA-L disodium fumarate Chemical compound [Na+].[Na+].[O-]C(=O)\C=C\C([O-])=O MSJMDZAOKORVFC-SEPHDYHBSA-L 0.000 description 9
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- 238000000227 grinding Methods 0.000 description 9
- 229940005740 hexametaphosphate Drugs 0.000 description 9
- QUIOHQITLKCGNW-TYYBGVCCSA-L magnesium;(e)-but-2-enedioate Chemical compound [Mg+2].[O-]C(=O)\C=C\C([O-])=O QUIOHQITLKCGNW-TYYBGVCCSA-L 0.000 description 9
- 239000001630 malic acid Substances 0.000 description 9
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- KYKNRZGSIGMXFH-ZVGUSBNCSA-M potassium bitartrate Chemical compound [K+].OC(=O)[C@H](O)[C@@H](O)C([O-])=O KYKNRZGSIGMXFH-ZVGUSBNCSA-M 0.000 description 9
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- SHPKCSFVQGSAJU-SEPHDYHBSA-L potassium fumarate Chemical compound [K+].[K+].[O-]C(=O)\C=C\C([O-])=O SHPKCSFVQGSAJU-SEPHDYHBSA-L 0.000 description 9
- 235000019295 potassium fumarate Nutrition 0.000 description 9
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CA3088384A CA3088384C (en) | 2020-06-17 | 2020-07-29 | Extraction of psychoactive compounds from psilocybin fungus |
CA3089455A CA3089455C (en) | 2020-06-17 | 2020-08-07 | Methanol-based extraction of psychoactive compounds from fungus |
CA3097246A CA3097246C (en) | 2020-10-23 | 2020-10-23 | Process for obtaining a purified psychoactive alkaloid solution |
CA3101765A CA3101765A1 (en) | 2020-12-04 | 2020-12-04 | Psychoactive alkaloid extraction and composition with controlled dephosphorylation |
CA3103707A CA3103707C (en) | 2020-12-18 | 2020-12-18 | Standardized psychoactive alkaloid extract composition |
PCT/CA2021/050813 WO2021253116A1 (en) | 2020-06-17 | 2021-06-14 | Compositions comprising psychoactive compounds from psychoactive organisms |
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IL297791A IL297791A (he) | 2020-06-17 | 2021-06-14 | תרכובות המורכבות תרכובות פסיכואקטיביות מאורגניזמים פסיכואקטיביים |
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IL297791A IL297791A (he) | 2020-06-17 | 2021-06-14 | תרכובות המורכבות תרכובות פסיכואקטיביות מאורגניזמים פסיכואקטיביים |
IL299451A IL299451A (he) | 2020-06-17 | 2021-06-14 | מיצוי אלקלואיד פסיכואקטיבי מפוספס בעיקר באמצעות אלקלי |
IL299450A IL299450A (he) | 2020-06-17 | 2021-06-14 | מיצוי מבוקרת דה-פוספורילציה של אלקלואידים פסיכואקטיביים הניתנים לזרחני |
IL299448A IL299448A (he) | 2020-06-17 | 2021-06-14 | תהליך להשגת תמיסת אלקלואיד פסיכואקטיבית מטוהרת |
IL299453A IL299453A (he) | 2020-06-17 | 2021-06-14 | מיצוי והרכב אלקלואידים פסיכואקטיביים עם דה-פוספורילציה מעוכבת |
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