IL279674A - חומרי קומרין אקסוציקליים מותמרי אמין ושימושם כתגים פלורצנטיים - Google Patents
חומרי קומרין אקסוציקליים מותמרי אמין ושימושם כתגים פלורצנטייםInfo
- Publication number
- IL279674A IL279674A IL279674A IL27967420A IL279674A IL 279674 A IL279674 A IL 279674A IL 279674 A IL279674 A IL 279674A IL 27967420 A IL27967420 A IL 27967420A IL 279674 A IL279674 A IL 279674A
- Authority
- IL
- Israel
- Prior art keywords
- fluorescent labels
- coumarin compounds
- exocyclic amine
- substituted coumarin
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B57/00—Other synthetic dyes of known constitution
- C09B57/02—Coumarine dyes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B55/00—Azomethine dyes
- C09B55/009—Azomethine dyes, the C-atom of the group -C=N- being part of a ring (Image)
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962812837P | 2019-03-01 | 2019-03-01 | |
| PCT/EP2020/055248 WO2020178162A1 (en) | 2019-03-01 | 2020-02-28 | Exocyclic amine-substituted coumarin compounds and their uses as fluorescent labels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL279674A true IL279674A (he) | 2021-03-01 |
Family
ID=69743223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL279674A IL279674A (he) | 2019-03-01 | 2020-12-22 | חומרי קומרין אקסוציקליים מותמרי אמין ושימושם כתגים פלורצנטיים |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11390753B2 (he) |
| EP (1) | EP3931263A1 (he) |
| JP (1) | JP2022522553A (he) |
| KR (1) | KR20210134209A (he) |
| CN (1) | CN112654681B (he) |
| AU (1) | AU2020230955A1 (he) |
| BR (1) | BR112020026528B1 (he) |
| CA (1) | CA3103900A1 (he) |
| IL (1) | IL279674A (he) |
| MX (1) | MX2020013384A (he) |
| SG (1) | SG11202012555UA (he) |
| WO (1) | WO2020178162A1 (he) |
| ZA (1) | ZA202007842B (he) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3931263A1 (en) | 2019-03-01 | 2022-01-05 | Illumina Cambridge Limited | Exocyclic amine substituted coumarin compounds and their uses as fluorescent labels |
| KR20220107231A (ko) | 2019-11-27 | 2022-08-02 | 일루미나 케임브리지 리미티드 | 사이클로옥타테트라엔 함유 염료 및 조성물 |
| US20220195516A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Methods, systems and compositions for nucleic acid sequencing |
| US20220195518A1 (en) | 2020-12-22 | 2022-06-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing |
| KR20240009435A (ko) | 2021-05-20 | 2024-01-22 | 일루미나, 인코포레이티드 | 합성에 의한 시퀀싱을 위한 조성물 및 방법 |
| WO2023186815A1 (en) | 2022-03-28 | 2023-10-05 | Illumina Cambridge Limited | Labeled avidin and methods for sequencing |
| AU2023246851A1 (en) | 2022-03-31 | 2024-01-18 | Illumina, Inc. | Compositions and methods for improving sequencing signals |
| CA3222797A1 (en) | 2022-03-31 | 2023-10-05 | Ramesh NEELAKANDAN | Nucleosides and nucleotides with 3' vinyl blocking group |
| US20230383342A1 (en) | 2022-05-31 | 2023-11-30 | Illumina Cambridge Limited | Compositions and methods for nucleic acid sequencing |
| US20240140939A1 (en) | 2022-09-30 | 2024-05-02 | Illumina Cambridge Limited | Compositions and methods for reducing photo damage during sequencing |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2925546A1 (de) | 1979-06-25 | 1981-01-15 | Bayer Ag | Cumarinverbindungen sowie deren herstellung und verwendung als farbstoffe |
| US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
| JP2999841B2 (ja) * | 1991-04-03 | 2000-01-17 | 三井化学株式会社 | 発光スクリーン用樹脂組成物 |
| ATE147400T1 (de) | 1991-08-13 | 1997-01-15 | Bayer Ag | Fluoreszierendes etikett |
| DE4302459A1 (de) * | 1993-01-29 | 1994-08-04 | Bayer Ag | Sulfocumarinhaltige Nukleotide und deren Verwendung in Nachweisverfahren für Nukleinsäuren |
| US5846719A (en) | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
| JP3838695B2 (ja) | 1996-04-25 | 2006-10-25 | 三井化学株式会社 | クマリン化合物およびその用途 |
| DE69837913T2 (de) | 1997-04-01 | 2008-02-07 | Solexa Ltd., Saffron Walden | Verfahren zur vervielfältigung von nukleinsäure |
| US6465178B2 (en) | 1997-09-30 | 2002-10-15 | Surmodics, Inc. | Target molecule attachment to surfaces |
| US6485944B1 (en) | 1997-10-10 | 2002-11-26 | President And Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
| GB0002310D0 (en) | 2000-02-01 | 2000-03-22 | Solexa Ltd | Polynucleotide sequencing |
| JP2002521064A (ja) | 1998-07-30 | 2002-07-16 | ソレックサ リミテッド | アレイ生体分子およびシークエンシングにおけるその使用 |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| US6472541B2 (en) | 1998-11-20 | 2002-10-29 | The Regents Of The University Of California | Protecting groups with increased photosensitivities |
| US6391937B1 (en) | 1998-11-25 | 2002-05-21 | Motorola, Inc. | Polyacrylamide hydrogels and hydrogel arrays made from polyacrylamide reactive prepolymers |
| US6664061B2 (en) | 1999-06-25 | 2003-12-16 | Amersham Biosciences Ab | Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix |
| US6372813B1 (en) | 1999-06-25 | 2002-04-16 | Motorola | Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays |
| AU2001279244A1 (en) | 2000-08-09 | 2002-02-18 | Motorola, Inc. | The use and evaluation of a (2+2) photocycloaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix |
| EP2325263B1 (en) | 2000-09-29 | 2013-01-23 | Life Technologies Corporation | Modified carbocyanine dyes and their conjugates |
| GB0205281D0 (en) * | 2002-03-06 | 2002-04-17 | Novartis Ag | Organic compounds |
| EP1560838B1 (en) | 2002-08-23 | 2009-05-13 | Illumina Cambridge Limited | Labelled nucleotides |
| EP3795577A1 (en) | 2002-08-23 | 2021-03-24 | Illumina Cambridge Limited | Modified nucleotides |
| DE10258150A1 (de) | 2002-12-10 | 2004-07-08 | Dyomics Gmbh | Hydrophile Marker auf der Basis von Benzopyrylo-Polymethinen |
| GB0321306D0 (en) | 2003-09-11 | 2003-10-15 | Solexa Ltd | Modified polymerases for improved incorporation of nucleotide analogues |
| GB0326073D0 (en) | 2003-11-07 | 2003-12-10 | Solexa Ltd | Improvements in or relating to polynucleotide arrays |
| EP2789383B1 (en) | 2004-01-07 | 2023-05-03 | Illumina Cambridge Limited | Molecular arrays |
| JP4990886B2 (ja) | 2005-05-10 | 2012-08-01 | ソレックサ リミテッド | 改良ポリメラーゼ |
| GB0517097D0 (en) | 2005-08-19 | 2005-09-28 | Solexa Ltd | Modified nucleosides and nucleotides and uses thereof |
| HRP20211523T1 (hr) | 2011-09-23 | 2021-12-24 | Illumina, Inc. | Pripravci za sekvenciranje nukleinske kiseline |
| JP6110876B2 (ja) | 2011-12-30 | 2017-04-05 | コンパニー ゼネラール デ エタブリッスマン ミシュラン | 多層薄膜からの改善したインナーライナーバリア |
| MX352861B (es) * | 2011-12-30 | 2017-12-13 | Ptc Therapeutics Inc | Compuestos para tratar la atrofia muscular espinal. |
| JP6174881B2 (ja) | 2012-04-04 | 2017-08-02 | 住友化学株式会社 | 着色硬化性樹脂組成物 |
| US9012022B2 (en) | 2012-06-08 | 2015-04-21 | Illumina, Inc. | Polymer coatings |
| AU2013380645B2 (en) | 2013-03-08 | 2018-03-15 | Illumina Cambridge Ltd | Polymethine compounds and their use as fluorescent labels |
| KR101874680B1 (ko) | 2013-03-15 | 2018-07-04 | 일루미나 케임브리지 리미티드 | 변형된 뉴클레오사이드 또는 뉴클레오타이드 |
| GB201414098D0 (en) | 2014-08-08 | 2014-09-24 | Illumina Cambridge Ltd | Modified nucleotide linkers |
| GB201516987D0 (en) | 2015-09-25 | 2015-11-11 | Illumina Cambridge Ltd | Polymethine compounds and their use as fluorescent labels |
| US10385214B2 (en) | 2016-09-30 | 2019-08-20 | Illumina Cambridge Limited | Fluorescent dyes and their uses as biomarkers |
| GB201711219D0 (en) | 2017-07-12 | 2017-08-23 | Illumina Cambridge Ltd | Short pendant arm linkers for nucleotides in sequencing applications |
| EP3931263A1 (en) | 2019-03-01 | 2022-01-05 | Illumina Cambridge Limited | Exocyclic amine substituted coumarin compounds and their uses as fluorescent labels |
-
2020
- 2020-02-28 EP EP20709145.5A patent/EP3931263A1/en active Pending
- 2020-02-28 CA CA3103900A patent/CA3103900A1/en active Pending
- 2020-02-28 BR BR112020026528-4A patent/BR112020026528B1/pt active IP Right Grant
- 2020-02-28 SG SG11202012555UA patent/SG11202012555UA/en unknown
- 2020-02-28 JP JP2020572446A patent/JP2022522553A/ja active Pending
- 2020-02-28 KR KR1020207036679A patent/KR20210134209A/ko unknown
- 2020-02-28 MX MX2020013384A patent/MX2020013384A/es unknown
- 2020-02-28 AU AU2020230955A patent/AU2020230955A1/en active Pending
- 2020-02-28 CN CN202080003516.5A patent/CN112654681B/zh active Active
- 2020-02-28 US US16/805,015 patent/US11390753B2/en active Active
- 2020-02-28 WO PCT/EP2020/055248 patent/WO2020178162A1/en active Application Filing
- 2020-12-15 ZA ZA2020/07842A patent/ZA202007842B/en unknown
- 2020-12-22 IL IL279674A patent/IL279674A/he unknown
-
2022
- 2022-07-01 US US17/856,307 patent/US11884825B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20210134209A (ko) | 2021-11-09 |
| US11390753B2 (en) | 2022-07-19 |
| WO2020178162A8 (en) | 2021-04-22 |
| US20200277529A1 (en) | 2020-09-03 |
| BR112020026528B1 (pt) | 2024-02-15 |
| US11884825B2 (en) | 2024-01-30 |
| BR112020026528A2 (pt) | 2021-09-08 |
| WO2020178162A1 (en) | 2020-09-10 |
| CA3103900A1 (en) | 2020-09-10 |
| US20230022437A1 (en) | 2023-01-26 |
| EP3931263A1 (en) | 2022-01-05 |
| AU2020230955A1 (en) | 2021-01-07 |
| SG11202012555UA (en) | 2021-01-28 |
| MX2020013384A (es) | 2021-04-28 |
| CN112654681B (zh) | 2023-01-06 |
| CN112654681A (zh) | 2021-04-13 |
| JP2022522553A (ja) | 2022-04-20 |
| ZA202007842B (en) | 2023-04-26 |
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