IL269856B2 - Coversin variants lack C5 linkers - Google Patents
Coversin variants lack C5 linkersInfo
- Publication number
- IL269856B2 IL269856B2 IL269856A IL26985619A IL269856B2 IL 269856 B2 IL269856 B2 IL 269856B2 IL 269856 A IL269856 A IL 269856A IL 26985619 A IL26985619 A IL 26985619A IL 269856 B2 IL269856 B2 IL 269856B2
- Authority
- IL
- Israel
- Prior art keywords
- seq
- replaced
- coversin
- modified
- modified coversin
- Prior art date
Links
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- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
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Applications Claiming Priority (2)
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| GBGB1706406.4A GB201706406D0 (en) | 2017-04-21 | 2017-04-21 | Method of treatment |
| PCT/EP2018/060240 WO2018193121A1 (en) | 2017-04-21 | 2018-04-20 | Coversin variants lacking c5 binding |
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| IL269856A IL269856A (en) | 2019-11-28 |
| IL269856B1 IL269856B1 (en) | 2024-05-01 |
| IL269856B2 true IL269856B2 (en) | 2024-09-01 |
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| IL269856A IL269856B2 (en) | 2017-04-21 | 2018-04-20 | Coversin variants lack C5 linkers |
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| EP (1) | EP3612207B1 (enExample) |
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| KR (1) | KR102630702B1 (enExample) |
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| IL (1) | IL269856B2 (enExample) |
| PL (1) | PL3612207T3 (enExample) |
| WO (1) | WO2018193121A1 (enExample) |
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| CN110831617A (zh) * | 2017-04-21 | 2020-02-21 | 沃卢申伊缪诺制药公司 | 用于治疗瘢痕性眼部发炎性病症的Coversin |
| GB201706406D0 (en) | 2017-04-21 | 2017-06-07 | Volution Immuno Pharmaceuticals Sa | Method of treatment |
| JP7209637B2 (ja) | 2017-04-21 | 2023-01-20 | ヴォリューション イミュノ ファーマシューティカルズ エスエイ | 自己免疫性水疱症の治療のためのコバーシン |
| JP7629394B2 (ja) * | 2018-09-10 | 2025-02-13 | ヴォリューション イミュノ ファーマシューティカルズ エスエイ | リウマチ性疾患の治療に使用するためのコバーシン |
| GB201905810D0 (en) * | 2019-04-25 | 2019-06-05 | Volution Immuno Pharmaceuticals Sa | Method of treatment |
| JP2023503776A (ja) | 2019-09-27 | 2023-02-01 | ヴォリューション イミュノ ファーマシューティカルズ エスエイ | 造血幹細胞移植後の血栓性微小血管症（ｈｓｃｔ－ｔｍａ）の治療方法 |
| GB202218084D0 (en) | 2022-12-01 | 2023-01-18 | Volution Immuno Pharmaceuticals Sa | Fusion proteins |
| GB202408081D0 (en) | 2024-06-06 | 2024-07-24 | Volution Immuno Pharmaceuticals Sa | Methods of removing impurities |
Citations (2)
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| WO2009098454A2 (en) * | 2008-02-05 | 2009-08-13 | Natural Environment Research Council | Treatment of diseases and conditions mediated by eicosanoids |
| WO2010100396A1 (en) * | 2009-02-05 | 2010-09-10 | Natural Environment Research Council | Modified omci as a complement inhibitor |
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| US20030077709A1 (en) * | 2000-03-21 | 2003-04-24 | Masazumi Kamohara | Novel leukotriene B4 receptor |
| CA2481231A1 (en) * | 2002-04-05 | 2003-10-23 | University Of Utah Research Foundation | Colon tumor specific binding peptides |
| US7884188B2 (en) | 2003-06-02 | 2011-02-08 | Varleigh Immuno Pharmaceuticals (Vip) Ltd | Complement inhibitors |
| EP1739078A1 (de) | 2005-05-30 | 2007-01-03 | Jerini AG | C5a-Rezeptor-Antagonisten |
| GB0518443D0 (en) * | 2005-09-09 | 2005-10-19 | Evolutec Ltd | Method of treating myasthenia gravis |
| WO2008113834A2 (en) | 2007-03-22 | 2008-09-25 | Novartis Ag | C5 antigens and uses thereof |
| CA2840270C (en) | 2011-06-22 | 2023-09-26 | Apellis Pharmaceuticals, Inc. | Methods of treating chronic disorders with complement inhibitors |
| GB201410031D0 (en) | 2014-06-05 | 2014-07-16 | Isis Innovation | Polypeptides and uses thereof |
| WO2016198133A1 (en) | 2015-06-08 | 2016-12-15 | Volution Immuno Pharmaceuticals Sa | Ornithodoros moubata complement inhibitor for use in the treatment of acute graft versus host disease |
| JP7209637B2 (ja) | 2017-04-21 | 2023-01-20 | ヴォリューション イミュノ ファーマシューティカルズ エスエイ | 自己免疫性水疱症の治療のためのコバーシン |
| GB201706406D0 (en) | 2017-04-21 | 2017-06-07 | Volution Immuno Pharmaceuticals Sa | Method of treatment |
| CN110831617A (zh) | 2017-04-21 | 2020-02-21 | 沃卢申伊缪诺制药公司 | 用于治疗瘢痕性眼部发炎性病症的Coversin |
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2018
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- 2018-04-20 CN CN201880040770.5A patent/CN110799207B/zh active Active
- 2018-04-20 AU AU2018253961A patent/AU2018253961B2/en active Active
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2021
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009098454A2 (en) * | 2008-02-05 | 2009-08-13 | Natural Environment Research Council | Treatment of diseases and conditions mediated by eicosanoids |
| WO2010100396A1 (en) * | 2009-02-05 | 2010-09-10 | Natural Environment Research Council | Modified omci as a complement inhibitor |
Non-Patent Citations (4)
| Title |
|---|
| DATABASE BIOSIS [ONLINE]BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2 DECEMBER 2016 (2016-12-02),MILES NUNN ET AL:, THERAPEUTIC DEVELOPMENT OF COMPLEMENT C5 INHIBITOR COVERSIN (TM) WITH EXTENDED HALF-LIFE VIA PASYLATION (R), 2 December 2016 (2016-12-02) * |
| MANS B J ET AL:, FUNCTION, MECHANISM AND EVOLUTION OF THE MOUBATIN- CLADE OF SOFT TICK LIPOCALINS, 1 September 2008 (2008-09-01) * |
| MATTHIJS M JORE ET AL:, STRUCTURAL BASIS FOR THERAPEUTIC INHIBITION OF COMPLEMENT C5, 28 April 2016 (2016-04-28) * |
| ROVERSI ET AL:, THE STRUCTURE OF OMCI, A NOVEL LIPOCALIN INHIBITOR OF THE COMPLEMENT SYSTEM, 11 May 2007 (2007-05-11) * |
Also Published As
| Publication number | Publication date |
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| CN110799207A (zh) | 2020-02-14 |
| EP3612207C0 (en) | 2024-04-10 |
| PL3612207T3 (pl) | 2024-09-23 |
| GB201706406D0 (en) | 2017-06-07 |
| US11214602B2 (en) | 2022-01-04 |
| EP3612207B1 (en) | 2024-04-10 |
| EP3612207A1 (en) | 2020-02-26 |
| WO2018193121A1 (en) | 2018-10-25 |
| CN110799207B (zh) | 2024-05-03 |
| IL269856A (en) | 2019-11-28 |
| AU2018253961A1 (en) | 2019-10-31 |
| IL269856B1 (en) | 2024-05-01 |
| US20230002456A1 (en) | 2023-01-05 |
| JP2020517260A (ja) | 2020-06-18 |
| KR20190141163A (ko) | 2019-12-23 |
| US20200385434A1 (en) | 2020-12-10 |
| ES2980279T3 (es) | 2024-09-30 |
| JP7183180B2 (ja) | 2022-12-05 |
| KR102630702B1 (ko) | 2024-01-29 |
| CA3060336A1 (en) | 2018-10-25 |
| AU2018253961B2 (en) | 2022-06-02 |
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