IL270828B2 - 6-5 fused ring as c5a inhibitors - Google Patents

Info

Publication number

IL270828B2

IL270828B2 IL270828A IL27082819A IL270828B2 IL 270828 B2 IL270828 B2 IL 270828B2 IL 270828 A IL270828 A IL 270828A IL 27082819 A IL27082819 A IL 27082819A IL 270828 B2 IL270828 B2 IL 270828B2

Authority

IL

Israel

Prior art keywords

alkyl

mmol

compound

group

pharmaceutically acceptable

Prior art date

2017-05-31

Links

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• 239000000203 mixture Substances 0.000 claims description 174
• 150000001875 compounds Chemical class 0.000 claims description 159
• -1 cyano, hydroxyl Chemical group 0.000 claims description 61
• 150000003839 salts Chemical class 0.000 claims description 59
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• 229910052757 nitrogen Inorganic materials 0.000 claims description 39
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• 125000005842 heteroatom Chemical group 0.000 claims description 31
• 229910052760 oxygen Inorganic materials 0.000 claims description 27
• 229910052736 halogen Inorganic materials 0.000 claims description 26
• 150000002367 halogens Chemical class 0.000 claims description 26
• 125000001424 substituent group Chemical group 0.000 claims description 25
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 24
• 238000000034 method Methods 0.000 claims description 24
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• 229910052717 sulfur Inorganic materials 0.000 claims description 23
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• 229910052739 hydrogen Inorganic materials 0.000 claims description 19
• 239000001257 hydrogen Substances 0.000 claims description 19
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 17
• 239000008194 pharmaceutical composition Substances 0.000 claims description 17
• 229940124597 therapeutic agent Drugs 0.000 claims description 15
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