IL276860A - Novel adeno-associated virus (AAV) vectors, AAV vectors with reduced capsid deamidation and uses thereof - Google Patents
Novel adeno-associated virus (AAV) vectors, AAV vectors with reduced capsid deamidation and uses thereofInfo
- Publication number
- IL276860A IL276860A IL276860A IL27686020A IL276860A IL 276860 A IL276860 A IL 276860A IL 276860 A IL276860 A IL 276860A IL 27686020 A IL27686020 A IL 27686020A IL 276860 A IL276860 A IL 276860A
- Authority
- IL
- Israel
- Prior art keywords
- aav
- vectors
- associated virus
- uses therefor
- novel adeno
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862635964P | 2018-02-27 | 2018-02-27 | |
| US201862635968P | 2018-02-27 | 2018-02-27 | |
| US201862663788P | 2018-04-27 | 2018-04-27 | |
| US201862663797P | 2018-04-27 | 2018-04-27 | |
| US201862667587P | 2018-05-06 | 2018-05-06 | |
| US201862667881P | 2018-05-07 | 2018-05-07 | |
| US201862667888P | 2018-05-07 | 2018-05-07 | |
| US201862677474P | 2018-05-29 | 2018-05-29 | |
| US201862677471P | 2018-05-29 | 2018-05-29 | |
| US201862667585P | 2018-05-29 | 2018-05-29 | |
| US201862703673P | 2018-07-26 | 2018-07-26 | |
| US201862703670P | 2018-07-26 | 2018-07-26 | |
| US201862722382P | 2018-08-24 | 2018-08-24 | |
| US201862722388P | 2018-08-24 | 2018-08-24 | |
| PCT/US2019/019861 WO2019169004A1 (en) | 2018-02-27 | 2019-02-27 | Novel adeno-associated virus (aav) vectors, aav vectors having reduced capsid deamidation and uses therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL276860A true IL276860A (en) | 2020-10-29 |
Family
ID=67809202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL276860A IL276860A (en) | 2018-02-27 | 2020-08-23 | Novel adeno-associated virus (AAV) vectors, AAV vectors with reduced capsid deamidation and uses thereof |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US12416016B2 (https=) |
| EP (1) | EP3768695A4 (https=) |
| JP (2) | JP7498665B2 (https=) |
| KR (1) | KR102848518B1 (https=) |
| CN (2) | CN120519403A (https=) |
| AU (1) | AU2019228504B2 (https=) |
| BR (1) | BR112020017278A2 (https=) |
| CA (1) | CA3091795A1 (https=) |
| CL (1) | CL2020002201A1 (https=) |
| IL (1) | IL276860A (https=) |
| MA (1) | MA52087A (https=) |
| MX (1) | MX2020008932A (https=) |
| SG (1) | SG11202007942YA (https=) |
| WO (1) | WO2019169004A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018003665A2 (en) | 2015-09-28 | 2018-09-25 | The University Of North Carolina At Chapel Hill | methods and compositions for antibody evasion viral vectors |
| MX2020008932A (es) * | 2018-02-27 | 2020-10-01 | Univ Pennsylvania | Novedosos vectores de virus adenoasociado (aav), vectores de aav que tienen una desamidacion reducida de la capside y usos de estos. |
| US20210363191A1 (en) | 2018-04-03 | 2021-11-25 | Stridebio, Inc. | Antibody-evading virus vectors |
| CN112543766A (zh) | 2018-04-03 | 2021-03-23 | 斯特里迪比奥公司 | 抗体逃避性病毒载体 |
| EP3884057A4 (en) * | 2018-12-21 | 2022-09-07 | The University of North Carolina at Chapel Hill | OPTIMIZED GALC GENES AND EXPRESSION CASSETTE AND THEIR USE |
| BR112021018776A2 (pt) | 2019-03-21 | 2021-11-30 | Stridebio Inc | Vetores de vírus adenoassociado recombinante |
| PE20220014A1 (es) | 2019-04-29 | 2022-01-11 | Univ Pennsylvania | Nuevas capsides de aav y composiciones que las contienen |
| KR20220083714A (ko) | 2019-10-17 | 2022-06-20 | 스트라이드바이오 인코포레이티드 | 니만-피크 질환 c형의 치료를 위한 아데노-연관 바이러스 벡터 |
| CA3155016A1 (en) * | 2019-10-21 | 2021-04-29 | James M. Wilson | Aav3b variants with improved production yield and liver tropism |
| CA3165911A1 (en) * | 2020-01-03 | 2021-07-08 | Sarepta Therapeutics, Inc. | Methods for analyzing aav capsid proteins |
| WO2021183433A1 (en) * | 2020-03-09 | 2021-09-16 | University Of Massachusetts | Gene replacement therapy for foxg1 syndrome |
| IL297391A (en) | 2020-04-20 | 2022-12-01 | Tenaya Therapeutics Inc | An adeno-associated virus with an engineered capsid |
| WO2021222238A1 (en) * | 2020-04-27 | 2021-11-04 | The Trustees Of The University Of Pennsylvania | Compositions and methods for reducing nuclease expression and off-target activity using a promoter with low transcriptional activity |
| US20230220069A1 (en) | 2020-06-17 | 2023-07-13 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of gene therapy patients |
| IL299762A (en) | 2020-07-13 | 2023-03-01 | Univ Pennsylvania | Useful preparations for the treatment of Charcot-Marietot disease |
| EP4200408A1 (en) | 2020-08-19 | 2023-06-28 | Sarepta Therapeutics, Inc. | Adeno-associated virus vectors for treatment of rett syndrome |
| IL302127A (en) | 2020-10-18 | 2023-06-01 | Univ Pennsylvania | An improved adeno-associated virus (AAV) vector and its uses |
| WO2022165313A1 (en) | 2021-02-01 | 2022-08-04 | Regenxbio Inc. | Gene therapy for neuronal ceroid lipofuscinoses |
| KR20230170022A (ko) | 2021-04-12 | 2023-12-18 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 척수 및 연수 근위축증(sbma) 치료에 유용한 조성물 |
| WO2023081807A1 (en) * | 2021-11-04 | 2023-05-11 | The Trustees of the University of Pennsylvania Penn Center for Innovation | Compositions and methods for reducing pcsk9 levels in a subject |
| US20250177495A1 (en) | 2022-01-10 | 2025-06-05 | The Trustees Of The University Of Pennsylvania | Compositions useful in treatment of metachromatic leukodystrophy |
| AR128239A1 (es) | 2022-01-10 | 2024-04-10 | Univ Pennsylvania | Composiciones y métodos útiles para el tratamiento de trastornos mediados por c9orf72 |
| US20250250326A1 (en) | 2022-04-06 | 2025-08-07 | The Trustees Of The University Of Pennsylvania | Passive immunization with anti-aav neutralizing antibodies to prevent off-target transduction of intrathecally delivered aav vectors |
| AU2024245299A1 (en) * | 2023-03-25 | 2025-09-25 | Duke University | Compositions comprising kidney-tropic aavs and methods of use thereof |
| WO2025250683A1 (en) * | 2024-05-29 | 2025-12-04 | Tenaya Therapeutics, Inc. | Adeno-associated virus with engineered capsid |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
| US6268213B1 (en) | 1992-06-03 | 2001-07-31 | Richard Jude Samulski | Adeno-associated virus vector and cis-acting regulatory and promoter elements capable of expressing at least one gene and method of using same for gene therapy |
| US5869305A (en) | 1992-12-04 | 1999-02-09 | The University Of Pittsburgh | Recombinant viral vector system |
| US6204059B1 (en) | 1994-06-30 | 2001-03-20 | University Of Pittsburgh | AAV capsid vehicles for molecular transfer |
| US6093570A (en) | 1995-06-07 | 2000-07-25 | The University Of North Carolina At Chapel Hill | Helper virus-free AAV production |
| WO1998046728A1 (en) | 1997-04-14 | 1998-10-22 | Cell Genesys, Inc. | Methods for increasing the efficiency of recombinant aav product |
| WO1999061643A1 (en) | 1998-05-27 | 1999-12-02 | University Of Florida | Method of preparing recombinant adeno-associated virus compositions by using an iodixananol gradient |
| US6200560B1 (en) | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
| US6221349B1 (en) | 1998-10-20 | 2001-04-24 | Avigen, Inc. | Adeno-associated vectors for expression of factor VIII by target cells |
| ES2340230T3 (es) | 1998-11-10 | 2010-05-31 | University Of North Carolina At Chapel Hill | Vectores viricos y sus procedimientos de preparacion y administracion. |
| PT1916258E (pt) | 1999-08-09 | 2014-07-29 | Genzyme Corp | Aumento da expressão de uma sequência nucleotídica heteróloga de cadeia simples a partir de vectores virais recombinantes por concepção da sequência de maneira que esta forme pares de bases intracadeia |
| US7201898B2 (en) | 2000-06-01 | 2007-04-10 | The University Of North Carolina At Chapel Hill | Methods and compounds for controlled release of recombinant parvovirus vectors |
| NZ532635A (en) | 2001-11-13 | 2007-05-31 | Univ Pennsylvania | A method of identifying unknown adeno-associated virus (AAV) sequences and a kit for the method |
| AU2003274397A1 (en) | 2002-06-05 | 2003-12-22 | University Of Florida | Production of pseudotyped recombinant aav virions |
| WO2004083441A2 (en) * | 2003-03-19 | 2004-09-30 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Random peptide library displayed on aav vectors |
| EP1660970A4 (en) | 2003-08-01 | 2007-02-14 | Dna Twopointo Inc | SYSTEMS AND METHODS FOR BIOPOLYMER TECHNOLOGY |
| US8005620B2 (en) | 2003-08-01 | 2011-08-23 | Dna Twopointo Inc. | Systems and methods for biopolymer engineering |
| CN1856576B (zh) * | 2003-09-30 | 2011-05-04 | 宾夕法尼亚州立大学托管会 | 腺伴随病毒(aav)进化支、序列、含有这些序列的载体及它们的应用 |
| US20060246079A1 (en) | 2003-11-14 | 2006-11-02 | Morrow Phillip R | Neutralizing human antibodies to anthrax toxin |
| WO2006110689A2 (en) | 2005-04-07 | 2006-10-19 | The Trustees Of The University Of Pennsylvania | Method of increasing the function of an aav vector |
| EP1777906A1 (en) | 2005-06-09 | 2007-04-25 | Matsushita Electric Industrial Co., Ltd. | Amplitude error compensating apparatus and orthogonality error compensating apparatus |
| US7588772B2 (en) | 2006-03-30 | 2009-09-15 | Board Of Trustees Of The Leland Stamford Junior University | AAV capsid library and AAV capsid proteins |
| US20130023033A1 (en) | 2010-03-29 | 2013-01-24 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
| US8628966B2 (en) | 2010-04-30 | 2014-01-14 | City Of Hope | CD34-derived recombinant adeno-associated vectors for stem cell transduction and systemic therapeutic gene transfer |
| BR112017005892A2 (pt) * | 2014-09-24 | 2017-12-12 | Hope City | variantes de vetor de vírus adeno-associado para edição de genoma de alta eficácia e métodos da mesma |
| CA2969145A1 (en) * | 2014-11-26 | 2016-06-02 | The Regents Of The University Of California | Therapeutic compositions comprising transcription factors and methods of making and using the same |
| HK1257801A1 (zh) | 2015-10-28 | 2019-11-01 | 宾夕法尼亚州大学信托人 | 用於基因治疗的腺伴随病毒载体的鞘内给药 |
| US11015173B2 (en) | 2015-12-11 | 2021-05-25 | The Trustees Of The University Of Pennsylvania | Scalable purification method for AAV1 |
| WO2017100676A1 (en) | 2015-12-11 | 2017-06-15 | The Trustees Of The University Of Pennsylvania | Scalable purification method for aav8 |
| EP3387138B1 (en) | 2015-12-11 | 2022-01-26 | The Trustees Of The University Of Pennsylvania | Scalable purification method for aav9 |
| WO2017180854A1 (en) * | 2016-04-15 | 2017-10-19 | The Trustees Of The University Of Pennsylvania | Novel aav8 mutant capsids and compositions containing same |
| IL305449B2 (en) | 2016-04-15 | 2026-01-01 | Univ Pennsylvania | Gene therapy for the treatment of mucocutaneous type ii diabetes |
| PE20190401A1 (es) * | 2016-07-26 | 2019-03-13 | Biomarin Pharm Inc | Novedosas proteinas de la capside del virus adenoasociado |
| NZ791267A (en) * | 2016-08-15 | 2025-11-28 | Genzyme Corp | Methods for detecting AAV |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| JP7455579B2 (ja) | 2017-02-28 | 2024-03-26 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 新規アデノ随伴ウイルス（ａａｖ）クレードｆベクター及びその用途 |
| MX2020008932A (es) * | 2018-02-27 | 2020-10-01 | Univ Pennsylvania | Novedosos vectores de virus adenoasociado (aav), vectores de aav que tienen una desamidacion reducida de la capside y usos de estos. |
-
2019
- 2019-02-27 MX MX2020008932A patent/MX2020008932A/es unknown
- 2019-02-27 CA CA3091795A patent/CA3091795A1/en active Pending
- 2019-02-27 JP JP2020545159A patent/JP7498665B2/ja active Active
- 2019-02-27 MA MA052087A patent/MA52087A/fr unknown
- 2019-02-27 SG SG11202007942YA patent/SG11202007942YA/en unknown
- 2019-02-27 BR BR112020017278-2A patent/BR112020017278A2/pt unknown
- 2019-02-27 US US16/975,545 patent/US12416016B2/en active Active
- 2019-02-27 CN CN202510015875.7A patent/CN120519403A/zh active Pending
- 2019-02-27 CN CN201980029022.1A patent/CN112236443B/zh active Active
- 2019-02-27 KR KR1020207027462A patent/KR102848518B1/ko active Active
- 2019-02-27 WO PCT/US2019/019861 patent/WO2019169004A1/en not_active Ceased
- 2019-02-27 EP EP19760152.9A patent/EP3768695A4/en active Pending
- 2019-02-27 AU AU2019228504A patent/AU2019228504B2/en active Active
-
2020
- 2020-08-23 IL IL276860A patent/IL276860A/en unknown
- 2020-08-26 CL CL2020002201A patent/CL2020002201A1/es unknown
-
2024
- 2024-05-31 JP JP2024088641A patent/JP2024115558A/ja active Pending
-
2025
- 2025-08-12 US US19/297,827 patent/US20260049334A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3768695A4 (en) | 2022-04-06 |
| CA3091795A1 (en) | 2019-09-06 |
| KR102848518B1 (ko) | 2025-08-22 |
| JP2021515548A (ja) | 2021-06-24 |
| SG11202007942YA (en) | 2020-09-29 |
| WO2019169004A1 (en) | 2019-09-06 |
| AU2019228504B2 (en) | 2025-06-26 |
| MA52087A (fr) | 2021-06-02 |
| US12416016B2 (en) | 2025-09-16 |
| EP3768695A1 (en) | 2021-01-27 |
| KR20210006327A (ko) | 2021-01-18 |
| AU2019228504A1 (en) | 2020-09-10 |
| MX2020008932A (es) | 2020-10-01 |
| CN112236443A (zh) | 2021-01-15 |
| BR112020017278A2 (pt) | 2020-12-22 |
| US20260049334A1 (en) | 2026-02-19 |
| JP7498665B2 (ja) | 2024-06-12 |
| CN120519403A (zh) | 2025-08-22 |
| JP2024115558A (ja) | 2024-08-26 |
| CL2020002201A1 (es) | 2020-12-18 |
| WO2019169004A9 (en) | 2019-10-31 |
| WO2019169004A8 (en) | 2019-12-05 |
| CN112236443B (zh) | 2025-02-07 |
| US20210123073A1 (en) | 2021-04-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL276859A (en) | Novel adeno-associated virus (AAV) vectors, AAV vectors with reduced capsid deamidation and uses thereof | |
| IL276860A (en) | Novel adeno-associated virus (AAV) vectors, AAV vectors with reduced capsid deamidation and uses thereof | |
| IL286464A (en) | A virus of vectors related to recombinant DNA | |
| IL286911A (en) | Recombinant adeno-associated viruses and their uses | |
| IL286831A (en) | An adeno-associated virus with an engineered capsid | |
| ZA201905407B (en) | Adeno-associated virus (aav) clade f vector and uses therefor | |
| IL286725A (en) | Transgenic adeno-associated vectors for transgene expression | |
| IL263801A (en) | Novel adeno-associated virus capsid proteins | |
| IL287214A (en) | Adeno-associated virus vector formulations and methods | |
| IL304688A (en) | Production of adeno-associated virus (aav). | |
| EP3575398A4 (en) | ADENO-ASSOCIATED VIRUS (AAV) CAPSIDE PROTEIN MUTANT | |
| EP4303225A3 (en) | Polyploid adeno-associated virus vectors and methods of making and using the same | |
| AU2019265855B2 (en) | Adeno-associated virus (AAV) delivery of anti-FAM19A5 antibodies | |
| ES3063368T3 (en) | Lactam-modified adeno-associated virus vectors | |
| SG11201704919SA (en) | Methods of purifying adeno-associated virus (aav) and/or recombinant adeno-associated virus (raav) | |
| HK40130495A (zh) | 新颖腺相关病毒(aav)载体、具有降低的衣壳脱酰胺化的aav载体及其用途 | |
| HK40044078A (en) | Novel adeno-associated virus (aav) vectors, aav vectors having reduced capsid deamidation and uses therefor | |
| HK40044076A (en) | Novel adeno-associated virus (aav) vectors, aav vectors having reduced capsid deamidation and uses therefor | |
| SG11202006169PA (en) | Adeno-associated virus (aav) vector having hybrid hgf gene introduced thereto | |
| HK40066119A (en) | Recombinant adeno-associated virus vectors | |
| HK40072859A (en) | Engineered adeno-associated virus capsids | |
| AU2019902377A0 (en) | AAV capsid polypeptides and AAV vectors | |
| HK40061100A (en) | Aav viral vectors and uses thereof | |
| AU2020904687A0 (en) | Adeno-associated virus capsids and vectors | |
| HK40059043A (en) | Recombinant adeno-associated viruses and uses thereof |