IL269607A - Microparticles coated with minerals for prolonged delivery of biologically active molecules - Google Patents
Microparticles coated with minerals for prolonged delivery of biologically active moleculesInfo
- Publication number
- IL269607A IL269607A IL26960719A IL26960719A IL269607A IL 269607 A IL269607 A IL 269607A IL 26960719 A IL26960719 A IL 26960719A IL 26960719 A IL26960719 A IL 26960719A IL 269607 A IL269607 A IL 269607A
- Authority
- IL
- Israel
- Prior art keywords
- biologically active
- active molecules
- sustained delivery
- coated microparticles
- mineral coated
- Prior art date
Links
- 229910052500 inorganic mineral Inorganic materials 0.000 title 1
- 239000011859 microparticle Substances 0.000 title 1
- 239000011707 mineral Substances 0.000 title 1
- 230000002459 sustained effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Ceramic Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762480710P | 2017-04-03 | 2017-04-03 | |
| PCT/US2018/025913 WO2018187344A1 (en) | 2017-04-03 | 2018-04-03 | Mineral coated microparticles for sustained delivery of biologically active molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL269607A true IL269607A (en) | 2019-11-28 |
Family
ID=63712804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL26960719A IL269607A (en) | 2017-04-03 | 2019-09-24 | Microparticles coated with minerals for prolonged delivery of biologically active molecules |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US12465654B2 (enExample) |
| EP (1) | EP3606512A4 (enExample) |
| JP (1) | JP7170031B2 (enExample) |
| KR (1) | KR20190130643A (enExample) |
| CN (2) | CN122351174A (enExample) |
| AU (1) | AU2018249816B2 (enExample) |
| BR (1) | BR112019020373A2 (enExample) |
| CA (1) | CA3058802A1 (enExample) |
| IL (1) | IL269607A (enExample) |
| WO (1) | WO2018187344A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190130643A (ko) | 2017-04-03 | 2019-11-22 | 위스콘신 얼럼나이 리서어치 화운데이션 | 생물학적 활성 분자의 지속적인 전달을 위한 미네랄 코팅된 마이크로입자 |
| WO2022051247A1 (en) * | 2020-09-01 | 2022-03-10 | Dianomi Therapeutics, Inc. | Methods for treating or preventing inflammatory events |
| DE102020129648A1 (de) * | 2020-11-10 | 2022-05-12 | Leopold MTX GmbH | Pharmazeutische zusammensetzung |
| CN114917364A (zh) * | 2022-05-12 | 2022-08-19 | 云南大学附属医院 | 一种携IL-8和Anakinra双配体靶向纳米微泡的制备方法 |
| WO2024102801A2 (en) * | 2022-11-09 | 2024-05-16 | Wisconsin Alumni Research Foundation | Mineral-coated iron oxide microparticles and use of same including use for immunomodulation |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5075222A (en) | 1988-05-27 | 1991-12-24 | Synergen, Inc. | Interleukin-1 inhibitors |
| TWI267378B (en) * | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| JP2003212756A (ja) * | 2002-01-21 | 2003-07-30 | Olympus Optical Co Ltd | 薬剤徐放剤 |
| US7459426B2 (en) * | 2004-06-04 | 2008-12-02 | Regeneron Pharmaceuticals, Inc. | Methods of using IL-1 antagonists to treat autoinflammatory disease |
| US7655758B2 (en) * | 2004-08-17 | 2010-02-02 | Regeneron Pharmaceuticals, Inc. | Stable liquid IL-1 antagonist formulations |
| US7473678B2 (en) | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| MX373000B (es) * | 2005-09-14 | 2020-05-21 | Mannkind Corp | Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas. |
| JPWO2008041704A1 (ja) | 2006-10-02 | 2010-02-04 | 独立行政法人物質・材料研究機構 | 徐放性製剤 |
| WO2010036919A1 (en) * | 2008-09-25 | 2010-04-01 | Tissue Regeneration Systems, Inc. | Mineral-coated microspheres |
| WO2008130529A1 (en) * | 2007-04-16 | 2008-10-30 | University Of Toledo | Hybrid biomimetic particles, methods of making same and uses therefor |
| US8470360B2 (en) | 2008-04-18 | 2013-06-25 | Warsaw Orthopedic, Inc. | Drug depots having different release profiles for reducing, preventing or treating pain and inflammation |
| US20090111763A1 (en) * | 2007-10-26 | 2009-04-30 | Celonova Biosciences, Inc. | Loadable polymeric particles for bone augmentation and methods of preparing and using the same |
| CA2716896C (en) | 2008-02-29 | 2016-08-09 | Smith & Nephew, Inc. | Gradient antimicrobial coating for medical implants |
| US20100015049A1 (en) * | 2008-07-16 | 2010-01-21 | Warsaw Orthopedic, Inc. | Methods and compositions for treating postoperative pain comprising nonsteroidal anti-inflammatory agents |
| US20160017368A1 (en) | 2013-02-19 | 2016-01-21 | Wisconsin Alumni Research Foundation | Inorganic coatings for the enhancement of chemical transfection |
| WO2016141242A1 (en) | 2015-03-03 | 2016-09-09 | Tissue Regeneration Systems, Inc. | Coating scaffolds |
| US10780054B2 (en) | 2015-04-17 | 2020-09-22 | Curevac Real Estate Gmbh | Lyophilization of RNA |
| KR20190130643A (ko) | 2017-04-03 | 2019-11-22 | 위스콘신 얼럼나이 리서어치 화운데이션 | 생물학적 활성 분자의 지속적인 전달을 위한 미네랄 코팅된 마이크로입자 |
| CA3068917A1 (en) | 2017-07-05 | 2019-01-10 | Wisconsin Alumni Research Foundation | Mineral coated microparticles for co-delivery of anti-inflammatory molecules with nucleic acids to improve gene delivery outcomes |
| US11628227B2 (en) | 2017-07-05 | 2023-04-18 | Wisconsin Alumni Research Foundation | Mineral coated microparticles for gene delivery in chronic wound therapy |
| EP3556728A1 (en) | 2018-04-16 | 2019-10-23 | Croda Denmark A/S | Organically modified mineral micro-particles, methods of preparing the same and uses thereof |
| US20190358344A1 (en) | 2018-05-23 | 2019-11-28 | Dianomi Therapeutics, Inc. | Mineral coated microparticles for sustained delivery of steroids |
| US20240325596A1 (en) | 2021-11-09 | 2024-10-03 | Wisconsin Alumni Research Foundation | Mineral-coated substrates for stabilization of rna-based therapeutic compositions |
-
2018
- 2018-04-03 KR KR1020197032235A patent/KR20190130643A/ko not_active Ceased
- 2018-04-03 JP JP2020502549A patent/JP7170031B2/ja active Active
- 2018-04-03 CN CN202610478235.4A patent/CN122351174A/zh active Pending
- 2018-04-03 US US16/500,017 patent/US12465654B2/en active Active
- 2018-04-03 BR BR112019020373-7A patent/BR112019020373A2/pt active Search and Examination
- 2018-04-03 AU AU2018249816A patent/AU2018249816B2/en active Active
- 2018-04-03 CA CA3058802A patent/CA3058802A1/en active Pending
- 2018-04-03 EP EP18780858.9A patent/EP3606512A4/en active Pending
- 2018-04-03 WO PCT/US2018/025913 patent/WO2018187344A1/en not_active Ceased
- 2018-04-03 CN CN201880036493.0A patent/CN110691588A/zh active Pending
-
2019
- 2019-09-24 IL IL26960719A patent/IL269607A/en unknown
-
2025
- 2025-10-15 US US19/359,408 patent/US20260041786A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3606512A1 (en) | 2020-02-12 |
| EP3606512A4 (en) | 2021-01-13 |
| JP7170031B2 (ja) | 2022-11-11 |
| CN110691588A (zh) | 2020-01-14 |
| JP2020513033A (ja) | 2020-04-30 |
| US12465654B2 (en) | 2025-11-11 |
| US20260041786A1 (en) | 2026-02-12 |
| KR20190130643A (ko) | 2019-11-22 |
| CN122351174A (zh) | 2026-07-10 |
| AU2018249816B2 (en) | 2025-04-17 |
| US20200164087A1 (en) | 2020-05-28 |
| WO2018187344A1 (en) | 2018-10-11 |
| BR112019020373A2 (pt) | 2020-04-28 |
| CA3058802A1 (en) | 2018-10-11 |
| AU2018249816A1 (en) | 2019-10-17 |
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