CN109195600A - 反式-[四氯双(1h-吲唑)钌(iii)酸盐]用于治疗癌症的用途 - Google Patents

反式-[四氯双(1h-吲唑)钌(iii)酸盐]用于治疗癌症的用途 Download PDF

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Publication number
CN109195600A
CN109195600A CN201780027237.0A CN201780027237A CN109195600A CN 109195600 A CN109195600 A CN 109195600A CN 201780027237 A CN201780027237 A CN 201780027237A CN 109195600 A CN109195600 A CN 109195600A
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Prior art keywords
cancer
patient
grp78
pharmaceutically acceptable
cell
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Pending
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CN201780027237.0A
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English (en)
Chinese (zh)
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S·贝克维尔
J·塞图拉曼
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Intezyne Technologies Inc
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Intezyne Technologies Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
CN201780027237.0A 2016-03-01 2017-03-01 反式-[四氯双(1h-吲唑)钌(iii)酸盐]用于治疗癌症的用途 Pending CN109195600A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662301786P 2016-03-01 2016-03-01
US62/301,786 2016-03-01
PCT/US2017/020209 WO2017151775A1 (en) 2016-03-01 2017-03-01 Use of trans-[tetrachlorobis(1h-indazole)ruthenate (iii)] for the treatment of cancer

Publications (1)

Publication Number Publication Date
CN109195600A true CN109195600A (zh) 2019-01-11

Family

ID=59744351

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780027237.0A Pending CN109195600A (zh) 2016-03-01 2017-03-01 反式-[四氯双(1h-吲唑)钌(iii)酸盐]用于治疗癌症的用途

Country Status (8)

Country Link
US (3) US10821095B2 (enExample)
EP (1) EP3423055A4 (enExample)
JP (3) JP6997919B2 (enExample)
KR (2) KR20220075450A (enExample)
CN (1) CN109195600A (enExample)
AU (1) AU2017227705A1 (enExample)
IL (2) IL299223A (enExample)
WO (2) WO2017151775A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL299223A (en) * 2016-03-01 2023-02-01 Intezyne Tech Use of trans-[tetrachlorobis(1h-indazole)ruthenate (iii)] for the treatment of cancer
US11040027B2 (en) 2017-01-17 2021-06-22 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
US20230024119A1 (en) * 2019-12-05 2023-01-26 Bold Therapeutics, Inc. Combined use of sodium trans-[tetrachloridobis(1h-indazole)ruthenate(iii)] and etomoxir for treating cancers
US11730750B2 (en) 2020-02-17 2023-08-22 University Of Kentucky Research Foundation Drugs for GRP78 cell surface translocation and Par-4 secretion
WO2021195763A1 (en) * 2020-03-30 2021-10-07 Bold Therapeutics Inc. Antiviral ruthenate(iii) therapeutics
KR20240091105A (ko) * 2021-10-28 2024-06-21 볼드 테라퓨틱스 인코포레이티드 프로테아좀 억제제 내성을 개선시키기 위한 나트륨 트랜스-[테트라클로리도비스(1h-인다졸)루테네이트(iii)]의 용도

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130129840A1 (en) * 2010-07-18 2013-05-23 Niiki Pharma Inc. Combination therapy using a ruthenium complex

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5296063B2 (ja) 2007-06-11 2013-09-25 ニッキ ファーマ インク． ルテニウム錯体を製造する方法
WO2012061086A2 (en) * 2010-10-25 2012-05-10 Niiki Pharma Inc. Method of treating neuroendocrine tumors
EP3183269A2 (en) 2014-08-22 2017-06-28 Bristol-Myers Squibb Company Treatment of cancer using a combination of an anti-pd-1 antibody and an anti-cd137 antibody
IL299223A (en) * 2016-03-01 2023-02-01 Intezyne Tech Use of trans-[tetrachlorobis(1h-indazole)ruthenate (iii)] for the treatment of cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130129840A1 (en) * 2010-07-18 2013-05-23 Niiki Pharma Inc. Combination therapy using a ruthenium complex

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. B. GIFFORD ET AL: ""Expression of GRP78, Master Regulator of the Unfolded protein Response, Increases Chemoresistance in Pancreatic Ductal Adenocarcinoma"", 《MOLECULAR CANCER THERAPEUTICS》 *
PATRA HEFFETER ET AL: ""The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo"", 《EUROPEAN JOURNAL OF CANCER》 *

Also Published As

Publication number Publication date
WO2017151775A9 (en) 2018-09-13
JP2023024618A (ja) 2023-02-16
WO2017151762A1 (en) 2017-09-08
JP2019507166A (ja) 2019-03-14
JP7513574B2 (ja) 2024-07-09
KR20220075450A (ko) 2022-06-08
EP3423055A1 (en) 2019-01-09
WO2017151775A1 (en) 2017-09-08
JP2021167360A (ja) 2021-10-21
IL261384B1 (en) 2023-01-01
KR102413412B1 (ko) 2022-06-28
IL261384B2 (en) 2023-05-01
IL299223A (en) 2023-02-01
EP3423055A4 (en) 2019-10-16
US20240091196A1 (en) 2024-03-21
US20210085647A1 (en) 2021-03-25
JP6997919B2 (ja) 2022-01-18
IL261384A (en) 2018-10-31
US10821095B2 (en) 2020-11-03
AU2017227705A1 (en) 2018-10-18
US11633380B2 (en) 2023-04-25
US20190038601A1 (en) 2019-02-07
AU2017227705A9 (en) 2018-12-20
KR20180130509A (ko) 2018-12-07

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