CN112236443B - 新颖腺相关病毒(aav)载体、具有降低的衣壳脱酰胺化的aav载体及其用途 - Google Patents

新颖腺相关病毒(aav)载体、具有降低的衣壳脱酰胺化的aav载体及其用途 Download PDF

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CN112236443B
CN112236443B CN201980029022.1A CN201980029022A CN112236443B CN 112236443 B CN112236443 B CN 112236443B CN 201980029022 A CN201980029022 A CN 201980029022A CN 112236443 B CN112236443 B CN 112236443B
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CN112236443A (zh
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J·M·威尔逊
A·特普
K·特纳
J·J·辛斯
Q·王
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University of Pennsylvania Penn
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/14011—Parvoviridae
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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CN201980029022.1A 2018-02-27 2019-02-27 新颖腺相关病毒(aav)载体、具有降低的衣壳脱酰胺化的aav载体及其用途 Active CN112236443B (zh)

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US201862635964P 2018-02-27 2018-02-27
US201862635968P 2018-02-27 2018-02-27
US62/635968 2018-02-27
US62/635964 2018-02-27
US201862663797P 2018-04-27 2018-04-27
US201862663788P 2018-04-27 2018-04-27
US62/663797 2018-04-27
US62/663788 2018-04-27
US201862667587P 2018-05-06 2018-05-06
US62/667587 2018-05-06
US201862667888P 2018-05-07 2018-05-07
US201862667881P 2018-05-07 2018-05-07
US62/667881 2018-05-07
US62/667888 2018-05-07
US201862667585P 2018-05-29 2018-05-29
US201862677474P 2018-05-29 2018-05-29
US201862677471P 2018-05-29 2018-05-29
US62/667585 2018-05-29
US62/677471 2018-05-29
US62/677474 2018-05-29
US201862703670P 2018-07-26 2018-07-26
US201862703673P 2018-07-26 2018-07-26
US62/703670 2018-07-26
US62/703673 2018-07-26
US201862722382P 2018-08-24 2018-08-24
US201862722388P 2018-08-24 2018-08-24
US62/722382 2018-08-24
US62/722388 2018-08-24
PCT/US2019/019861 WO2019169004A1 (en) 2018-02-27 2019-02-27 Novel adeno-associated virus (aav) vectors, aav vectors having reduced capsid deamidation and uses therefor

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CN202510015875.7A Pending CN120519403A (zh) 2018-02-27 2019-02-27 新颖腺相关病毒(aav)载体、具有降低的衣壳脱酰胺化的aav载体及其用途

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US (2) US12416016B2 (https=)
EP (1) EP3768695A4 (https=)
JP (2) JP7498665B2 (https=)
KR (1) KR102848518B1 (https=)
CN (2) CN112236443B (https=)
AU (1) AU2019228504B2 (https=)
BR (1) BR112020017278A2 (https=)
CA (1) CA3091795A1 (https=)
CL (1) CL2020002201A1 (https=)
IL (1) IL276860A (https=)
MA (1) MA52087A (https=)
MX (1) MX2020008932A (https=)
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CN112236443A (zh) 2021-01-15
JP7498665B2 (ja) 2024-06-12
BR112020017278A2 (pt) 2020-12-22
MA52087A (fr) 2021-06-02
EP3768695A1 (en) 2021-01-27
WO2019169004A1 (en) 2019-09-06
JP2021515548A (ja) 2021-06-24
EP3768695A4 (en) 2022-04-06
AU2019228504A1 (en) 2020-09-10
KR20210006327A (ko) 2021-01-18
WO2019169004A8 (en) 2019-12-05
JP2024115558A (ja) 2024-08-26
CA3091795A1 (en) 2019-09-06
AU2019228504B2 (en) 2025-06-26
US20210123073A1 (en) 2021-04-29
IL276860A (en) 2020-10-29
SG11202007942YA (en) 2020-09-29
US12416016B2 (en) 2025-09-16
MX2020008932A (es) 2020-10-01
KR102848518B1 (ko) 2025-08-22
CN120519403A (zh) 2025-08-22
CL2020002201A1 (es) 2020-12-18
US20260049334A1 (en) 2026-02-19
WO2019169004A9 (en) 2019-10-31

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