IL297791B2 - מיצוי של תרכובות פסיכואקטיביות מפטריות פסיכדליות - Google Patents

מיצוי של תרכובות פסיכואקטיביות מפטריות פסיכדליות

Info

Publication number
IL297791B2
IL297791B2 IL297791A IL29779122A IL297791B2 IL 297791 B2 IL297791 B2 IL 297791B2 IL 297791 A IL297791 A IL 297791A IL 29779122 A IL29779122 A IL 29779122A IL 297791 B2 IL297791 B2 IL 297791B2
Authority
IL
Israel
Prior art keywords
psychoactive
alkaloid
solvent
weight
psychoactive alkaloid
Prior art date
Application number
IL297791A
Other languages
English (en)
Other versions
IL297791A (he
IL297791B1 (he
Original Assignee
Psilo Scientific Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA3088384A external-priority patent/CA3088384C/en
Priority claimed from CA3097246A external-priority patent/CA3097246C/en
Priority claimed from CA3101765A external-priority patent/CA3101765A1/en
Priority claimed from CA3103707A external-priority patent/CA3103707C/en
Application filed by Psilo Scientific Ltd filed Critical Psilo Scientific Ltd
Priority claimed from PCT/CA2021/050813 external-priority patent/WO2021253116A1/en
Publication of IL297791A publication Critical patent/IL297791A/he
Publication of IL297791B1 publication Critical patent/IL297791B1/he
Publication of IL297791B2 publication Critical patent/IL297791B2/he

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/48Ergoline derivatives, e.g. lysergic acid, ergotamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/078Psilocybe
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/02Solvent extraction of solids
    • B01D11/0215Solid material in other stationary receptacles
    • B01D11/0253Fluidised bed of solid materials
    • B01D11/0257Fluidised bed of solid materials using mixing mechanisms, e.g. stirrers, jets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/02Solvent extraction of solids
    • B01D11/028Flow sheets
    • B01D11/0284Multistage extraction
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/02Solvent extraction of solids
    • B01D11/0288Applications, solvents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/02Solvent extraction of solids
    • B01D11/0292Treatment of the solvent
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572Five-membered rings
    • C07F9/5728Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
IL297791A 2020-06-17 2021-06-14 מיצוי של תרכובות פסיכואקטיביות מפטריות פסיכדליות IL297791B2 (he)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US202063040317P 2020-06-17 2020-06-17
US202063046089P 2020-06-30 2020-06-30
CA3088384A CA3088384C (en) 2020-06-17 2020-07-29 Extraction of psychoactive compounds from psilocybin fungus
CA3089455A CA3089455C (en) 2020-06-17 2020-08-07 Methanol-based extraction of psychoactive compounds from fungus
CA3097246A CA3097246C (en) 2020-10-23 2020-10-23 Process for obtaining a purified psychoactive alkaloid solution
CA3101765A CA3101765A1 (en) 2020-12-04 2020-12-04 Psychoactive alkaloid extraction and composition with controlled dephosphorylation
CA3103707A CA3103707C (en) 2020-12-18 2020-12-18 Standardized psychoactive alkaloid extract composition
PCT/CA2021/050813 WO2021253116A1 (en) 2020-06-17 2021-06-14 Compositions comprising psychoactive compounds from psychoactive organisms

Publications (3)

Publication Number Publication Date
IL297791A IL297791A (he) 2022-12-01
IL297791B1 IL297791B1 (he) 2025-06-01
IL297791B2 true IL297791B2 (he) 2025-10-01

Family

ID=79022851

Family Applications (9)

Application Number Title Priority Date Filing Date
IL299451A IL299451B2 (he) 2020-06-17 2021-06-14 מיצוי אלקלואיד פסיכואקטיבי מפוספס בעיקר באמצעות אלקלי
IL298561A IL298561B2 (he) 2020-06-17 2021-06-14 מיצוי על בסיס מתנול של תרכובות פסיכואקטיביות מפטריה
IL299453A IL299453B2 (he) 2020-06-17 2021-06-14 מיצוי והרכב אלקלואידים פסיכואקטיביים עם דה–פוספורילציה מעוכבת
IL299449A IL299449B2 (he) 2020-06-17 2021-06-14 הרכב תמצית אלקלואיד פסיכואקטיבי סטנדרטי
IL299450A IL299450A (he) 2020-06-17 2021-06-14 מיצוי מבוקרת דה-פוספורילציה של אלקלואידים פסיכואקטיביים הניתנים לזרחני
IL297791A IL297791B2 (he) 2020-06-17 2021-06-14 מיצוי של תרכובות פסיכואקטיביות מפטריות פסיכדליות
IL299452A IL299452B2 (he) 2020-06-17 2021-06-14 מיצוי והרכב אלקלואידים פסיכואקטיביים עם דה–פוספורילציה מבוקרת
IL305632A IL305632B2 (he) 2020-06-17 2021-06-14 מיצוי של תרכובות פסיכואקטיביות מפטריות פסיכדליות
IL299448A IL299448B2 (he) 2020-06-17 2021-06-14 תהליך להשגת תמיסת אלקלואיד פסיכואקטיבית מטוהרת

Family Applications Before (5)

Application Number Title Priority Date Filing Date
IL299451A IL299451B2 (he) 2020-06-17 2021-06-14 מיצוי אלקלואיד פסיכואקטיבי מפוספס בעיקר באמצעות אלקלי
IL298561A IL298561B2 (he) 2020-06-17 2021-06-14 מיצוי על בסיס מתנול של תרכובות פסיכואקטיביות מפטריה
IL299453A IL299453B2 (he) 2020-06-17 2021-06-14 מיצוי והרכב אלקלואידים פסיכואקטיביים עם דה–פוספורילציה מעוכבת
IL299449A IL299449B2 (he) 2020-06-17 2021-06-14 הרכב תמצית אלקלואיד פסיכואקטיבי סטנדרטי
IL299450A IL299450A (he) 2020-06-17 2021-06-14 מיצוי מבוקרת דה-פוספורילציה של אלקלואידים פסיכואקטיביים הניתנים לזרחני

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL299452A IL299452B2 (he) 2020-06-17 2021-06-14 מיצוי והרכב אלקלואידים פסיכואקטיביים עם דה–פוספורילציה מבוקרת
IL305632A IL305632B2 (he) 2020-06-17 2021-06-14 מיצוי של תרכובות פסיכואקטיביות מפטריות פסיכדליות
IL299448A IL299448B2 (he) 2020-06-17 2021-06-14 תהליך להשגת תמיסת אלקלואיד פסיכואקטיבית מטוהרת

Country Status (6)

Country Link
US (4) US11331357B2 (he)
EP (1) EP4161546A4 (he)
AU (7) AU2021290454B2 (he)
BR (1) BR112022025780A2 (he)
IL (9) IL299451B2 (he)
MX (1) MX2022016533A (he)

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WO2021067626A2 (en) 2019-10-01 2021-04-08 Intima Bioscience, Inc. Genetic engineering of fungi to modulate tryptamine expression
CA3197443C (en) 2020-12-28 2024-10-22 Psilo Scientific Ltd. METHODS FOR EXTRACTION OF PSYCHOACTIVE ALKALOIDS AND RELATED PREPARATION IN TRANSMUCOSAL FORMS
US20220370413A1 (en) 2021-03-06 2022-11-24 Mind Medicine, Inc. Formulations of psilocin that have enhanced stability
CA3127180C (en) * 2021-08-06 2024-03-05 Psilo Scientific Ltd. Pre-evaporation standardization of extracted psychoactive compounds
AU2022356260A1 (en) * 2021-09-28 2024-04-11 Joseph Girardi Chilled juice extraction processes and products using psychedelic and functional mushrooms
CA3133547C (en) * 2021-10-07 2024-07-02 Psilo Scientific Ltd. LIQUID-LIQUID EXTRACTION OF PURIFIED PSYCHOACTIVE ALKALOIDS
EP4457336A4 (en) 2021-12-31 2026-01-14 Empyrean Neuroscience Inc ORGANISMS GENETICALLY MODIFIED TO PRODUCE PSYCHOTROPIC ALKALOIDS
WO2023225186A1 (en) * 2022-05-18 2023-11-23 Chemtor, Lp Extraction of psilocybin and psilocin
GB202313750D0 (en) 2023-09-08 2023-10-25 Psyence Group Inc A process for obtaining a purified psychoactive alkaloid
WO2025087962A1 (en) 2023-10-23 2025-05-01 Reconnect Labs Ag Pharmaceutical formulations comprising 5-meo-dmt and their therapeutic uses

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