IL276010A - Methods for purifying cannabinoids using liquid:liquid chromatography - Google Patents

Methods for purifying cannabinoids using liquid:liquid chromatography

Info

Publication number
IL276010A
IL276010A IL276010A IL27601020A IL276010A IL 276010 A IL276010 A IL 276010A IL 276010 A IL276010 A IL 276010A IL 27601020 A IL27601020 A IL 27601020A IL 276010 A IL276010 A IL 276010A
Authority
IL
Israel
Prior art keywords
liquid
methods
purifying cannabinoids
liquid chromatography
chromatography
Prior art date
Application number
IL276010A
Other languages
English (en)
Hebrew (he)
Inventor
Roura Xavier Nadal
Original Assignee
Phytoplant Res S L
Roura Xavier Nadal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/882,516 external-priority patent/US10207198B2/en
Application filed by Phytoplant Res S L, Roura Xavier Nadal filed Critical Phytoplant Res S L
Publication of IL276010A publication Critical patent/IL276010A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/004Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by obtaining phenols from plant material or from animal material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/02Solvent extraction of solids
    • B01D11/0203Solvent extraction of solids with a supercritical fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/02Solvent extraction of solids
    • B01D11/0288Applications, solvents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/04Solvent extraction of solutions which are liquid
    • B01D11/0492Applications, solvents used
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/10Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1892Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns the sorbent material moving as a whole, e.g. continuous annular chromatography, true moving beds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D9/0004Crystallisation cooling by heat exchange
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/18Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring
    • C07C39/19Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring containing carbon-to-carbon double bonds but no carbon-to-carbon triple bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42Separation; Purification; Stabilisation; Use of additives
    • C07C51/48Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/19Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Analytical Chemistry (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL276010A 2018-01-29 2020-07-13 Methods for purifying cannabinoids using liquid:liquid chromatography IL276010A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15/882,516 US10207198B2 (en) 2015-01-22 2018-01-29 Methods of purifying cannabinoids using liquid:liquid chromatography
PCT/EP2019/052069 WO2019145552A1 (fr) 2018-01-29 2019-01-29 Procédés de purification de cannabinoïdes par chromatographie liquide : liquide

Publications (1)

Publication Number Publication Date
IL276010A true IL276010A (en) 2020-08-31

Family

ID=65276144

Family Applications (1)

Application Number Title Priority Date Filing Date
IL276010A IL276010A (en) 2018-01-29 2020-07-13 Methods for purifying cannabinoids using liquid:liquid chromatography

Country Status (9)

Country Link
EP (1) EP3746419A1 (fr)
CN (1) CN111788171A (fr)
AU (1) AU2019211188A1 (fr)
CA (1) CA3089490A1 (fr)
CL (1) CL2020001964A1 (fr)
CO (1) CO2020009747A2 (fr)
IL (1) IL276010A (fr)
MX (1) MX2020007960A (fr)
WO (1) WO2019145552A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220242810A1 (en) * 2019-06-14 2022-08-04 Purisys Llc Crystalline cannabigerol
CN110590511B (zh) * 2019-09-11 2021-05-28 上海同田生物技术股份有限公司 一种同时分离次大麻二酚和大麻萜酚的方法
CN112279752B (zh) * 2020-10-30 2022-11-11 云南芙雅生物科技有限公司 用于工业大麻的大麻素二氧化碳超临界提取方法
CN113135885A (zh) * 2021-04-07 2021-07-20 上海同田生物技术有限公司 一种高速逆流色谱分离纯化四氢次大麻酚的方法
AU2022376837A1 (en) 2021-10-26 2024-05-23 Ecofibre USA Inc. Systems and methods for producing hemp extracts and compositions
KR20240116463A (ko) 2021-10-26 2024-07-29 더 유니버시티 오브 뉴캐슬 대마 추출물을 이용한 자궁내막증 및 기타 비암성 부인과 장애의 치료 방법
MX2024004994A (es) 2021-10-26 2024-06-21 Univ Newcastle Métodos para tratar el cáncer de ovário con extracto de cáñamo.
CN115385780B (zh) * 2022-08-26 2024-02-27 晨光生物科技集团股份有限公司 一种次大麻二酚结晶多晶型物及其制备方法和应用
WO2024091987A1 (fr) 2022-10-26 2024-05-02 Ecofibre USA Inc. Méthodes de traitement de maladies sensibles aux œstrogènes avec extrait de cannabis
WO2024091989A1 (fr) 2022-10-26 2024-05-02 Ecofibre USA Inc. Compositions stabilisées comprenant du cannabidiol
FR3146813A1 (fr) 2023-03-24 2024-09-27 Gilson Purification Procédés de séparation et de purification d'un composé organique contenu dans une matière d'origine naturelle

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035296A1 (fr) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Liberation amelioree d'agents medicamenteux actifs par un enrobage de chewing-gum
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
EP1474412B1 (fr) * 2002-02-01 2008-05-28 Resolution Chemicals Limited Production de delta-9 tetrahydrocannabinol
US20080103193A1 (en) * 2006-10-26 2008-05-01 Trevor Percival Castor Methods for making compositions and compositions for treating pain and cachexia
UY36530A (es) 2015-01-22 2016-08-31 Phytoplant Res S L Métodos para purificar cannabinoides, composiciones y kits de estos
US10155708B2 (en) * 2015-01-22 2018-12-18 Phytoplant Research S.L. Methods of purifying cannabinoids, compositions and kits thereof
EP3061510A1 (fr) 2015-02-27 2016-08-31 Bionorica Ethics GmbH Chromatographie de partition cpc de cannabinoïdes
BG112018A (bg) * 2015-05-22 2016-11-30 "Побелч-Гле" Оод Метод за получаване на канабиноиден извлек от коноп

Also Published As

Publication number Publication date
CA3089490A1 (fr) 2019-08-01
WO2019145552A1 (fr) 2019-08-01
CN111788171A (zh) 2020-10-16
CL2020001964A1 (es) 2020-12-18
EP3746419A1 (fr) 2020-12-09
CO2020009747A2 (es) 2020-08-21
MX2020007960A (es) 2020-09-24
AU2019211188A1 (en) 2020-07-30

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