IL295785A - An optically degradable trolox intermediate and a method for its production - Google Patents
An optically degradable trolox intermediate and a method for its productionInfo
- Publication number
- IL295785A IL295785A IL295785A IL29578522A IL295785A IL 295785 A IL295785 A IL 295785A IL 295785 A IL295785 A IL 295785A IL 29578522 A IL29578522 A IL 29578522A IL 295785 A IL295785 A IL 295785A
- Authority
- IL
- Israel
- Prior art keywords
- amide
- formula
- compound
- based solvent
- trolox
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020028614 | 2020-02-21 | ||
| PCT/JP2021/006465 WO2021167095A1 (ja) | 2020-02-21 | 2021-02-19 | 光学分割されたトロロックス中間体およびその製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL295785A true IL295785A (en) | 2022-10-01 |
Family
ID=77390820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL295785A IL295785A (en) | 2020-02-21 | 2021-02-19 | An optically degradable trolox intermediate and a method for its production |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12509434B2 (https=) |
| EP (1) | EP4108658A4 (https=) |
| JP (2) | JP7840259B2 (https=) |
| KR (1) | KR20220143897A (https=) |
| CN (1) | CN115066420B (https=) |
| BR (1) | BR112022016508A2 (https=) |
| IL (1) | IL295785A (https=) |
| WO (1) | WO2021167095A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20250133A (es) | 2022-09-12 | 2025-06-26 | Ptc Therapeutics Inc | Granulos para suspension |
| AU2023352262A1 (en) | 2022-09-30 | 2025-04-24 | Ptc Therapeutics, Inc. | Oxidative cleavage method of trolox amide |
| WO2025117870A1 (en) | 2023-12-01 | 2025-06-05 | Ptc Therapeutics, Inc. | Method of electrolytic oxidative cleavage of trolox amide |
| WO2025193975A1 (en) | 2024-03-13 | 2025-09-18 | Ptc Therapeutics, Inc. | Formulations for stabilizing dissolution of medicaments |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA739471B (en) * | 1972-12-22 | 1974-08-28 | Hoffmann La Roche | Chromane derivatives |
| US3947473A (en) | 1972-12-22 | 1976-03-30 | Hoffman-La Roche Inc. | Antioxidant chroman compounds |
| US4003919A (en) | 1973-11-19 | 1977-01-18 | Hoffmann-La Roche Inc. | Antioxidant chroman compounds |
| US4026907A (en) | 1973-11-19 | 1977-05-31 | Hoffmann-La Roche Inc. | Antioxidant chroman compounds |
| WO2002012221A1 (en) * | 2000-08-03 | 2002-02-14 | Kuraray Co., Ltd. | Method for optical resolution of (±)-6-hydroxy-2,5,7,8-tetramethylcoumarone-2-carboxylic acid |
| JP2002167381A (ja) * | 2000-08-03 | 2002-06-11 | Kuraray Co Ltd | （±）−６−ヒドロキシ−２，５，７，８−テトラメチルクロマン−２−カルボン酸の光学分割法 |
| EA038941B1 (ru) | 2007-11-06 | 2021-11-12 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ |
| JP5598330B2 (ja) * | 2008-10-29 | 2014-10-01 | 三菱瓦斯化学株式会社 | 光学活性有機カルボン酸の製造方法 |
| KR20110086723A (ko) | 2008-11-07 | 2011-07-29 | 시플라 리미티드 | 조피클론을 광학분할하는 방법 |
| JP5641802B2 (ja) * | 2010-07-26 | 2014-12-17 | 株式会社トクヤマ | （ｓ）−４−〔（４−クロロフェニル）（２−ピリジル）メトキシ〕ピペリジンのジアステレオマー塩の製造方法 |
| JPWO2013011999A1 (ja) * | 2011-07-20 | 2015-02-23 | 株式会社カネカ | 光学活性２−メチルプロリン誘導体の製造法 |
| CN105164105B (zh) | 2013-04-10 | 2018-01-30 | 第一三共株式会社 | 吡咯衍生物的结晶及其制备方法 |
| DK3233786T3 (da) * | 2014-12-16 | 2022-05-09 | Ptc Therapeutics Inc | Polymorfe og amorfe former af (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6- dioxocyclohexa-1,4-dienyl)butanamid |
| EP3233819A1 (en) * | 2014-12-16 | 2017-10-25 | Bioelectron Technology Corporation | Methods for chiral resolution of trolox |
| JP2020028614A (ja) | 2018-08-24 | 2020-02-27 | 株式会社三共 | 遊技機 |
-
2021
- 2021-02-19 EP EP21757166.0A patent/EP4108658A4/en active Pending
- 2021-02-19 IL IL295785A patent/IL295785A/en unknown
- 2021-02-19 WO PCT/JP2021/006465 patent/WO2021167095A1/ja not_active Ceased
- 2021-02-19 JP JP2022501092A patent/JP7840259B2/ja active Active
- 2021-02-19 US US17/801,237 patent/US12509434B2/en active Active
- 2021-02-19 CN CN202180015723.7A patent/CN115066420B/zh active Active
- 2021-02-19 BR BR112022016508A patent/BR112022016508A2/pt unknown
- 2021-02-19 KR KR1020227032224A patent/KR20220143897A/ko active Pending
-
2025
- 2025-12-04 JP JP2025232373A patent/JP2026041900A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US12509434B2 (en) | 2025-12-30 |
| JPWO2021167095A1 (https=) | 2021-08-26 |
| JP2026041900A (ja) | 2026-03-10 |
| EP4108658A4 (en) | 2024-05-22 |
| JP7840259B2 (ja) | 2026-04-03 |
| WO2021167095A1 (ja) | 2021-08-26 |
| CN115066420A (zh) | 2022-09-16 |
| EP4108658A1 (en) | 2022-12-28 |
| CN115066420B (zh) | 2024-12-10 |
| KR20220143897A (ko) | 2022-10-25 |
| US20230029044A1 (en) | 2023-01-26 |
| BR112022016508A2 (pt) | 2022-10-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL295785A (en) | An optically degradable trolox intermediate and a method for its production | |
| IL225808A (en) | Sesquihydrate of 1-{(2s)-2-amino-4-[2,4-bis(trifluoromethyl)-5,8-di-hydropyrido[3,4-d]pyrimidin-7(6h)-yl]-4-oxobutyl}-5,5-difluoro-piperidin-2-one tartrate, process for its preparation and pharmaceutical compositions comprising it for treating diabetes and obesity | |
| IL292005B1 (en) | Solid-state crystalline forms of N-[4-(6-fluoro-3,4-dihydro-H1-isoquinolin-2-yl)-2,6-dimethylphenyl]-3,3-dimethylbutanamide | |
| IL298753A (en) | A pentavalent heteroaromatic imidazole compound and its use | |
| IL310699B1 (en) | Thr-beta receptor agonist compound and preparation method and use thereof | |
| IL268683B (en) | Processes for preparing ag-10, its intermediates, and salts thereof | |
| NZ555538A (en) | Method for preparation of organofluoro compounds in alcohol solvents | |
| IL278281B2 (en) | Crystalline form of C–MET inhibitor and its salt form and method for preparing them | |
| IL296447A (en) | Preparation of an mcl-1 inhibitory compound using methylation in the presence of water | |
| IL292210B2 (en) | An efficient process for the synthesis of 2-amino-5-chloro-n,3-dimethylbenzamide | |
| IL302651A (en) | Integrin inhibitors and their uses | |
| NZ585794A (en) | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids | |
| IL279853B2 (en) | Polymorphic forms of RAD 1901-2HCL | |
| IL237724A (en) | Stable 595-sns vaccines and methods for preparing them | |
| IL303028A (en) | Methods for the synthesis of substituted pyridinone-pyridinyl compounds | |
| IL322463A (en) | Deuterated d-serine analogs and their uses | |
| IL297458A (en) | Boronic acid derivatives and their synthesis, polymorphic forms and medicinal uses | |
| IL301052A (en) | A triazine compound salt, its crystal form, and its production method | |
| IL319273A (en) | A series of bridged nitrogen-containing heterocyclic compounds and a method for their preparation | |
| IL259418B2 (en) | Triarylmethane compound, a dye compound for staining the ocular membrane | |
| CN121293147A (zh) | S-吲哚洛尔的有机酸加成盐 | |
| IL284564B2 (en) | Polymorphic forms of a substituted-quinoxaline-type bridged-piperidine compound | |
| IL275153B1 (en) | Fumarate salt of (r)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2-trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl) urea, methods of preparation, and uses thereof | |
| IL322762A (en) | Crystalline form of pyrrolopyridine derivative | |
| IL302652A (en) | Process for preparation of 2-hydroxy-6-((2-(1-isopropyl- 1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |