IL285452B2 - A new recombinant diamine oxidase and its use for the treatment of diseases characterized by excess histamine - Google Patents

A new recombinant diamine oxidase and its use for the treatment of diseases characterized by excess histamine

Info

Publication number
IL285452B2
IL285452B2 IL285452A IL28545221A IL285452B2 IL 285452 B2 IL285452 B2 IL 285452B2 IL 285452 A IL285452 A IL 285452A IL 28545221 A IL28545221 A IL 28545221A IL 285452 B2 IL285452 B2 IL 285452B2
Authority
IL
Israel
Prior art keywords
dao
specifically
recombinant
amino acid
seq
Prior art date
Application number
IL285452A
Other languages
English (en)
Hebrew (he)
Other versions
IL285452A (en
IL285452B1 (en
Inventor
Thomas B?HM
Bernd Jilma
Nicole Borth
Elisabeth Gludovacz
Original Assignee
Universit?T F?R Bodenkultur Wien
Medizinische Universit?T Wien
Thomas B?HM
Bernd Jilma
Nicole Borth
Elisabeth Gludovacz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universit?T F?R Bodenkultur Wien, Medizinische Universit?T Wien, Thomas B?HM, Bernd Jilma, Nicole Borth, Elisabeth Gludovacz filed Critical Universit?T F?R Bodenkultur Wien
Publication of IL285452A publication Critical patent/IL285452A/en
Publication of IL285452B1 publication Critical patent/IL285452B1/en
Publication of IL285452B2 publication Critical patent/IL285452B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
    • C12Y104/03—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12Y104/03022—Diamine oxidase (1.4.3.22)
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/20—Sequence assembly
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G16B35/10—Design of libraries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Library & Information Science (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
IL285452A 2019-02-19 2020-02-18 A new recombinant diamine oxidase and its use for the treatment of diseases characterized by excess histamine IL285452B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19157932 2019-02-19
PCT/EP2020/054197 WO2020169577A1 (en) 2019-02-19 2020-02-18 New recombinant diamine oxidase and its use for the treatment of diseases characterized by excess histamine

Publications (3)

Publication Number Publication Date
IL285452A IL285452A (en) 2021-09-30
IL285452B1 IL285452B1 (en) 2025-03-01
IL285452B2 true IL285452B2 (en) 2025-07-01

Family

ID=65493995

Family Applications (1)

Application Number Title Priority Date Filing Date
IL285452A IL285452B2 (en) 2019-02-19 2020-02-18 A new recombinant diamine oxidase and its use for the treatment of diseases characterized by excess histamine

Country Status (14)

Country Link
US (1) US20220145269A1 (enExample)
EP (1) EP3927817B1 (enExample)
JP (1) JP7792252B2 (enExample)
KR (1) KR20210132650A (enExample)
CN (1) CN113785052B (enExample)
AU (1) AU2020225319B2 (enExample)
BR (1) BR112021015865A2 (enExample)
CA (1) CA3130751A1 (enExample)
EA (1) EA202192305A1 (enExample)
ES (1) ES3041133T3 (enExample)
IL (1) IL285452B2 (enExample)
MX (1) MX2021010050A (enExample)
SG (1) SG11202107659SA (enExample)
WO (1) WO2020169577A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10947552B1 (en) 2020-09-30 2021-03-16 Alpine Roads, Inc. Recombinant fusion proteins for producing milk proteins in plants
WO2022072718A1 (en) 2020-09-30 2022-04-07 Nobell Foods, Inc. Recombinant milk proteins and food compositions comprising the same
US10894812B1 (en) 2020-09-30 2021-01-19 Alpine Roads, Inc. Recombinant milk proteins
EP4496488A4 (en) * 2022-03-21 2025-11-26 Cedars Sinai Medical Center METHODS AND COMPOSITIONS FOR THE SUPPRESSION OF BIOGENIC AMINES PRODUCED BY THE INTESTINAL MICROBIOME
IL317379A (en) * 2022-06-03 2025-02-01 Oyster Point Pharma Inc AAV vector encoding diamine oxidase and its uses
EP4782002A1 (en) * 2025-01-27 2026-07-29 DR Healthcare S.L.U. Diamine oxidase (dao) for use in the treatment of infertility
CN121975758B (zh) * 2026-04-02 2026-07-14 华中科技大学同济医学院附属同济医院 组胺氧化酶蛋白及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK402785D0 (da) * 1985-09-03 1985-09-03 Syn Tek Ab Fremgangsmaade til fremstilling af et enzym
US6075007A (en) * 1997-07-17 2000-06-13 Regeneron Pharmaceuticals, Inc. Modified noggin polypeptide and compositions
IT1317067B1 (it) * 2000-11-29 2003-05-26 Univ Roma Istaminasi di origine vegetale nel trattamento dello shock allergico esettico e nell'asma allergico.
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
CA2536016C (en) * 2002-08-16 2017-01-10 Paul L. Deangelis Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20050255114A1 (en) * 2003-04-07 2005-11-17 Nuvelo, Inc. Methods and diagnosis for the treatment of preeclampsia
AT502098B8 (de) * 2004-07-07 2007-06-15 Albert Dr Missbichler Diaminooxidase-hältige zusammensetzung
CA2660286A1 (en) * 2006-08-09 2008-02-21 Homestead Clinical Corporation Organ-specific proteins and methods of their use
WO2012028891A1 (en) * 2010-09-02 2012-03-08 Debreceni Egyetem Perorally applicable preparation containing histaminase of vegetable origin, resistant to pepsin and trypsin and a process for producing it
JP2014518632A (ja) * 2011-06-01 2014-08-07 モアハウス スクール オブ メディスン ケモカイン−免疫グロブリン融合ポリペプチド、組成物、その作製および使用の方法
AU2015332533B2 (en) * 2014-10-14 2018-08-30 Halozyme, Inc. Compositions of adenosine deaminase-2 (ADA2), variants thereof and methods of using same
WO2023122254A2 (en) * 2021-12-22 2023-06-29 The Board Of Trustees Of The Leland Stanford Junior University Methods to elicit desire to mate and mating behavior

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AARON P. MCGRATH ET AL., AARON P. MCGRATH, 20 October 2009 (2009-10-20) *
BRADLEY O. ELMORE ET AL., BRADLEY O. ELMORE ET AL., 13 February 2002 (2002-02-13) *

Also Published As

Publication number Publication date
ES3041133T3 (en) 2025-11-07
EP3927817C0 (en) 2025-08-20
AU2020225319B2 (en) 2025-05-29
KR20210132650A (ko) 2021-11-04
US20220145269A1 (en) 2022-05-12
BR112021015865A2 (pt) 2021-10-05
SG11202107659SA (en) 2021-09-29
WO2020169577A1 (en) 2020-08-27
CA3130751A1 (en) 2020-08-27
EP3927817B1 (en) 2025-08-20
CN113785052A (zh) 2021-12-10
CN113785052B (zh) 2024-06-28
IL285452A (en) 2021-09-30
MX2021010050A (es) 2021-09-21
JP2022520862A (ja) 2022-04-01
EP3927817A1 (en) 2021-12-29
AU2020225319A1 (en) 2021-10-14
IL285452B1 (en) 2025-03-01
JP7792252B2 (ja) 2025-12-25
EA202192305A1 (ru) 2021-12-08

Similar Documents

Publication Publication Date Title
EP3927817B1 (en) New recombinant diamine oxidase and its use for the treatment of diseases characterized by excess histamine
JP6810190B2 (ja) Ｆｇｆ２１突然変異体及びその使用
AU2017294551B2 (en) Soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides and uses thereof
US20200040051A1 (en) Fibroblast growth factor (fgf) 1 with mutation in the heparin binding domain and methods of use to reduce blood glucose
BRPI1011404B1 (pt) Polipeptídeos mutantes fgf21, polipeptídeo de fusão, multímero, composição farmacêutica, ácido nucleico isolado, vetor e célula hospedeira
JP2019059768A (ja) ホモシスチン尿症を処置するためのシスタチオニンβ−シンターゼ酵素
US20160237133A1 (en) Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use
ES3037618T3 (en) Proteins with diagnostic and therapeutic uses
US20180057554A1 (en) Fibroblast growth factor (fgf) 1 mutants and methods of use to reduce blood glucose
US20190151416A1 (en) Fibroblast growth factor (fgf) 1 proteins with glucose lowering ability and reduced mitogenicity
US20170291931A1 (en) Fgf2 truncations and mutants and uses thereof
US20190276510A1 (en) Use of fibroblast growth factor 1 (fgf1)-vagus nerve targeting chimeric proteins to treat hyperglycemia
US20150087596A1 (en) Huwentoxin-iv variants and methods of use
US20180319857A1 (en) Fgf2 truncations and mutants and uses thereof
US20230097335A1 (en) Fibroblast growth factor 1 (fgf1) mutant proteins that selectively activate fgfr1b to reduce blood glucose
HK40064258A (en) New recombinant diamine oxidase and its use for the treatment of diseases characterized by excess histamine
US6893844B1 (en) DNA encoding a new human hepatoma derived growth factor and producing method thereof
HK40064258B (en) New recombinant diamine oxidase and its use for the treatment of diseases characterized by excess histamine
WO2014014819A2 (en) Methods of treating glucose metabolism disorders
EP3144007A1 (en) Peptide for use in the treatment of disease caused by clostridium neurotoxins
WO2014014816A2 (en) Methods of treating glucose metabolism disorders
CN1318100A (zh) 新的人肝癌细胞衍生生长因子编码序列、其编码的多肽及制备方法
Pan The delta subunit of mitochondrial ATP synthase F (0) F (1): Characterization and novel insights into both its location within F (1) and its phosphorylation in response to platelet-derived growth factor