IL288782A - Sustained-release alpha-ketoglutarate preparations - Google Patents
Sustained-release alpha-ketoglutarate preparationsInfo
- Publication number
- IL288782A IL288782A IL288782A IL28878221A IL288782A IL 288782 A IL288782 A IL 288782A IL 288782 A IL288782 A IL 288782A IL 28878221 A IL28878221 A IL 28878221A IL 288782 A IL288782 A IL 288782A
- Authority
- IL
- Israel
- Prior art keywords
- ketoglutarate
- sustained
- alpha
- release compositions
- compositions
- Prior art date
Links
- KPGXRSRHYNQIFN-UHFFFAOYSA-L 2-oxoglutarate(2-) Chemical group [O-]C(=O)CCC(=O)C([O-])=O KPGXRSRHYNQIFN-UHFFFAOYSA-L 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000013268 sustained release Methods 0.000 title 1
- 239000012730 sustained-release form Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962859595P | 2019-06-10 | 2019-06-10 | |
| US201962929024P | 2019-10-31 | 2019-10-31 | |
| PCT/US2020/036987 WO2020252014A1 (en) | 2019-06-10 | 2020-06-10 | Sustained-release compositions of alpha-ketoglutarate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL288782A true IL288782A (en) | 2022-02-01 |
Family
ID=73781275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL288782A IL288782A (en) | 2019-06-10 | 2021-12-08 | Sustained-release alpha-ketoglutarate preparations |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220265586A1 (enExample) |
| EP (1) | EP3980001B1 (enExample) |
| JP (2) | JP7751291B2 (enExample) |
| KR (1) | KR20220044478A (enExample) |
| CN (1) | CN114126601B (enExample) |
| BR (1) | BR112021024952A2 (enExample) |
| CA (1) | CA3142494A1 (enExample) |
| DK (1) | DK3980001T3 (enExample) |
| IL (1) | IL288782A (enExample) |
| TW (1) | TWI869410B (enExample) |
| WO (1) | WO2020252014A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7499259B2 (ja) * | 2018-09-25 | 2024-06-13 | ポンス デ レオン ヘルス デジグネイテッド アクティビティ カンパニー | αケトグルタル酸カルシウムを製造するためのプロセス |
| MX2024008182A (es) * | 2021-12-29 | 2024-09-24 | Jrs Pharma Gmbh & Co Kg | Lubricante para productos farmacéuticos y nutracéuticos. |
| WO2024123738A1 (en) * | 2022-12-06 | 2024-06-13 | Ponce De Leon Health Designated Activity Company | Compositions and methods for treating diseases responsive to akg-vitamin b coadministration |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4389393A (en) * | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US6905707B2 (en) * | 1998-05-28 | 2005-06-14 | Medical Research Institute | Controlled release arginine alpha ketoglutarate |
| US8293277B2 (en) * | 1998-10-01 | 2012-10-23 | Alkermes Pharma Ireland Limited | Controlled-release nanoparticulate compositions |
| CO5140079A1 (es) * | 1998-10-14 | 2002-03-22 | Novartis Ag | Composicion farmaceutica de liberacion sostenida y metodo para liberar un agente farmaceuticamente activo de liberacion sostenida y metodo para liberar un agente far- maceuticamente activo |
| CN100400042C (zh) | 1999-12-03 | 2008-07-09 | 聚合化学股份公司 | 制备生物利用度改善的麦角生物碱持续释放药物组合物的方法及其组合物 |
| JP4169596B2 (ja) * | 2000-12-20 | 2008-10-22 | アルコン、インコーポレイテッド | 白内障を液化破壊により取り除くための溶液 |
| US20060029668A1 (en) | 2002-10-24 | 2006-02-09 | Ron Eyal S | Sustained release L-arginine formulations and methods of manufacture and use |
| CA2574597A1 (en) * | 2004-08-09 | 2006-02-16 | Cancer Research Technology Limited | Alpha-ketoglutarates and their use as therapeutic agents |
| FR2967578B1 (fr) | 2010-11-18 | 2012-12-28 | Advicenne Pharma | Composition pharmaceutique comportant des sels de citrate et de bicarbonate, et son utilisation pour le traitement de la cystinurie |
| ITBO20120226A1 (it) * | 2012-04-24 | 2013-10-25 | Alfa Wassermann Spa | Composizioni comprendenti ornitina alfa-chetoglutarato, processi per il loro ottenimento e il loro uso. |
| MX377119B (es) * | 2013-06-06 | 2025-03-07 | Amip Llc | Un sistema de dosis no alimenticia suministrable oralmente que comprende hierro y un agente. |
| ITFI20130184A1 (it) | 2013-08-01 | 2015-02-02 | Valpharma Internat S P A | Una formulazione farmaceutica di gliclazide a rilascio modificato, somministrabile per via orale, e suo metodo di produzione. |
| CN108653221B (zh) * | 2015-06-03 | 2021-09-07 | 南京三迭纪医药科技有限公司 | 药品剂型及其使用 |
| EP3518915A4 (en) * | 2016-09-30 | 2020-04-15 | The Regents of the University of California | ALPHA KETOBUTYRATE, ALPHA KETOGLUTARATE AND 2-HYDROXYBUTYRATE FOR STIMULATING HAIR GROWTH |
| KR20180062063A (ko) * | 2016-11-30 | 2018-06-08 | (주) 메티메디제약 | 서방형 항암용 약학 조성물 |
| MX2017004010A (es) * | 2017-03-27 | 2018-02-09 | Antonio Hernandez Miramontes Jorge | Mezcla de oxalacetato, alfacetoglutarato, ácido tartánico y sales de lactato de calcio y sodio, para tratar pacientes con insuficiencia renal crónica. |
| KR102643567B1 (ko) | 2017-04-25 | 2024-03-05 | 버크 인스티튜트 포 리서치 온 에이징 | 수명 및 건강수명을 연장시키기 위한 제제 |
-
2020
- 2020-06-10 EP EP20822078.0A patent/EP3980001B1/en active Active
- 2020-06-10 JP JP2021573428A patent/JP7751291B2/ja active Active
- 2020-06-10 TW TW109119483A patent/TWI869410B/zh active
- 2020-06-10 US US17/617,422 patent/US20220265586A1/en active Pending
- 2020-06-10 WO PCT/US2020/036987 patent/WO2020252014A1/en not_active Ceased
- 2020-06-10 DK DK20822078.0T patent/DK3980001T3/da active
- 2020-06-10 CA CA3142494A patent/CA3142494A1/en active Pending
- 2020-06-10 KR KR1020227000256A patent/KR20220044478A/ko active Pending
- 2020-06-10 BR BR112021024952A patent/BR112021024952A2/pt unknown
- 2020-06-10 CN CN202080052370.3A patent/CN114126601B/zh active Active
-
2021
- 2021-12-08 IL IL288782A patent/IL288782A/en unknown
-
2025
- 2025-05-14 JP JP2025080904A patent/JP2025124683A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3980001B1 (en) | 2025-08-27 |
| CN114126601B (zh) | 2025-07-15 |
| CN114126601A (zh) | 2022-03-01 |
| JP2025124683A (ja) | 2025-08-26 |
| WO2020252014A1 (en) | 2020-12-17 |
| TWI869410B (zh) | 2025-01-11 |
| KR20220044478A (ko) | 2022-04-08 |
| EP3980001A4 (en) | 2023-06-21 |
| JP2022537685A (ja) | 2022-08-29 |
| US20220265586A1 (en) | 2022-08-25 |
| CA3142494A1 (en) | 2020-12-17 |
| EP3980001A1 (en) | 2022-04-13 |
| TW202112362A (zh) | 2021-04-01 |
| JP7751291B2 (ja) | 2025-10-08 |
| BR112021024952A2 (pt) | 2022-02-15 |
| DK3980001T3 (da) | 2025-12-01 |
| AU2020292278A1 (en) | 2022-01-06 |
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