IL295288B2 - Anti-complement factor BB antibodies and their uses - Google Patents

Anti-complement factor BB antibodies and their uses

Info

Publication number
IL295288B2
IL295288B2 IL295288A IL29528822A IL295288B2 IL 295288 B2 IL295288 B2 IL 295288B2 IL 295288 A IL295288 A IL 295288A IL 29528822 A IL29528822 A IL 29528822A IL 295288 B2 IL295288 B2 IL 295288B2
Authority
IL
Israel
Prior art keywords
antibody
seq
amino acid
region
acid sequence
Prior art date
Application number
IL295288A
Other languages
English (en)
Hebrew (he)
Other versions
IL295288A (en
IL295288B1 (en
Original Assignee
Bioverativ Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioverativ Usa Inc filed Critical Bioverativ Usa Inc
Publication of IL295288A publication Critical patent/IL295288A/en
Publication of IL295288B1 publication Critical patent/IL295288B1/en
Publication of IL295288B2 publication Critical patent/IL295288B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL295288A 2016-04-04 2017-04-03 Anti-complement factor BB antibodies and their uses IL295288B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662317897P 2016-04-04 2016-04-04
PCT/US2017/025784 WO2017176651A1 (en) 2016-04-04 2017-04-03 Anti-complement factor bb antibodies and uses thereof

Publications (3)

Publication Number Publication Date
IL295288A IL295288A (en) 2022-10-01
IL295288B1 IL295288B1 (en) 2024-04-01
IL295288B2 true IL295288B2 (en) 2024-08-01

Family

ID=60000646

Family Applications (3)

Application Number Title Priority Date Filing Date
IL295288A IL295288B2 (en) 2016-04-04 2017-04-03 Anti-complement factor BB antibodies and their uses
IL262010A IL262010B (en) 2016-04-04 2017-04-03 Anti-complement factor bb antibodies and their uses
IL311675A IL311675A (en) 2016-04-04 2017-04-03 Anti-complement factor BB antibodies and their uses

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL262010A IL262010B (en) 2016-04-04 2017-04-03 Anti-complement factor bb antibodies and their uses
IL311675A IL311675A (en) 2016-04-04 2017-04-03 Anti-complement factor BB antibodies and their uses

Country Status (23)

Country Link
US (3) US10934347B2 (OSRAM)
EP (1) EP3452510A4 (OSRAM)
JP (3) JP6967528B2 (OSRAM)
KR (2) KR102673420B1 (OSRAM)
CN (2) CN109563158B (OSRAM)
AU (2) AU2017246794B2 (OSRAM)
BR (1) BR112018070357A2 (OSRAM)
CA (1) CA3019332A1 (OSRAM)
CL (1) CL2018002810A1 (OSRAM)
CO (1) CO2018010827A2 (OSRAM)
CR (1) CR20180529A (OSRAM)
DO (1) DOP2018000219A (OSRAM)
EA (1) EA201892225A1 (OSRAM)
EC (1) ECSP18082302A (OSRAM)
IL (3) IL295288B2 (OSRAM)
MA (1) MA44878A (OSRAM)
MX (2) MX2018012176A (OSRAM)
MY (1) MY194603A (OSRAM)
PE (1) PE20190209A1 (OSRAM)
PH (1) PH12018502137A1 (OSRAM)
SG (1) SG11201808525UA (OSRAM)
TN (1) TN2018000341A1 (OSRAM)
WO (1) WO2017176651A1 (OSRAM)

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KR102066996B1 (ko) 2010-07-28 2020-01-17 글리크닉 인코포레이티드 순차적으로 다중화된 면역글로불린 fc 조성물을 제조하기 위한 천연 인간 단백질 단편들의 융합 단백질
MX394116B (es) 2015-07-24 2025-03-19 Gliknik Inc Proteinas de fusion de fragmentos de proteina humana para crear composiciones de fc de inmunoglobulina multimerizada de forma ordenada con union al complemento aumentada.
TN2018000341A1 (en) 2016-04-04 2020-06-15 Bioverativ Usa Inc ANTl-COMPLEMENT FACTOR BB ANTIBODIES AND USES THEREOF.
IL317014A (en) 2016-12-09 2025-01-01 Gliknik Inc Production optimization of GL-2045, a multimerization sterol.
CN110022898B (zh) 2016-12-09 2023-07-04 格利克尼克股份有限公司 用多价Fc化合物治疗炎性疾病的方法
JP2020518240A (ja) * 2017-01-17 2020-06-25 ザ テキサス エー アンド エム ユニバーシティー システム 標的細胞のエンドリソソーム区画へのカーゴ分子の送達の向上のためのエンドリソソーム標的化コンジュゲート
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CA3085945A1 (en) 2017-12-19 2019-06-27 The University Of North Carolina At Chapel Hill Methods and compositions for delivery of viral vectors across the blood-brain barrier
CN114728057A (zh) * 2019-06-27 2022-07-08 维西欧制药公司 用于调节髓系细胞炎性表型的抗cd53组合物和方法及其用途
BR112022000739A2 (pt) * 2019-07-17 2022-04-12 Gemini Therapeutics Sub Inc Anticorpos de potencialização de fator h e usos dos mesmos
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MX2022013135A (es) * 2020-04-20 2022-11-10 Genzyme Corp Anticuerpos anti-factor bb del complemento humanizados y usos de los mismos.
JP7787164B2 (ja) 2020-09-23 2025-12-16 アキリオン ファーマシューティカルズ， インコーポレーテッド 補体媒介性障害の治療のための医薬化合物

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Also Published As

Publication number Publication date
DOP2018000219A (es) 2019-03-31
EP3452510A4 (en) 2020-01-15
MY194603A (en) 2022-12-06
CN116790614A (zh) 2023-09-22
NZ747018A (en) 2025-05-02
BR112018070357A2 (pt) 2019-01-29
IL262010B (en) 2022-09-01
AU2024224000A1 (en) 2024-12-19
IL311675A (en) 2024-05-01
WO2017176651A1 (en) 2017-10-12
CO2018010827A2 (es) 2018-11-22
TN2018000341A1 (en) 2020-06-15
CN109563158B (zh) 2022-08-09
CA3019332A1 (en) 2017-10-12
EA201892225A1 (ru) 2019-09-30
CR20180529A (es) 2019-03-21
KR20240096672A (ko) 2024-06-26
US20190153079A1 (en) 2019-05-23
AU2017246794A1 (en) 2018-10-25
US11851482B2 (en) 2023-12-26
US10934347B2 (en) 2021-03-02
SG11201808525UA (en) 2018-10-30
JP2019513726A (ja) 2019-05-30
IL295288A (en) 2022-10-01
KR20190003951A (ko) 2019-01-10
MA44878A (fr) 2019-03-13
US20240228599A1 (en) 2024-07-11
IL295288B1 (en) 2024-04-01
EP3452510A1 (en) 2019-03-13
JP7326393B2 (ja) 2023-08-15
PH12018502137A1 (en) 2019-09-23
IL262010A (en) 2018-10-31
CN109563158A (zh) 2019-04-02
JP2023139289A (ja) 2023-10-03
KR102673420B1 (ko) 2024-06-07
US20210221877A1 (en) 2021-07-22
JP6967528B2 (ja) 2021-11-17
CL2018002810A1 (es) 2019-03-15
MX2018012176A (es) 2019-02-07
PE20190209A1 (es) 2019-02-07
AU2017246794B2 (en) 2024-07-04
MX2023007149A (es) 2023-06-28
JP2021191789A (ja) 2021-12-16
ECSP18082302A (es) 2019-01-31

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