IL268415B - Delta-opioid receptor modulator compounds containing 7-atom aza-heterocycles, methods for their use and preparation - Google Patents
Delta-opioid receptor modulator compounds containing 7-atom aza-heterocycles, methods for their use and preparationInfo
- Publication number
- IL268415B IL268415B IL268415A IL26841519A IL268415B IL 268415 B IL268415 B IL 268415B IL 268415 A IL268415 A IL 268415A IL 26841519 A IL26841519 A IL 26841519A IL 268415 B IL268415 B IL 268415B
- Authority
- IL
- Israel
- Prior art keywords
- making
- methods
- same
- opioid receptor
- modulating compounds
- Prior art date
Links
- 101100244562 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) oprD gene Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 108700023159 delta Opioid Receptors Proteins 0.000 title 1
- 102000048124 delta Opioid Receptors Human genes 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762460386P | 2017-02-17 | 2017-02-17 | |
| PCT/US2018/018303 WO2018152286A1 (en) | 2017-02-17 | 2018-02-15 | 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL268415A IL268415A (en) | 2019-09-26 |
| IL268415B true IL268415B (en) | 2022-06-01 |
Family
ID=63170722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL268415A IL268415B (en) | 2017-02-17 | 2019-08-01 | Delta-opioid receptor modulator compounds containing 7-atom aza-heterocycles, methods for their use and preparation |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11225487B2 (enExample) |
| EP (1) | EP3582783B1 (enExample) |
| JP (1) | JP7185633B2 (enExample) |
| KR (1) | KR102662065B1 (enExample) |
| CN (1) | CN110446495B (enExample) |
| AU (1) | AU2018221705B2 (enExample) |
| BR (1) | BR112019016775A2 (enExample) |
| CA (1) | CA3052479A1 (enExample) |
| IL (1) | IL268415B (enExample) |
| WO (1) | WO2018152286A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110520129A (zh) | 2017-02-17 | 2019-11-29 | 特维娜有限公司 | 含有5元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
| CN110446495B (zh) | 2017-02-17 | 2023-09-05 | 特维娜有限公司 | 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
| CN116406268A (zh) | 2020-10-27 | 2023-07-07 | 特维娜有限公司 | δ-阿片样物质调节剂的结晶和无定形形式 |
| CN119285615B (zh) * | 2024-09-29 | 2025-09-19 | 广东医科大学 | 一种生物碱类化合物在制备具有抗ⅱ型单纯疱疹病毒作用的药物中的应用 |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE352811B (enExample) | 1971-06-04 | 1973-01-15 | Pharmacia Ab | |
| US3960150A (en) | 1971-09-09 | 1976-06-01 | Alza Corporation | Bioerodible ocular device |
| US3867519A (en) | 1972-04-27 | 1975-02-18 | Alza Corp | Bioerodible drug delivery device |
| SE375007B (enExample) | 1972-11-30 | 1975-04-07 | Pharmacia Ab | |
| US3963025A (en) | 1974-09-16 | 1976-06-15 | Alza Corporation | Ocular drug delivery device |
| JPS5825980B2 (ja) | 1976-02-12 | 1983-05-31 | ヤマサ醤油株式会社 | サイクリックヌクレオチドの定量法 |
| US4209514A (en) * | 1977-06-24 | 1980-06-24 | Ciba-Geigy Corporation | 3-Aminoalkyl-4-aryl-tetrahydroazepines |
| US4186184A (en) | 1977-12-27 | 1980-01-29 | Alza Corporation | Selective administration of drug with ocular therapeutic system |
| US4303637A (en) | 1980-04-04 | 1981-12-01 | Alza Corporation | Medication indicated for ocular hypertension |
| DK231088D0 (da) | 1988-04-28 | 1988-04-28 | Ferrosan As | Piperidinforbindelser, deres fremstilling og anvendelse |
| CA1337418C (en) * | 1988-03-28 | 1995-10-24 | Engelbert Ciganek | 4-aryl-4-piperiding (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof |
| US5086063A (en) * | 1988-03-28 | 1992-02-04 | Du Pont Merck Pharmaceutical Company | 4-aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof |
| US5401629A (en) | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| DE69633527T2 (de) | 1995-12-04 | 2006-02-16 | Tosoh Corp., Shinnanyo | Verfahren zur Herstellung von Benzylalkohol |
| HUP9902160A3 (en) | 1996-03-29 | 2001-02-28 | Pfizer | Benzyl(idene)-lactam derivatives, their use as selective (ant)agonists of 5-ht1a-and/or 5-ht1d receptors, pharmaceutical compositions containing these compounds |
| JP2000513375A (ja) | 1996-06-28 | 2000-10-10 | メルク エンド カンパニー インコーポレーテッド | フィブリノーゲンレセプター拮抗薬プロドラッグ |
| WO1998006694A1 (en) | 1996-08-16 | 1998-02-19 | Du Pont Pharmaceuticals Company | Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof |
| AU4727799A (en) * | 1998-06-30 | 2000-01-17 | Eli Lilly And Company | Azepine derivatives having effects on serotonin related systems |
| TR200102911T2 (tr) | 1999-04-09 | 2002-01-21 | Astrazeneca Ab | Adamantan türevleri. |
| AU1018801A (en) | 1999-10-29 | 2001-05-14 | Novo Nordisk A/S | Use of 3,4-substituted piperidines |
| GB0015562D0 (en) | 2000-06-23 | 2000-08-16 | Pfizer Ltd | Heterocycles |
| AU2001273040A1 (en) | 2000-06-27 | 2002-01-08 | Du Pont Pharmaceuticals Company | Factor xa inhibitors |
| US20020077323A1 (en) | 2000-07-12 | 2002-06-20 | Mclean Stafford | Use of delta opioid receptor ligands and serotonin reuptake inhibitors in the treatment of chemical dependencies |
| US6476046B1 (en) | 2000-12-04 | 2002-11-05 | Sepracor, Inc. | Diazabicyclo[4.3.0]nonanes, and methods of use thereof |
| ES2194588B1 (es) | 2001-07-13 | 2004-10-16 | Astur Pharma S.A. | Precursores opticamente puros de paroxetina. |
| US6995144B2 (en) | 2002-03-14 | 2006-02-07 | Eisai Co., Ltd. | Nitrogen containing heterocyclic compounds and medicines containing the same |
| PT2208727E (pt) | 2002-09-19 | 2012-10-11 | Lilly Co Eli | Éteres diarílicos como antagonista do receptor opióide |
| JP2006517567A (ja) | 2003-02-12 | 2006-07-27 | ニューロサーチ、アクティーゼルスカブ | 新規８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法 |
| DE10308350B4 (de) | 2003-02-27 | 2006-06-01 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 1,3-Cyclohexandiol-Derivaten |
| WO2005012716A1 (en) | 2003-07-25 | 2005-02-10 | Siemens Vdo Automotive Inc. | Integrated vapor control valve and sensor |
| JP2007507504A (ja) | 2003-09-30 | 2007-03-29 | メルク エンド カムパニー インコーポレーテッド | フェニルピロリジンエーテル系タキキニン受容体拮抗薬 |
| GB0327740D0 (en) | 2003-11-28 | 2003-12-31 | Glaxo Group Ltd | Novel compounds |
| WO2005068427A1 (ja) | 2004-01-14 | 2005-07-28 | Takeda Pharmaceutical Company Limited | カルボキサミド誘導体およびその用途 |
| KR20070015544A (ko) | 2004-04-14 | 2007-02-05 | 와이어쓰 | 라파마이신 42-에스테르 유도체의 위치특이성 합성 |
| CA2569611C (en) | 2004-06-21 | 2012-12-11 | F. Hoffmann-La Roche Ag | Indole derivatives as histamine receptor antagonists |
| DE602005023172D1 (de) | 2004-07-16 | 2010-10-07 | Schering Corp | Hydantoinderivate zur behandlung von entzündlichen erkrankungen |
| US7488745B2 (en) | 2004-07-16 | 2009-02-10 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| US7504424B2 (en) | 2004-07-16 | 2009-03-17 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| US7098203B2 (en) | 2004-07-20 | 2006-08-29 | Bristol-Myers Squibb Company | Homopiperidine derivatives as NK-1 antagonists |
| US7138423B2 (en) | 2004-07-20 | 2006-11-21 | Bristol-Myers Squibb Company | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists |
| GB0519957D0 (en) | 2005-09-30 | 2005-11-09 | Sb Pharmco Inc | Chemical compound |
| US7872023B2 (en) | 2005-02-17 | 2011-01-18 | Research Triangle Institute | Kappa opioid receptor ligands |
| TW200804307A (en) | 2005-10-27 | 2008-01-16 | Synta Pharmaceuticals Corp | Process for preparing mesylate salts of IL-12 inhibitory compounds |
| CA2631221C (en) | 2005-12-01 | 2014-06-03 | F. Hoffmann-La Roche Ag | Serotonin transporter (sert) inhibitors |
| US20070142389A1 (en) | 2005-12-20 | 2007-06-21 | Pfizer Inc. | Piperidine derivatives |
| AU2007225208A1 (en) | 2006-03-14 | 2007-09-20 | Amgen Inc. | Bicyclic carboxylic acid derivatives useful for treating metabolic disorders |
| WO2008012623A1 (en) | 2006-07-25 | 2008-01-31 | Pfizer Products Inc. | Benzimidazolyl compounds as potentiators of mglur2 subtype of glutamate receptor |
| US8470361B2 (en) | 2006-12-04 | 2013-06-25 | Orexo Ab | Non-abusable pharmaceutical composition comprising opioids |
| WO2008139484A2 (en) | 2007-05-16 | 2008-11-20 | R. L. Fine Chem | New process for the synthesis of loferpramine maleate: a stable salt of loferpramine |
| KR20100017372A (ko) | 2007-05-25 | 2010-02-16 | 애보트 게엠베하 운트 콤파니 카게 | 향대사성 글루타메이트 수용체 2（ｍｇｌｕ2 수용체）의 포지티브 조절자로서의 헤테로사이클릭 화합물 |
| US8962841B2 (en) | 2007-06-29 | 2015-02-24 | Brock University | Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids |
| JP2010535733A (ja) | 2007-08-07 | 2010-11-25 | エフ．ホフマン−ラ ロシュ アーゲー | Ｎｋ３受容体アンタゴニストとしてのピロリジンアリールエーテル |
| AU2008290634B2 (en) | 2007-08-22 | 2012-12-06 | F. Hoffmann-La Roche Ag | Pyrrolidine aryl-ether as NK3 receptor antagonists |
| GB0721178D0 (en) * | 2007-10-29 | 2007-12-05 | Glaxo Group Ltd | Chemical compounds |
| EA201000808A1 (ru) | 2007-11-16 | 2011-04-29 | Ньюраксон, Инк. | Индольные соединения и способы лечения висцеральной боли |
| WO2009072643A1 (en) | 2007-12-03 | 2009-06-11 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound and use thereof |
| US8394834B2 (en) | 2009-08-25 | 2013-03-12 | Hoffman-La Roche Inc. | Pyrrolidines as NK3 receptor antagonists |
| BR112012010253A8 (pt) | 2009-10-30 | 2016-10-04 | Janssen Pharmaceutica Nv | compostos de pirimidina como moduladores do receptor delta opioide |
| CN102753528A (zh) | 2009-12-04 | 2012-10-24 | 霍夫曼-拉罗奇有限公司 | 作为单胺重摄取抑制剂的二苯基氮杂*衍生物 |
| US8664214B2 (en) | 2010-03-30 | 2014-03-04 | AbbVie Deutschland GmbH & Co. KG | Small molecule potentiators of metabotropic glutamate receptors I |
| US8507535B2 (en) | 2010-07-07 | 2013-08-13 | Hoffmann-La Roche Inc. | Methyl-pyrrolidine ether derivatives |
| WO2012075232A1 (en) | 2010-12-04 | 2012-06-07 | Trevena, Inc. | Opioid receptor ligands and methods of using and making the same |
| ES2716865T3 (es) | 2011-02-18 | 2019-06-17 | Scripps Research Inst | Diferenciación dirigida de células precursoras de oligodendrocitos a un destino celular mielinizante |
| ME02754B (me) * | 2011-03-23 | 2018-01-20 | Trevena Inc | Ligandi opioidnih receptora i postupci njihove upotrebe i pripreme |
| WO2012129562A2 (en) | 2011-03-24 | 2012-09-27 | The Scripps Research Institute | Compounds and methods for inducing chondrogenesis |
| JP2014159375A (ja) | 2011-06-15 | 2014-09-04 | Takeda Chem Ind Ltd | アゼパン化合物 |
| US9168254B2 (en) | 2011-10-14 | 2015-10-27 | Array Biopharma Inc. | Polymorphs of ARRY-380, a selective HER 2 inhibitor and pharmaceutical compositions containing them |
| ES2586213T3 (es) | 2011-10-31 | 2016-10-13 | Xenon Pharmaceuticals Inc. | Compuestos de bencenosulfonamida y su uso como agentes terapéuticos |
| EP2810942B1 (en) | 2012-01-31 | 2016-03-30 | Eisai R&D Management Co., Ltd. | Paroxetine derivative |
| WO2013182612A1 (en) | 2012-06-07 | 2013-12-12 | Bayer Pharma Aktiengesellschaft | Glucose transport inhibitors |
| JP6250668B2 (ja) * | 2012-08-10 | 2017-12-20 | ヤンセン・サイエンシズ・アイルランド・ユーシー | 新しい抗菌化合物 |
| BR112015022758A2 (pt) | 2013-03-15 | 2017-07-18 | Abbvie Deutschland | derivados de pirrolidina, composições farmacêuticas contendo os mesmos e seu uso em terapia |
| WO2016029218A1 (en) * | 2014-08-22 | 2016-02-25 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Substituted 1-arylethyl-4-acylaminopiperidine derivatives as opioid/alpha-adrenoreceptor modulators and method of their preparation |
| WO2016210403A1 (en) | 2015-06-26 | 2016-12-29 | The Regents Of The University Of Michigan | G protein-coupled receptor kinase inhibitors and methods for use of the same |
| MA43313B1 (fr) | 2015-09-02 | 2022-06-30 | Trevena Inc | Aza-hétérocyclique à 6 éléments contenant des composés modulateurs de récepteurs opioïdes delta, et leurs procédés de fabrication et d'utilisation |
| CN110446495B (zh) | 2017-02-17 | 2023-09-05 | 特维娜有限公司 | 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
| CN110520129A (zh) | 2017-02-17 | 2019-11-29 | 特维娜有限公司 | 含有5元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
| CN110831593A (zh) * | 2017-06-14 | 2020-02-21 | 特维娜有限公司 | 用于调节s1p1活性的化合物及其使用方法 |
| MX2020007152A (es) | 2017-10-18 | 2020-12-10 | Epizyme Inc | Compuestos heterociclicos sustituidos con amina como inhibidores de ehmt2, sales de los mismos, y metodos de sintesis de los mismos. |
| CN111138425A (zh) | 2020-01-06 | 2020-05-12 | 中国药科大学 | 三氮唑类衍生物及其制备方法与用途 |
| CN116406268A (zh) | 2020-10-27 | 2023-07-07 | 特维娜有限公司 | δ-阿片样物质调节剂的结晶和无定形形式 |
| WO2023070605A1 (en) | 2021-10-29 | 2023-05-04 | Trevena, Inc. | Methods of preparing 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds |
-
2018
- 2018-02-15 CN CN201880018666.6A patent/CN110446495B/zh not_active Expired - Fee Related
- 2018-02-15 KR KR1020197026924A patent/KR102662065B1/ko active Active
- 2018-02-15 AU AU2018221705A patent/AU2018221705B2/en not_active Ceased
- 2018-02-15 EP EP18753604.0A patent/EP3582783B1/en active Active
- 2018-02-15 CA CA3052479A patent/CA3052479A1/en active Pending
- 2018-02-15 BR BR112019016775-7A patent/BR112019016775A2/pt not_active Application Discontinuation
- 2018-02-15 WO PCT/US2018/018303 patent/WO2018152286A1/en not_active Ceased
- 2018-02-15 US US16/486,539 patent/US11225487B2/en not_active Expired - Fee Related
- 2018-02-15 JP JP2019544622A patent/JP7185633B2/ja not_active Expired - Fee Related
-
2019
- 2019-08-01 IL IL268415A patent/IL268415B/en unknown
-
2021
- 2021-11-22 US US17/532,413 patent/US11912713B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018221705B2 (en) | 2022-10-27 |
| IL268415A (en) | 2019-09-26 |
| EP3582783B1 (en) | 2023-06-07 |
| EP3582783A1 (en) | 2019-12-25 |
| US11225487B2 (en) | 2022-01-18 |
| CN110446495A (zh) | 2019-11-12 |
| CN110446495B (zh) | 2023-09-05 |
| US20220348588A1 (en) | 2022-11-03 |
| US11912713B2 (en) | 2024-02-27 |
| KR20190117658A (ko) | 2019-10-16 |
| JP2020508301A (ja) | 2020-03-19 |
| EP3582783A4 (en) | 2020-09-02 |
| AU2018221705A1 (en) | 2019-08-29 |
| JP7185633B2 (ja) | 2022-12-07 |
| CA3052479A1 (en) | 2018-08-23 |
| KR102662065B1 (ko) | 2024-05-07 |
| WO2018152286A1 (en) | 2018-08-23 |
| BR112019016775A2 (pt) | 2020-03-31 |
| US20210061812A1 (en) | 2021-03-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL321626A (en) | Methods for selective regulation of the activity of distinct cell subtypes | |
| IL274570A (en) | STING-modulating compounds, and methods for their preparation and use | |
| PH12020550781A1 (en) | Anti-jagged1 antibodies and methods of use | |
| IL259803A (en) | Kinase Modulating Compounds and Methods and Labels Therefor | |
| IL268414A (en) | Delta-opioid receptor modulator compounds containing pentamerized aza-heterocycles, methods for their use and preparation | |
| ZA201800601B (en) | Novel breathing control modulating compounds, and methods of making and using same | |
| GB201707674D0 (en) | Porous liquids | |
| PH12017500877A1 (en) | ANTI-CD79b ANTIBODIES AND METHODS OF USE | |
| EP3104865A4 (en) | Micro-organoids, and methods of making and using the same | |
| EP3217925A4 (en) | Bone graft materials, devices and methods of use | |
| IL257503B (en) | Compounds containing a six-membered aza-heterocyclic ring that modulate the opioid-delta receptor, methods for their use and preparation | |
| GB201711157D0 (en) | Sulfur-Doped Carbonaceous porous materials | |
| IL273015A (en) | Beta-catenin functional modulators and methods thereof | |
| EP3238281A4 (en) | Resistive memory cells and precursors thereof, methods of making the same, and devices including the same | |
| SG11201910864UA (en) | Nanopore sequencers | |
| EP3454845A4 (en) | ADRENO RECEPTOR MODULATING CONNECTIONS AND METHOD FOR USE THEREOF | |
| GB2575532B (en) | Porous, wet-triggered shrinkable materials | |
| IL248792B (en) | hsp70 modulators and methods for their preparation and use | |
| SG11202101060WA (en) | Bicyclic compounds as kinase modulators, methods and uses thereof | |
| IL252758A0 (en) | An electrochemical reaction of oxygen with hydrocarbons | |
| EP3129868A4 (en) | Expandable application representation, milestones, and storylines | |
| GB201717112D0 (en) | Porous material | |
| GB2563095B (en) | Modulators | |
| EP3326662A4 (en) | USE OF POROUS MATERIAL | |
| HK40032207A (zh) | Sting调节剂化合物以及制备和使用方法 |