IL293504A - Using kv7 potassium channel opener for pain treatment - Google Patents
Using kv7 potassium channel opener for pain treatmentInfo
- Publication number
- IL293504A IL293504A IL293504A IL29350422A IL293504A IL 293504 A IL293504 A IL 293504A IL 293504 A IL293504 A IL 293504A IL 29350422 A IL29350422 A IL 29350422A IL 293504 A IL293504 A IL 293504A
- Authority
- IL
- Israel
- Prior art keywords
- pain
- compound
- human
- dose
- administered
- Prior art date
Links
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
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- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Light Guides In General And Applications Therefor (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Applications Claiming Priority (3)
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| US201962945093P | 2019-12-06 | 2019-12-06 | |
| US201962948010P | 2019-12-13 | 2019-12-13 | |
| PCT/US2020/063471 WO2021113757A1 (en) | 2019-12-06 | 2020-12-04 | Use of a kv7 potassium channel opener for treating pain |
Publications (1)
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| IL293504A true IL293504A (en) | 2022-08-01 |
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| JP (1) | JP2023504166A (zh) |
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| PE (1) | PE20221169A1 (zh) |
| TW (1) | TW202133847A (zh) |
| WO (1) | WO2021113757A1 (zh) |
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| CN113698345B (zh) * | 2021-10-27 | 2022-02-01 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的化合物及其制备和应用 |
| EP4074696A4 (en) * | 2021-10-27 | 2024-01-31 | Shanghai Zhimeng Biopharma, Inc. | POTASSIUM CHANNEL REGULATOR COMPOUND, PRODUCTION AND USE THEREOF |
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| US8993593B2 (en) * | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| PT2061465E (pt) | 2006-08-23 | 2013-07-15 | Valeant Pharmaceuticals Int | Derivados de 4-(n-azacicloalquil)anilidas como moduladores do canal de potássio |
| WO2013067591A1 (en) * | 2011-11-10 | 2013-05-16 | Relevare Australia Pty Ltd | Topical formulations for pain management |
| US9248122B2 (en) * | 2012-11-28 | 2016-02-02 | Grünenthal GmbH | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators |
| SI3790548T1 (sl) * | 2018-05-11 | 2024-02-29 | Xenon Pharmaceuticals Inc. | Postopek za povečanje biološke razpoložljivosti in izpostavljenosti napetostno odvisnih odpiralcev kalijevih kanalačkov |
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| AU2020397173A1 (en) | 2022-06-23 |
| MX2022006877A (es) | 2022-07-11 |
| BR112022010733A2 (pt) | 2022-08-23 |
| TW202133847A (zh) | 2021-09-16 |
| CR20220318A (es) | 2022-10-07 |
| JP2023504166A (ja) | 2023-02-01 |
| PE20221169A1 (es) | 2022-07-25 |
| CA3159436A1 (en) | 2021-06-10 |
| CN114786658A (zh) | 2022-07-22 |
| WO2021113757A1 (en) | 2021-06-10 |
| EP4069211A1 (en) | 2022-10-12 |
| KR20220113411A (ko) | 2022-08-12 |
| CL2022001477A1 (es) | 2023-04-28 |
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