IL299449A - הרכב תמצית אלקלואיד פסיכואקטיבי סטנדרטי - Google Patents
הרכב תמצית אלקלואיד פסיכואקטיבי סטנדרטיInfo
- Publication number
- IL299449A IL299449A IL299449A IL29944922A IL299449A IL 299449 A IL299449 A IL 299449A IL 299449 A IL299449 A IL 299449A IL 29944922 A IL29944922 A IL 29944922A IL 299449 A IL299449 A IL 299449A
- Authority
- IL
- Israel
- Prior art keywords
- psychoactive
- alkaloid
- weight
- composition
- extract
- Prior art date
Links
- 229930013930 alkaloid Natural products 0.000 title claims description 1069
- 150000003797 alkaloid derivatives Chemical class 0.000 title claims description 956
- 239000000203 mixture Substances 0.000 title claims description 379
- 239000000284 extract Substances 0.000 title claims description 347
- QVDSEJDULKLHCG-UHFFFAOYSA-N Psilocybine Natural products C1=CC(OP(O)(O)=O)=C2C(CCN(C)C)=CNC2=C1 QVDSEJDULKLHCG-UHFFFAOYSA-N 0.000 claims description 103
- 239000003755 preservative agent Substances 0.000 claims description 62
- 239000003795 chemical substances by application Substances 0.000 claims description 49
- SPCIYGNTAMCTRO-UHFFFAOYSA-N Psilocine Natural products C1=CC(O)=C2C(CCN(C)C)=CNC2=C1 SPCIYGNTAMCTRO-UHFFFAOYSA-N 0.000 claims description 44
- WTPBXXCVZZZXKR-UHFFFAOYSA-N baeocystin Chemical compound C1=CC(OP(O)(O)=O)=C2C(CCNC)=CNC2=C1 WTPBXXCVZZZXKR-UHFFFAOYSA-N 0.000 claims description 44
- ZBWSBXGHYDWMAK-UHFFFAOYSA-N psilocin Chemical compound C1=CC=C(O)[C]2C(CCN(C)C)=CN=C21 ZBWSBXGHYDWMAK-UHFFFAOYSA-N 0.000 claims description 44
- IKQGYCWFBVEAKF-UHFFFAOYSA-N norbaeocystin Chemical compound C1=CC(OP(O)(O)=O)=C2C(CCN)=CNC2=C1 IKQGYCWFBVEAKF-UHFFFAOYSA-N 0.000 claims description 40
- 241000233866 Fungi Species 0.000 claims description 36
- WVVSZNPYNCNODU-CJBNDPTMSA-N Ergometrine Natural products C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@@H](CO)C)C2)=C3C2=CNC3=C1 WVVSZNPYNCNODU-CJBNDPTMSA-N 0.000 claims description 33
- WVVSZNPYNCNODU-XTQGRXLLSA-N Lysergic acid propanolamide Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@H](CO)C)C2)=C3C2=CNC3=C1 WVVSZNPYNCNODU-XTQGRXLLSA-N 0.000 claims description 33
- ZSTKHSQDNIGFLM-UHFFFAOYSA-N 5-methoxy-N,N-dimethyltryptamine Chemical compound COC1=CC=C2NC=C(CCN(C)C)C2=C1 ZSTKHSQDNIGFLM-UHFFFAOYSA-N 0.000 claims description 30
- 230000002335 preservative effect Effects 0.000 claims description 29
- DMULVCHRPCFFGV-UHFFFAOYSA-N N,N-dimethyltryptamine Chemical compound C1=CC=C2C(CCN(C)C)=CNC2=C1 DMULVCHRPCFFGV-UHFFFAOYSA-N 0.000 claims description 25
- 241001062357 Psilocybe cubensis Species 0.000 claims description 25
- VTTONGPRPXSUTJ-UHFFFAOYSA-N bufotenin Chemical compound C1=C(O)C=C2C(CCN(C)C)=CNC2=C1 VTTONGPRPXSUTJ-UHFFFAOYSA-N 0.000 claims description 22
- 229960001405 ergometrine Drugs 0.000 claims description 22
- WYTJZJPVCDWOOI-KANYHAFZSA-N lysergic acid hydroxyethylamide Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@@H](O)C)C2)=C3C2=CNC3=C1 WYTJZJPVCDWOOI-KANYHAFZSA-N 0.000 claims description 22
- ZJQHPWUVQPJPQT-UHFFFAOYSA-N muscimol Chemical compound NCC1=CC(=O)NO1 ZJQHPWUVQPJPQT-UHFFFAOYSA-N 0.000 claims description 22
- 239000000126 substance Substances 0.000 claims description 21
- MTJOWJUQGYWRHT-UHFFFAOYSA-N 3-[2-(methylamino)ethyl]-1h-indol-4-ol Chemical compound C1=CC(O)=C2C(CCNC)=CNC2=C1 MTJOWJUQGYWRHT-UHFFFAOYSA-N 0.000 claims description 19
- OIIPFLWAQQNCHA-UHFFFAOYSA-N aeruginascin Chemical compound C1=CC(OP(O)([O-])=O)=C2C(CC[N+](C)(C)C)=CNC2=C1 OIIPFLWAQQNCHA-UHFFFAOYSA-N 0.000 claims description 18
- 239000000843 powder Substances 0.000 claims description 17
- IRJCBFDCFXCWGO-BYPYZUCNSA-N (2s)-2-amino-2-(3-oxo-1,2-oxazol-5-yl)acetic acid Chemical compound OC(=O)[C@@H](N)C1=CC(=O)NO1 IRJCBFDCFXCWGO-BYPYZUCNSA-N 0.000 claims description 13
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- SAHHMCVYMGARBT-HEESEWQSSA-N chanoclavine-I Chemical compound C1=CC([C@H]([C@H](NC)C2)\C=C(/C)CO)=C3C2=CNC3=C1 SAHHMCVYMGARBT-HEESEWQSSA-N 0.000 claims description 11
- DAVNRFCJMIONPO-UHFFFAOYSA-N elymoclavine Natural products C1=CC(C2C=C(CO)CN(C2C2)C)=C3C2=CNC3=C1 DAVNRFCJMIONPO-UHFFFAOYSA-N 0.000 claims description 11
- IAOSEBXZNXDPEE-UKRRQHHQSA-N elymoclavine Chemical compound C1=CC=C2[C@H]3C=C(CO)CN(C)[C@@H]3CC3=CN=C1[C]32 IAOSEBXZNXDPEE-UKRRQHHQSA-N 0.000 claims description 11
- YDPHSKXTPWQXBA-QMTHXVAHSA-N ergine Chemical compound C1=CC=C2C3=C[C@@H](C(N)=O)CN(C)[C@@H]3CC3=CN=C1[C]32 YDPHSKXTPWQXBA-QMTHXVAHSA-N 0.000 claims description 11
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- 229920002101 Chitin Polymers 0.000 claims description 6
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- 239000003963 antioxidant agent Substances 0.000 claims description 6
- 241001415382 Incilius alvarius Species 0.000 claims description 5
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- 230000003078 antioxidant effect Effects 0.000 claims description 3
- QKTAAWLCLHMUTJ-UHFFFAOYSA-N psilocybin Chemical compound C1C=CC(OP(O)(O)=O)=C2C(CCN(C)C)=CN=C21 QKTAAWLCLHMUTJ-UHFFFAOYSA-N 0.000 claims 1
- 239000002904 solvent Substances 0.000 description 372
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- 239000002028 Biomass Substances 0.000 description 115
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
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- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
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| US202063040317P | 2020-06-17 | 2020-06-17 | |
| US202063046089P | 2020-06-30 | 2020-06-30 | |
| CA3088384A CA3088384C (en) | 2020-06-17 | 2020-07-29 | Extraction of psychoactive compounds from psilocybin fungus |
| CA3089455A CA3089455C (en) | 2020-06-17 | 2020-08-07 | Methanol-based extraction of psychoactive compounds from fungus |
| CA3097246A CA3097246C (en) | 2020-10-23 | 2020-10-23 | Process for obtaining a purified psychoactive alkaloid solution |
| CA3101765A CA3101765A1 (en) | 2020-12-04 | 2020-12-04 | Psychoactive alkaloid extraction and composition with controlled dephosphorylation |
| CA3103707A CA3103707C (en) | 2020-12-18 | 2020-12-18 | Standardized psychoactive alkaloid extract composition |
| PCT/CA2021/050813 WO2021253116A1 (en) | 2020-06-17 | 2021-06-14 | Compositions comprising psychoactive compounds from psychoactive organisms |
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| IL299449A true IL299449A (he) | 2023-02-01 |
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| IL299448A IL299448A (he) | 2020-06-17 | 2021-06-14 | תהליך להשגת תמיסת אלקלואיד פסיכואקטיבית מטוהרת |
| IL299450A IL299450A (he) | 2020-06-17 | 2021-06-14 | מיצוי מבוקרת דה-פוספורילציה של אלקלואידים פסיכואקטיביים הניתנים לזרחני |
| IL305632A IL305632A (he) | 2020-06-17 | 2021-06-14 | מיצוי של תרכובות פסיכואקטיביות מפטריות פסיכדליות |
| IL298561A IL298561A (he) | 2020-06-17 | 2021-06-14 | מיצוי על בסיס מתנול של תרכובות פסיכואקטיביות מפטריה |
| IL297791A IL297791A (he) | 2020-06-17 | 2021-06-14 | תרכובות המורכבות תרכובות פסיכואקטיביות מאורגניזמים פסיכואקטיביים |
| IL299451A IL299451A (he) | 2020-06-17 | 2021-06-14 | מיצוי אלקלואיד פסיכואקטיבי מפוספס בעיקר באמצעות אלקלי |
| IL299449A IL299449A (he) | 2020-06-17 | 2021-06-14 | הרכב תמצית אלקלואיד פסיכואקטיבי סטנדרטי |
| IL299453A IL299453A (he) | 2020-06-17 | 2021-06-14 | מיצוי והרכב אלקלואידים פסיכואקטיביים עם דה-פוספורילציה מעוכבת |
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| IL299448A IL299448A (he) | 2020-06-17 | 2021-06-14 | תהליך להשגת תמיסת אלקלואיד פסיכואקטיבית מטוהרת |
| IL299450A IL299450A (he) | 2020-06-17 | 2021-06-14 | מיצוי מבוקרת דה-פוספורילציה של אלקלואידים פסיכואקטיביים הניתנים לזרחני |
| IL305632A IL305632A (he) | 2020-06-17 | 2021-06-14 | מיצוי של תרכובות פסיכואקטיביות מפטריות פסיכדליות |
| IL298561A IL298561A (he) | 2020-06-17 | 2021-06-14 | מיצוי על בסיס מתנול של תרכובות פסיכואקטיביות מפטריה |
| IL297791A IL297791A (he) | 2020-06-17 | 2021-06-14 | תרכובות המורכבות תרכובות פסיכואקטיביות מאורגניזמים פסיכואקטיביים |
| IL299451A IL299451A (he) | 2020-06-17 | 2021-06-14 | מיצוי אלקלואיד פסיכואקטיבי מפוספס בעיקר באמצעות אלקלי |
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| CA3152752A1 (en) | 2019-10-01 | 2021-04-08 | Thomas Henley | Genetic engineering of fungi to modulate tryptamine expression |
| CA3113240C (en) | 2020-12-28 | 2023-09-05 | Psilo Scientific Ltd. | Transmucosal psychoactive alkaloid composition and preparation thereof |
| WO2023225186A1 (en) * | 2022-05-18 | 2023-11-23 | Chemtor, Lp | Extraction of psilocybin and psilocin |
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| GB911946A (en) | 1958-02-21 | 1962-12-05 | Sandoz Ltd | Psilocybin and psilocin and processes for their preparation |
| LU36879A1 (he) | 1958-02-21 | |||
| DD264023A1 (de) * | 1987-07-17 | 1989-01-18 | Akad Wissenschaften Ddr | Verfahren zur extraktion von indolalkaloiden aus pilzmaterial |
| US6596298B2 (en) | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
| IL163759A0 (en) | 2002-02-28 | 2005-12-18 | Mallinckrodt Inc | Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography |
| SE0302947D0 (sv) | 2003-01-24 | 2003-11-07 | Magle Ab | A composition material for transmucosal delivery |
| EP2063861B1 (en) | 2006-09-15 | 2015-02-25 | Echo Pharmaceuticals B.V. | Dosage unit for sublingual, buccal or oral administration of water-insoluble pharmaceutically active substances |
| CN101292727A (zh) | 2008-05-30 | 2008-10-29 | 曹晋忠 | 菌类乙醇提取物的粉体制备方法 |
| NZ602572A (en) | 2010-03-30 | 2014-11-28 | Phosphagenics Ltd | Transdermal delivery patch |
| CN106573123B (zh) | 2014-06-30 | 2021-08-31 | Syqe医药有限公司 | 用于活性剂的肺部递送的方法、装置及系统 |
| US20180021326A1 (en) | 2016-07-23 | 2018-01-25 | Paul Edward Stamets | Compositions and methods for enhancing neuroregeneration and cognition by combining mushroom extracts containing active ingredients psilocin or psilocybin with erinacines or hericenones enhanced with niacin |
| NL2018190B1 (en) | 2017-01-18 | 2018-07-26 | Procare Beheer B V | Psilocybin or psilocin in combination with cannabinoid |
| US20190142851A1 (en) * | 2017-11-16 | 2019-05-16 | CaaMTech, LLC | Compositions comprising a psilocybin derivative and a cannabinoid |
| WO2018148605A1 (en) | 2017-02-09 | 2018-08-16 | CaaMTech, LLC | Compositions and methods comprising a psilocybin derivative |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| CA3132731A1 (en) | 2019-03-07 | 2020-09-10 | University Of Padova | Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic/psychotomimetic dosages and formulations |
| EP3959227A1 (en) | 2019-04-26 | 2022-03-02 | The University of North Carolina at Chapel Hill | Methods and compositions for dual glycan binding aav2.5 vector |
| CA3097246C (en) | 2020-10-23 | 2023-03-28 | Psilo Scientific Ltd. | Process for obtaining a purified psychoactive alkaloid solution |
| US20220304980A1 (en) | 2019-07-04 | 2022-09-29 | SW Holdings, Inc | Metered dosing compositions and methods of use of psychedelic compounds |
| WO2021007152A1 (en) | 2019-07-09 | 2021-01-14 | Refraction Ai, Inc. | Method and system for autonomous vehicle control |
| CA3123908C (en) | 2020-06-17 | 2022-03-22 | Psilo Scientific Ltd. | Ethanol extraction of psychoactive compounds from psilocybin fungus |
| US11382942B2 (en) | 2020-06-17 | 2022-07-12 | Psilo Scientific Ltd. | Extraction of psychoactive compounds from psilocybin fungus |
| US20220054402A1 (en) | 2020-11-05 | 2022-02-24 | Richard C Kaufman | Compositions and methods for extracting, stabilizing, and manufacturing stable dosage forms of psilocin, psychedelic drugs, entheogens, and medicinal mushrooms as nano-dimensional drug delivery structures |
| WO2022221554A2 (en) | 2021-04-16 | 2022-10-20 | Callitas Health Inc. | Compositions and methods for delivery of psilocin and prodrugs thereof |
| US20220409584A1 (en) | 2021-06-16 | 2022-12-29 | Intelgenx Corp. | Stable tryptamine oral films |
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