JP7751291B2 - アルファ－ケトグルタル酸塩の持続放出組成物 - Google Patents

アルファ－ケトグルタル酸塩の持続放出組成物

Info

Publication number
JP7751291B2
JP7751291B2 JP2021573428A JP2021573428A JP7751291B2 JP 7751291 B2 JP7751291 B2 JP 7751291B2 JP 2021573428 A JP2021573428 A JP 2021573428A JP 2021573428 A JP2021573428 A JP 2021573428A JP 7751291 B2 JP7751291 B2 JP 7751291B2
Authority
JP
Japan
Prior art keywords
composition
ketoglutarate
amount
release
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021573428A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022537685A (ja
JPWO2020252014A5 (enExample
Inventor
ユージーン ペレイラ，デイビッド
コナー，スマナ
Original Assignee
ポンス デ レオン ヘルス デジクネイテッド アクティビティ カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ポンス デ レオン ヘルス デジクネイテッド アクティビティ カンパニー filed Critical ポンス デ レオン ヘルス デジクネイテッド アクティビティ カンパニー
Publication of JP2022537685A publication Critical patent/JP2022537685A/ja
Publication of JPWO2020252014A5 publication Critical patent/JPWO2020252014A5/ja
Priority to JP2025080904A priority Critical patent/JP2025124683A/ja
Application granted granted Critical
Publication of JP7751291B2 publication Critical patent/JP7751291B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
JP2021573428A 2019-06-10 2020-06-10 アルファ－ケトグルタル酸塩の持続放出組成物 Active JP7751291B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025080904A JP2025124683A (ja) 2019-06-10 2025-05-14 アルファ－ケトグルタル酸塩の持続放出組成物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962859595P 2019-06-10 2019-06-10
US62/859,595 2019-06-10
US201962929024P 2019-10-31 2019-10-31
US62/929,024 2019-10-31
PCT/US2020/036987 WO2020252014A1 (en) 2019-06-10 2020-06-10 Sustained-release compositions of alpha-ketoglutarate

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025080904A Division JP2025124683A (ja) 2019-06-10 2025-05-14 アルファ－ケトグルタル酸塩の持続放出組成物

Publications (3)

Publication Number Publication Date
JP2022537685A JP2022537685A (ja) 2022-08-29
JPWO2020252014A5 JPWO2020252014A5 (enExample) 2023-06-16
JP7751291B2 true JP7751291B2 (ja) 2025-10-08

Family

ID=73781275

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021573428A Active JP7751291B2 (ja) 2019-06-10 2020-06-10 アルファ－ケトグルタル酸塩の持続放出組成物
JP2025080904A Pending JP2025124683A (ja) 2019-06-10 2025-05-14 アルファ－ケトグルタル酸塩の持続放出組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025080904A Pending JP2025124683A (ja) 2019-06-10 2025-05-14 アルファ－ケトグルタル酸塩の持続放出組成物

Country Status (11)

Country Link
US (1) US20220265586A1 (enExample)
EP (1) EP3980001B1 (enExample)
JP (2) JP7751291B2 (enExample)
KR (1) KR20220044478A (enExample)
CN (1) CN114126601B (enExample)
BR (1) BR112021024952A2 (enExample)
CA (1) CA3142494A1 (enExample)
DK (1) DK3980001T3 (enExample)
IL (1) IL288782A (enExample)
TW (1) TWI869410B (enExample)
WO (1) WO2020252014A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7499259B2 (ja) * 2018-09-25 2024-06-13 ポンス デ レオン ヘルス デジグネイテッド アクティビティ カンパニー αケトグルタル酸カルシウムを製造するためのプロセス
MX2024008182A (es) * 2021-12-29 2024-09-24 Jrs Pharma Gmbh & Co Kg Lubricante para productos farmacéuticos y nutracéuticos.
WO2024123738A1 (en) * 2022-12-06 2024-06-13 Ponce De Leon Health Designated Activity Company Compositions and methods for treating diseases responsive to akg-vitamin b coadministration

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003515549A (ja) 1999-12-03 2003-05-07 ポリケム・ソシエテ・アノニム バイオアベイラビリティの向上した麦角アルカロイドの徐放性医薬組成物の製造法及びその組成物
JP2008536858A (ja) 2005-04-15 2008-09-11 パルメット ファーマシューティカルズ， エルエルシー 徐放性ｌ−アルギニン調合物並びにその製造及び使用法
JP2013542975A (ja) 2010-11-18 2013-11-28 アドビセンヌ クエン酸及び重炭酸塩を含んでなる医薬組成物、並びにシスチン尿症を治療するためのこれらの使用
JP2016527261A (ja) 2013-08-01 2016-09-08 ヴァルファルマ インターナショナル ソチエタ ペル アツィオーニ グリクラジドを含有する放出調節医薬品製剤
JP2020517689A (ja) 2017-04-25 2020-06-18 バック インスティテュート フォー リサーチ オン エイジング 寿命および健康寿命を延ばすための製剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US6905707B2 (en) * 1998-05-28 2005-06-14 Medical Research Institute Controlled release arginine alpha ketoglutarate
US8293277B2 (en) * 1998-10-01 2012-10-23 Alkermes Pharma Ireland Limited Controlled-release nanoparticulate compositions
CO5140079A1 (es) * 1998-10-14 2002-03-22 Novartis Ag Composicion farmaceutica de liberacion sostenida y metodo para liberar un agente farmaceuticamente activo de liberacion sostenida y metodo para liberar un agente far- maceuticamente activo
JP4169596B2 (ja) * 2000-12-20 2008-10-22 アルコン、インコーポレイテッド 白内障を液化破壊により取り除くための溶液
CA2574597A1 (en) * 2004-08-09 2006-02-16 Cancer Research Technology Limited Alpha-ketoglutarates and their use as therapeutic agents
ITBO20120226A1 (it) * 2012-04-24 2013-10-25 Alfa Wassermann Spa Composizioni comprendenti ornitina alfa-chetoglutarato, processi per il loro ottenimento e il loro uso.
MX377119B (es) * 2013-06-06 2025-03-07 Amip Llc Un sistema de dosis no alimenticia suministrable oralmente que comprende hierro y un agente.
CN108653221B (zh) * 2015-06-03 2021-09-07 南京三迭纪医药科技有限公司 药品剂型及其使用
EP3518915A4 (en) * 2016-09-30 2020-04-15 The Regents of the University of California ALPHA KETOBUTYRATE, ALPHA KETOGLUTARATE AND 2-HYDROXYBUTYRATE FOR STIMULATING HAIR GROWTH
KR20180062063A (ko) * 2016-11-30 2018-06-08 (주) 메티메디제약 서방형 항암용 약학 조성물
MX2017004010A (es) * 2017-03-27 2018-02-09 Antonio Hernandez Miramontes Jorge Mezcla de oxalacetato, alfacetoglutarato, ácido tartánico y sales de lactato de calcio y sodio, para tratar pacientes con insuficiencia renal crónica.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003515549A (ja) 1999-12-03 2003-05-07 ポリケム・ソシエテ・アノニム バイオアベイラビリティの向上した麦角アルカロイドの徐放性医薬組成物の製造法及びその組成物
JP2008536858A (ja) 2005-04-15 2008-09-11 パルメット ファーマシューティカルズ， エルエルシー 徐放性ｌ−アルギニン調合物並びにその製造及び使用法
JP2013542975A (ja) 2010-11-18 2013-11-28 アドビセンヌ クエン酸及び重炭酸塩を含んでなる医薬組成物、並びにシスチン尿症を治療するためのこれらの使用
JP2016527261A (ja) 2013-08-01 2016-09-08 ヴァルファルマ インターナショナル ソチエタ ペル アツィオーニ グリクラジドを含有する放出調節医薬品製剤
JP2020517689A (ja) 2017-04-25 2020-06-18 バック インスティテュート フォー リサーチ オン エイジング 寿命および健康寿命を延ばすための製剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Drug Dev Ind Pharm，1989年，Vol. 15，pp. 975-999

Also Published As

Publication number Publication date
EP3980001B1 (en) 2025-08-27
CN114126601B (zh) 2025-07-15
CN114126601A (zh) 2022-03-01
JP2025124683A (ja) 2025-08-26
WO2020252014A1 (en) 2020-12-17
TWI869410B (zh) 2025-01-11
KR20220044478A (ko) 2022-04-08
EP3980001A4 (en) 2023-06-21
JP2022537685A (ja) 2022-08-29
US20220265586A1 (en) 2022-08-25
CA3142494A1 (en) 2020-12-17
EP3980001A1 (en) 2022-04-13
TW202112362A (zh) 2021-04-01
BR112021024952A2 (pt) 2022-02-15
IL288782A (en) 2022-02-01
DK3980001T3 (da) 2025-12-01
AU2020292278A1 (en) 2022-01-06

Similar Documents

Publication Publication Date Title
US10973769B2 (en) Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
JP2025124683A (ja) アルファ－ケトグルタル酸塩の持続放出組成物
US10555907B2 (en) Controlled-release solid dosage forms of mesalamine
AU2011222856A1 (en) Use of levodopa, carbidopa and entacapone for treating Parkinson's disease
JP2017149725A (ja) ヒドロモルホンおよびナロキソンを含む医薬組成物
US12178918B2 (en) Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
AU2020223515B2 (en) Afabicin formulation, method for making the same
AU2020292278B2 (en) Sustained-release compositions of alpha-ketoglutarate
HK40071632A (en) Sustained-release compositions of alpha-ketoglutarate
EP2543363A1 (en) Sustained release pharmaceutical oral solid dosage forms of dronedarone or one of its pharmaceutically acceptable salts

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230608

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230608

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20240524

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240611

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20240909

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20241211

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20250114

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250514

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20250819

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20250918

R150 Certificate of patent or registration of utility model

Ref document number: 7751291

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150