IL294775A - Recombinant aav production - Google Patents
Recombinant aav productionInfo
- Publication number
- IL294775A IL294775A IL294775A IL29477522A IL294775A IL 294775 A IL294775 A IL 294775A IL 294775 A IL294775 A IL 294775A IL 29477522 A IL29477522 A IL 29477522A IL 294775 A IL294775 A IL 294775A
- Authority
- IL
- Israel
- Prior art keywords
- aav
- nucleic acid
- raav
- cell line
- dna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062962911P | 2020-01-17 | 2020-01-17 | |
| PCT/US2021/013689 WO2021146591A2 (en) | 2020-01-17 | 2021-01-15 | Recombinant aav production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL294775A true IL294775A (en) | 2022-09-01 |
Family
ID=76864730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL294775A IL294775A (en) | 2020-01-17 | 2021-01-15 | Recombinant aav production |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230048994A1 (https=) |
| EP (1) | EP4090750A4 (https=) |
| JP (2) | JP7846625B2 (https=) |
| CN (1) | CN115315518A (https=) |
| AU (1) | AU2021207683A1 (https=) |
| CA (1) | CA3162520A1 (https=) |
| IL (1) | IL294775A (https=) |
| WO (1) | WO2021146591A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4189077A1 (en) | 2020-07-30 | 2023-06-07 | Shape Therapeutics Inc. | Stable cell lines for inducible production of raav virions |
| AU2022373653A1 (en) | 2021-10-18 | 2024-05-02 | Regeneron Pharmaceuticals, Inc. | Eukaryotic cells comprising adenovirus-associated virus polynucleotides |
| WO2024129882A1 (en) * | 2022-12-14 | 2024-06-20 | Astellas Gene Therapies, Inc. | Compositions and methods for improved production of adeno-associated viral particles |
| AU2024223271A1 (en) * | 2023-02-17 | 2025-09-18 | Synplogen Co., Ltd. | Itr-rep gene complex |
| EP4527938A1 (en) * | 2023-09-22 | 2025-03-26 | LenioBio GmbH | Method for cell-free polypeptide synthesis |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6995006B2 (en) * | 1997-09-05 | 2006-02-07 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| EP2848253A1 (en) * | 2006-06-19 | 2015-03-18 | Asklepios Biopharmaceutical, Inc. | Modified factor VIII and factor IX genes and vectors for gene therapy |
| WO2008105931A2 (en) * | 2006-09-15 | 2008-09-04 | Medimmune Vaccines, Inc. | Mdck cell lines supporting viral growth to high titers and bioreactor process using the same |
| GB0901593D0 (en) * | 2009-01-30 | 2009-03-11 | Touchlight Genetics Ltd | Production of closed linear DNA |
| US9441206B2 (en) * | 2011-10-28 | 2016-09-13 | The University Of North Carolina At Chapel Hill | Cell line for production of adeno-associated virus |
| EP3039129B1 (en) * | 2013-08-30 | 2018-06-27 | Amgen Inc. | High titer recombinant aav vector production in adherent and suspension cells |
| AU2016362317B2 (en) * | 2015-12-01 | 2023-03-16 | Spark Therapeutics, Inc. | Scalable methods for producing recombinant Adeno-Associated Viral (AAV) vector in serum-free suspension cell culture system suitable for clinical use |
| EP3810782A2 (en) * | 2018-06-22 | 2021-04-28 | Asklepios Biopharmaceutical, Inc. | Vectors for gene delivery that persist within cells |
-
2021
- 2021-01-15 WO PCT/US2021/013689 patent/WO2021146591A2/en not_active Ceased
- 2021-01-15 AU AU2021207683A patent/AU2021207683A1/en active Pending
- 2021-01-15 CA CA3162520A patent/CA3162520A1/en active Pending
- 2021-01-15 CN CN202180023263.2A patent/CN115315518A/zh active Pending
- 2021-01-15 EP EP21741128.9A patent/EP4090750A4/en active Pending
- 2021-01-15 US US17/793,196 patent/US20230048994A1/en active Pending
- 2021-01-15 JP JP2022543381A patent/JP7846625B2/ja active Active
- 2021-01-15 IL IL294775A patent/IL294775A/en unknown
-
2025
- 2025-11-14 JP JP2025195186A patent/JP2026032042A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021146591A3 (en) | 2021-10-28 |
| CN115315518A (zh) | 2022-11-08 |
| JP2026032042A (ja) | 2026-02-25 |
| JP2023510590A (ja) | 2023-03-14 |
| EP4090750A4 (en) | 2024-03-13 |
| AU2021207683A1 (en) | 2022-08-11 |
| US20230048994A1 (en) | 2023-02-16 |
| CA3162520A1 (en) | 2021-07-22 |
| JP7846625B2 (ja) | 2026-04-15 |
| EP4090750A2 (en) | 2022-11-23 |
| WO2021146591A2 (en) | 2021-07-22 |
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