IL299223A - Use of trans-[tetrachlorobis(1h-indazole)ruthenate (iii)] for the treatment of cancer - Google Patents
Use of trans-[tetrachlorobis(1h-indazole)ruthenate (iii)] for the treatment of cancerInfo
- Publication number
- IL299223A IL299223A IL299223A IL29922322A IL299223A IL 299223 A IL299223 A IL 299223A IL 299223 A IL299223 A IL 299223A IL 29922322 A IL29922322 A IL 29922322A IL 299223 A IL299223 A IL 299223A
- Authority
- IL
- Israel
- Prior art keywords
- administered
- patient
- pharmaceutically acceptable
- use according
- acceptable composition
- Prior art date
Links
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61P35/00—Antineoplastic agents
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US201662301786P | 2016-03-01 | 2016-03-01 | |
| PCT/US2017/020209 WO2017151775A1 (en) | 2016-03-01 | 2017-03-01 | Use of trans-[tetrachlorobis(1h-indazole)ruthenate (iii)] for the treatment of cancer |
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| IL299223A true IL299223A (en) | 2023-02-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| IL299223A IL299223A (en) | 2016-03-01 | 2017-03-01 | Use of trans-[tetrachlorobis(1h-indazole)ruthenate (iii)] for the treatment of cancer |
| IL261384A IL261384B2 (en) | 2016-03-01 | 2018-08-26 | Use of trans-[tetrachlorobis(h1-indazole)rotenate(iii)] for cancer treatment |
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| Application Number | Title | Priority Date | Filing Date |
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| IL261384A IL261384B2 (en) | 2016-03-01 | 2018-08-26 | Use of trans-[tetrachlorobis(h1-indazole)rotenate(iii)] for cancer treatment |
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| AU (1) | AU2017227705A1 (enExample) |
| IL (2) | IL299223A (enExample) |
| WO (2) | WO2017151775A1 (enExample) |
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| KR20220075450A (ko) * | 2016-03-01 | 2022-06-08 | 인터자인 테크놀로지스, 인코포레이티드 | 암 치료용 트랜스-[테트라클로로비스(1h-인다졸)루테네이트(iii)]의 용도 |
| WO2018134254A1 (en) | 2017-01-17 | 2018-07-26 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| US20230024119A1 (en) * | 2019-12-05 | 2023-01-26 | Bold Therapeutics, Inc. | Combined use of sodium trans-[tetrachloridobis(1h-indazole)ruthenate(iii)] and etomoxir for treating cancers |
| US11730750B2 (en) | 2020-02-17 | 2023-08-22 | University Of Kentucky Research Foundation | Drugs for GRP78 cell surface translocation and Par-4 secretion |
| WO2021195763A1 (en) * | 2020-03-30 | 2021-10-07 | Bold Therapeutics Inc. | Antiviral ruthenate(iii) therapeutics |
| US20250235465A1 (en) * | 2021-10-28 | 2025-07-24 | Bold Therapeutics Inc. | Use of sodium trans-[tetrachloridobis(1h-indazole)ruthenate(iii)] to ameliorate proteasome inhibitor resistance |
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| PT2152084E (pt) | 2007-06-11 | 2014-01-23 | Niiki Pharma Inc | Método de fabrico de um complexo de ruténio |
| JP6034288B2 (ja) | 2010-07-18 | 2016-11-30 | ニーキ ファーマ インコーポレイテッド | ルテニウム錯体を用いる併用療法 |
| JP6116481B2 (ja) * | 2010-10-25 | 2017-04-19 | ニーキ ファーマ インコーポレイテッド | 神経内分泌腫瘍を治療する方法 |
| WO2016029073A2 (en) | 2014-08-22 | 2016-02-25 | Bristol-Myers Squibb Company | Treatment of cancer using a combination of an anti-pd-1 antibody and an anti-cd137 antibody |
| KR20220075450A (ko) * | 2016-03-01 | 2022-06-08 | 인터자인 테크놀로지스, 인코포레이티드 | 암 치료용 트랜스-[테트라클로로비스(1h-인다졸)루테네이트(iii)]의 용도 |
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2017
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2018
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| AU2017227705A9 (en) | 2018-12-20 |
| WO2017151775A9 (en) | 2018-09-13 |
| KR102413412B1 (ko) | 2022-06-28 |
| CN109195600A (zh) | 2019-01-11 |
| KR20220075450A (ko) | 2022-06-08 |
| JP2021167360A (ja) | 2021-10-21 |
| EP3423055A4 (en) | 2019-10-16 |
| US20210085647A1 (en) | 2021-03-25 |
| US10821095B2 (en) | 2020-11-03 |
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| IL261384A (en) | 2018-10-31 |
| EP3423055A1 (en) | 2019-01-09 |
| IL261384B2 (en) | 2023-05-01 |
| JP6997919B2 (ja) | 2022-01-18 |
| IL261384B1 (en) | 2023-01-01 |
| WO2017151762A1 (en) | 2017-09-08 |
| AU2017227705A1 (en) | 2018-10-18 |
| US20240091196A1 (en) | 2024-03-21 |
| US20190038601A1 (en) | 2019-02-07 |
| KR20180130509A (ko) | 2018-12-07 |
| JP2023024618A (ja) | 2023-02-16 |
| US11633380B2 (en) | 2023-04-25 |
| JP7513574B2 (ja) | 2024-07-09 |
| WO2017151775A1 (en) | 2017-09-08 |
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