IL294655A - נוגדנים אנטי-2trem ושיטות לשימוש בהם - Google Patents
נוגדנים אנטי-2trem ושיטות לשימוש בהםInfo
- Publication number
- IL294655A IL294655A IL294655A IL29465522A IL294655A IL 294655 A IL294655 A IL 294655A IL 294655 A IL294655 A IL 294655A IL 29465522 A IL29465522 A IL 29465522A IL 294655 A IL294655 A IL 294655A
- Authority
- IL
- Israel
- Prior art keywords
- seq
- antibody
- amino acid
- acid sequence
- sequence
- Prior art date
Links
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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US202063091717P | 2020-10-14 | 2020-10-14 | |
PCT/US2021/013200 WO2021146256A1 (en) | 2020-01-13 | 2021-01-13 | Anti-trem2 antibodies and methods of use thereof |
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IL294655A IL294655A (he) | 2020-01-13 | 2021-01-13 | נוגדנים אנטי-2trem ושיטות לשימוש בהם |
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US (2) | US11124567B2 (he) |
EP (1) | EP4090682A1 (he) |
JP (1) | JP2023512450A (he) |
KR (1) | KR20220131246A (he) |
CN (1) | CN115279790A (he) |
AU (1) | AU2021208482A1 (he) |
BR (1) | BR112022013756A2 (he) |
CA (1) | CA3166385A1 (he) |
CO (1) | CO2022009744A2 (he) |
IL (1) | IL294655A (he) |
MX (1) | MX2022008582A (he) |
PE (1) | PE20221465A1 (he) |
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WO2018152326A1 (en) | 2017-02-17 | 2018-08-23 | Denali Therapeutics Inc. | Engineered transferrin receptor binding polypeptides |
JP2021500857A (ja) | 2017-10-02 | 2021-01-14 | デナリ セラピューティクス インコーポレイテッドDenali Therapeutics Inc. | 酵素補充療法用酵素を含む融合タンパク質 |
BR112022012230A2 (pt) | 2019-12-23 | 2022-08-30 | Denali Therapeutics Inc | Variantes de progranulina |
IL302029A (he) | 2020-10-14 | 2023-06-01 | Denali Therapeutics Inc | חלבונים מאוחים המכילים אנזימים סולפוגלוקוסאמין סולפוהידרולאז ושיטות שלהם |
WO2023192288A1 (en) * | 2022-03-28 | 2023-10-05 | Denali Therapeutics Inc. | Monovalent anti-trem2 binding molecules and methods of use thereof |
WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
CN117624360A (zh) * | 2022-08-26 | 2024-03-01 | 南京融捷康生物科技有限公司 | 一种抗trem2的单域抗体及其用途 |
WO2024052343A1 (en) | 2022-09-06 | 2024-03-14 | Institut National de la Santé et de la Recherche Médicale | Trem-2 agonists for the treatment of marfan syndrome |
CN116041481B (zh) * | 2022-09-13 | 2024-01-19 | 北京湃德智健科技有限公司 | 一种用于检测trem2自身抗体的抗原多肽及其应用 |
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CN105254758A (zh) | 2009-03-05 | 2016-01-20 | Abbvie公司 | Il-17结合蛋白 |
KR102094022B1 (ko) | 2013-04-29 | 2020-03-30 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | 항-cd38 항체 및 감쇠 인터페론 알파-2b와의 융합체 |
CA2922979A1 (en) | 2013-09-03 | 2015-03-12 | Novimmune S.A. | Readily isolated bispecific binding molecules with native format having mutated constant regions |
CN105218669A (zh) | 2014-06-10 | 2016-01-06 | 河北翰林生物科技有限公司 | 制备抗人r47h-trem2突变体的人单克隆抗体的方法 |
EA201790342A1 (ru) | 2014-08-08 | 2017-07-31 | ЭЛЕКТОР ЭлЭлСи | Антитела к trem2 и способы их применения |
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KR20180068999A (ko) | 2015-10-06 | 2018-06-22 | 알렉터 엘엘씨 | 항-trem2 항체 및 그의 사용방법 |
WO2017147509A1 (en) | 2016-02-25 | 2017-08-31 | Marco Colonna | Compositions comprising trem2 and methods of use thereof |
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WO2018015573A2 (en) | 2016-07-22 | 2018-01-25 | Deutsches Zentrum Für Neurodegenerative Erkrankungen E.V. (Dzne) | Trem2 cleavage modulators and uses thereof |
JP7264482B2 (ja) | 2016-12-23 | 2023-04-25 | ブルーフィン バイオメディシン, インコーポレイテッド | 抗sez6l2抗体および抗体薬物コンジュゲート |
EP3570883A2 (en) | 2017-01-17 | 2019-11-27 | Yeda Research and Development Co. Ltd | Methods of treating neurodegenerative diseases by inducing disease-associated microglia (dam) cells |
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JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
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HUE062436T2 (hu) | 2017-08-03 | 2023-11-28 | Alector Llc | Anti-trem2 antitestek és alkalmazási módszereik |
SI3665192T1 (sl) * | 2017-08-10 | 2023-11-30 | Denali Therapeutics Inc. | Inženiring polipeptidov, ki se vežejo na receptorje za transferine |
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JP2021500857A (ja) | 2017-10-02 | 2021-01-14 | デナリ セラピューティクス インコーポレイテッドDenali Therapeutics Inc. | 酵素補充療法用酵素を含む融合タンパク質 |
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JP7397063B2 (ja) | 2018-08-16 | 2023-12-12 | デナリ セラピューティクス インコーポレイテッド | 操作された二重特異性タンパク質 |
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AU2021208482A1 (en) | 2022-07-21 |
PE20221465A1 (es) | 2022-09-21 |
KR20220131246A (ko) | 2022-09-27 |
JP2023512450A (ja) | 2023-03-27 |
BR112022013756A2 (pt) | 2022-10-11 |
CO2022009744A2 (es) | 2022-07-19 |
US11124567B2 (en) | 2021-09-21 |
US20210214438A1 (en) | 2021-07-15 |
US20220177576A1 (en) | 2022-06-09 |
EP4090682A1 (en) | 2022-11-23 |
MX2022008582A (es) | 2022-08-10 |
CN115279790A (zh) | 2022-11-01 |
CA3166385A1 (en) | 2021-07-22 |
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