IL270070B2 - Compounds, compositions and methods for treating or preventing acute lung injury - Google Patents
Compounds, compositions and methods for treating or preventing acute lung injuryInfo
- Publication number
- IL270070B2 IL270070B2 IL270070A IL27007019A IL270070B2 IL 270070 B2 IL270070 B2 IL 270070B2 IL 270070 A IL270070 A IL 270070A IL 27007019 A IL27007019 A IL 27007019A IL 270070 B2 IL270070 B2 IL 270070B2
- Authority
- IL
- Israel
- Prior art keywords
- pazopanib
- subject
- solvate
- salt
- day
- Prior art date
Links
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- 150000003751 zinc Chemical class 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
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- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Public Health (AREA)
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- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Otolaryngology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US201762486232P | 2017-04-17 | 2017-04-17 | |
| PCT/US2018/027980 WO2018195084A1 (en) | 2017-04-17 | 2018-04-17 | Compounds, compositions and methods of treating or preventing acute lung injury |
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| IL270070A IL270070A (enExample) | 2019-12-31 |
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| IL270070A IL270070B2 (en) | 2017-04-17 | 2018-04-17 | Compounds, compositions and methods for treating or preventing acute lung injury |
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| WO (1) | WO2018195084A1 (enExample) |
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| AU2020386436A1 (en) * | 2019-11-20 | 2022-05-26 | Yale University | Compounds, compositions, and methods for treating ischemia-reperfusion injury and/or lung injury |
| CN113350351A (zh) * | 2020-03-13 | 2021-09-07 | 青晓制药公司 | 帕唑帕尼的应用、药物组合物、注射液及制备方法和应用 |
| US20230181582A1 (en) * | 2020-05-22 | 2023-06-15 | Qx Therapeutics Inc. | Compositions and methods for treating lung injuries associated with viral infections |
| CN113624978B (zh) * | 2021-04-06 | 2023-09-19 | 四川大学华西医院 | 通过检测肺泡灌洗液及血清白蛋白来评估急性呼吸窘迫综合征/急性肺损伤及预后的试剂盒 |
Citations (3)
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| US20110142837A1 (en) * | 2007-07-20 | 2011-06-16 | Trustees Of The University Of Pennsylvania | Method Of Treating Acute Respiratory Distress Syndrome |
| US20130289014A1 (en) * | 2010-04-27 | 2013-10-31 | Boehringer Ingelheim International Gmbh | Combination therapy in treatment of oncological and fibrotic diseases |
| US20160208002A1 (en) * | 2013-09-30 | 2016-07-21 | Richard H. Gomer | Compositions Associated with and Methods of Managing Neutrophil Movement |
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| US5007790A (en) | 1989-04-11 | 1991-04-16 | Depomed Systems, Inc. | Sustained-release oral drug dosage form |
| US5582837A (en) | 1992-03-25 | 1996-12-10 | Depomed, Inc. | Alkyl-substituted cellulose-based sustained-release oral drug dosage forms |
| JPH07507059A (ja) | 1992-03-25 | 1995-08-03 | デポムド システムズ，インコーポレイテッド | アルキル置換セルロースをベースとする持続放出性経口薬剤投与剤形 |
| AU3290397A (en) | 1996-06-10 | 1998-01-07 | Depomed, Inc. | Gastric-retentive oral controlled drug delivery system with enhanced retention properties |
| US5972389A (en) | 1996-09-19 | 1999-10-26 | Depomed, Inc. | Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter |
| US6635280B2 (en) | 1997-06-06 | 2003-10-21 | Depomed, Inc. | Extending the duration of drug release within the stomach during the fed mode |
| EP0998271B3 (en) | 1997-06-06 | 2014-10-29 | Depomed, Inc. | Gastric-retentive oral drug dosage forms for controlled release of highly soluble drugs |
| AU781718B2 (en) | 1999-11-02 | 2005-06-09 | Depomed, Inc. | Pharmacological inducement of the fed mode for enhanced drug administration to the stomach |
| ATE340563T1 (de) | 2000-02-04 | 2006-10-15 | Depomed Inc | DOSIERUNGSFORM DES TYPS ßHÜLLE UND KERNß MIT EINER WIRKSTOFFFREISETZUNG, DIE SICH DER NULLTEN ORDNUNG ANNÄHERT |
| US6488962B1 (en) | 2000-06-20 | 2002-12-03 | Depomed, Inc. | Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms |
| US6451808B1 (en) | 2000-10-17 | 2002-09-17 | Depomed, Inc. | Inhibition of emetic effect of metformin with 5-HT3 receptor antagonists |
| EP1343782B1 (en) | 2000-12-21 | 2009-05-06 | SmithKline Beecham Corporation | Pyrimidineamines as angiogenesis modulators |
| EP1401423A4 (en) | 2001-05-29 | 2006-08-16 | Depomed Dev Ltd | METHOD FOR THE TREATMENT OF GASTROÖSOPHAGEAL REFLUX DISEASE AND NURSING ACID BREAKDOWN |
| TWI312285B (en) | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
| US7413751B2 (en) | 2001-10-25 | 2008-08-19 | Depomed, Inc. | Methods of treatment using a gastric retained losartan dosage |
| CA2409552A1 (en) | 2001-10-25 | 2003-04-25 | Depomed, Inc. | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
| US6723340B2 (en) | 2001-10-25 | 2004-04-20 | Depomed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
| US20030091630A1 (en) | 2001-10-25 | 2003-05-15 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data |
| US6682759B2 (en) | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
| WO2008080153A2 (en) * | 2006-12-22 | 2008-07-03 | The Children's Hospital Of Philadelphia | A novel protein kinase c therapy for the treatment of acute lung injury |
| EP2259844A4 (en) | 2008-03-05 | 2012-02-01 | Vicus Therapeutics Llc | COMPOSITIONS AND METHODS FOR MUCOSITIS AND ONCOLOGICAL THERAPIES |
| JP2014503500A (ja) * | 2010-11-18 | 2014-02-13 | シンタ ファーマスーティカルズ コーポレーション | 低酸素状態に基づく酸素感受性薬剤による治療に適した被験体の事前選択 |
| MY181439A (en) * | 2011-02-28 | 2020-12-22 | Sunshine Lake Pharma Co Ltd | Substituted quinoline compounds and methods of use |
| CN104254249B (zh) * | 2011-10-31 | 2017-02-15 | 诺华股份有限公司 | 帕唑帕尼制剂 |
| WO2013148537A1 (en) * | 2012-03-29 | 2013-10-03 | Ning Xi | Substituted spirobicyclic compounds and methods of use |
| US20150044288A1 (en) | 2013-07-31 | 2015-02-12 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
| KR101636563B1 (ko) * | 2014-01-24 | 2016-07-06 | 주식회사 엘지생명과학 | 급성 폐 손상 및 급성 호흡곤란 증후군의 예방 또는 치료용 조성물 |
| US9718841B2 (en) * | 2014-04-22 | 2017-08-01 | Calitor Sciences, Llc | Bicyclic pyrazolone compounds and methods of use |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110142837A1 (en) * | 2007-07-20 | 2011-06-16 | Trustees Of The University Of Pennsylvania | Method Of Treating Acute Respiratory Distress Syndrome |
| US20130289014A1 (en) * | 2010-04-27 | 2013-10-31 | Boehringer Ingelheim International Gmbh | Combination therapy in treatment of oncological and fibrotic diseases |
| US20160208002A1 (en) * | 2013-09-30 | 2016-07-21 | Richard H. Gomer | Compositions Associated with and Methods of Managing Neutrophil Movement |
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| KAPADIA ET AL,, RISK OF LIVER TOXICITY WITH THE ANGIOGENESIS INHIBITOR PAZOPANIB IN CANCER PATIENTS, 31 December 2013 (2013-12-31) * |
| MCMILLAN ET AL., SIGLEC-E PROMOTES 2-INTEGRIN-DEPENDENT NADPH OXIDASE ACTIVATION TO SUPPRESS NEUTROPHIL RECRUITMENT TO THE LUNG, 31 December 2014 (2014-12-31) * |
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| US11166953B2 (en) | 2021-11-09 |
| WO2018195084A1 (en) | 2018-10-25 |
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| US20210121459A1 (en) | 2021-04-29 |
| IL270070B1 (en) | 2023-05-01 |
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| EP3612184A4 (en) | 2021-01-20 |
| JP7108018B2 (ja) | 2022-07-27 |
| JP2020516689A (ja) | 2020-06-11 |
| CA3060247A1 (en) | 2018-10-25 |
| US20240165115A1 (en) | 2024-05-23 |
| EP3612184A1 (en) | 2020-02-26 |
| IL270070A (enExample) | 2019-12-31 |
| EP3612184B1 (en) | 2024-06-05 |
| US20220040177A1 (en) | 2022-02-10 |
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