IL268983B1

IL268983B1 - תולדה של חומצת גרעין עם פעילות ממריצת חיסון

תולדה של חומצת גרעין עם פעילות ממריצת חיסון

Info

Publication number: IL268983B1
Authority: IL; Israel
Prior art keywords: seq; mmol; compound; mixture; strand
Prior art date: 2017-03-29

Application number

IL268983A

Other languages

English (en)

Other versions

IL268983B2 (he

IL268983A (he

Original Assignee

Shionogi & Co

Priority date

2017-03-29

Filing date

2017-03-29

Publication date

2024-03-01

2017-03-29 Application filed by Shionogi & Co filed Critical Shionogi & Co

2019-10-31 Publication of IL268983A publication Critical patent/IL268983A/he

2024-03-01 Publication of IL268983B1 publication Critical patent/IL268983B1/he

2024-07-01 Publication of IL268983B2 publication Critical patent/IL268983B2/he

Links

108020004707 nucleic acids Proteins 0.000 title description 27
102000039446 nucleic acids Human genes 0.000 title description 27
150000007523 nucleic acids Chemical class 0.000 title description 27
230000003308 immunostimulating effect Effects 0.000 title description 17
108091034117 Oligonucleotide Proteins 0.000 claims description 222
239000000427 antigen Substances 0.000 claims description 146
108091007433 antigens Proteins 0.000 claims description 137
102000036639 antigens Human genes 0.000 claims description 137
150000002632 lipids Chemical class 0.000 claims description 89
206010028980 Neoplasm Diseases 0.000 claims description 68
150000003833 nucleoside derivatives Chemical class 0.000 claims description 42
239000002777 nucleoside Substances 0.000 claims description 38
239000002773 nucleotide Substances 0.000 claims description 37
125000003729 nucleotide group Chemical group 0.000 claims description 37
239000000126 substance Substances 0.000 claims description 26
239000008194 pharmaceutical composition Substances 0.000 claims description 25
125000001424 substituent group Chemical group 0.000 claims description 22
235000000346 sugar Nutrition 0.000 claims description 22
150000002430 hydrocarbons Chemical group 0.000 claims description 14
125000003835 nucleoside group Chemical group 0.000 claims description 13
230000000813 microbial effect Effects 0.000 claims description 9
239000004215 Carbon black (E152) Substances 0.000 claims description 8
ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 8
229930195733 hydrocarbon Natural products 0.000 claims description 8
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 6
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SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 6
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