IL268414A - Delta-opioid receptor modulator compounds containing pentamerized aza-heterocycles, methods for their use and preparation - Google Patents
Delta-opioid receptor modulator compounds containing pentamerized aza-heterocycles, methods for their use and preparationInfo
- Publication number
- IL268414A IL268414A IL268414A IL26841419A IL268414A IL 268414 A IL268414 A IL 268414A IL 268414 A IL268414 A IL 268414A IL 26841419 A IL26841419 A IL 26841419A IL 268414 A IL268414 A IL 268414A
- Authority
- IL
- Israel
- Prior art keywords
- making
- methods
- same
- opioid receptor
- modulating compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762460407P | 2017-02-17 | 2017-02-17 | |
| PCT/US2018/018312 WO2018152293A1 (en) | 2017-02-17 | 2018-02-15 | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL268414A true IL268414A (en) | 2019-09-26 |
Family
ID=63169980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL268414A IL268414A (en) | 2017-02-17 | 2019-08-01 | Delta-opioid receptor modulator compounds containing pentamerized aza-heterocycles, methods for their use and preparation |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11702408B2 (enExample) |
| EP (1) | EP3582779B1 (enExample) |
| JP (1) | JP7316216B2 (enExample) |
| KR (1) | KR20190129867A (enExample) |
| CN (1) | CN110520129A (enExample) |
| AU (1) | AU2018221148B2 (enExample) |
| BR (1) | BR112019016827A2 (enExample) |
| CA (1) | CA3052480A1 (enExample) |
| IL (1) | IL268414A (enExample) |
| WO (1) | WO2018152293A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3052480A1 (en) | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| CN110446495B (zh) * | 2017-02-17 | 2023-09-05 | 特维娜有限公司 | 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
| US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| CN110117245B (zh) * | 2019-06-21 | 2021-03-02 | 浙江师范大学 | 一种jak抑制剂中间体的合成方法 |
| TW202140447A (zh) * | 2020-02-25 | 2021-11-01 | 義大利商Ｔｅｓ製藥（股份）責任有限公司 | 用於調節nr2f6之雜環化合物 |
Family Cites Families (69)
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| SE352811B (enExample) | 1971-06-04 | 1973-01-15 | Pharmacia Ab | |
| US3960150A (en) | 1971-09-09 | 1976-06-01 | Alza Corporation | Bioerodible ocular device |
| US3867519A (en) | 1972-04-27 | 1975-02-18 | Alza Corp | Bioerodible drug delivery device |
| SE375007B (enExample) | 1972-11-30 | 1975-04-07 | Pharmacia Ab | |
| US3963025A (en) | 1974-09-16 | 1976-06-15 | Alza Corporation | Ocular drug delivery device |
| JPS5825980B2 (ja) | 1976-02-12 | 1983-05-31 | ヤマサ醤油株式会社 | サイクリックヌクレオチドの定量法 |
| US4209514A (en) | 1977-06-24 | 1980-06-24 | Ciba-Geigy Corporation | 3-Aminoalkyl-4-aryl-tetrahydroazepines |
| US4186184A (en) | 1977-12-27 | 1980-01-29 | Alza Corporation | Selective administration of drug with ocular therapeutic system |
| US4303637A (en) | 1980-04-04 | 1981-12-01 | Alza Corporation | Medication indicated for ocular hypertension |
| DK231088D0 (da) | 1988-04-28 | 1988-04-28 | Ferrosan As | Piperidinforbindelser, deres fremstilling og anvendelse |
| US5086063A (en) | 1988-03-28 | 1992-02-04 | Du Pont Merck Pharmaceutical Company | 4-aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof |
| CA1337418C (en) | 1988-03-28 | 1995-10-24 | Engelbert Ciganek | 4-aryl-4-piperiding (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof |
| US5401629A (en) | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
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| MX2010001080A (es) | 2007-08-07 | 2010-03-01 | Hoffmann La Roche | Pirrolidin-aril-eteres como antagonistas de receptor de nk3. |
| ATE519738T1 (de) | 2007-08-22 | 2011-08-15 | Hoffmann La Roche | Pyrrolidinarylether als nk3-rezeptorantagonisten |
| GB0721178D0 (en) | 2007-10-29 | 2007-12-05 | Glaxo Group Ltd | Chemical compounds |
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| CL2008003595A1 (es) * | 2007-12-03 | 2009-11-20 | Takeda Pharmaceuticals Co | Compuestos heterociclicos nitrogenados, antagonistas del receptor de taquiquinina; agente farmaceutico que comprende el compuesto; y uso en la profilaxis o el tratamiento de una enfermedad del tracto urinario inferior, una enfermedad gastrointestinal o una enfermedad del sistema nervioso central. |
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| AU2010313401B2 (en) | 2009-10-30 | 2015-07-23 | Janssen Pharmaceutica Nv | Pyrimidine compounds as delta opioid receptor modulators |
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| JP6133790B2 (ja) | 2011-02-18 | 2017-05-24 | ザ スクリプス リサーチ インスティテュート | ミエリン形成細胞運命へのオリゴデンドロサイト前駆細胞の定方向分化 |
| PL3290415T3 (pl) | 2011-03-23 | 2021-07-19 | Trevena, Inc. | Ligandy receptora opioidowego oraz sposoby ich stosowania i wytwarzania |
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| CA2900888A1 (en) | 2013-03-15 | 2014-09-18 | AbbVie Deutschland GmbH & Co. KG | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9765027B2 (en) | 2014-08-22 | 2017-09-19 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Substituted 1-arylethyl-4-acylaminopiperidine derivatives as opioid/alpha-adrenoreceptor modulators and method of their preparation |
| EP3313396B1 (en) | 2015-06-26 | 2021-12-15 | The Regents of The University of Michigan | G protein-coupled receptor kinase inhibitors and methods for use of the same |
| EP3344248B1 (en) | 2015-09-02 | 2022-03-23 | Trevena, Inc. | 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| CA3052480A1 (en) | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| CN110446495B (zh) | 2017-02-17 | 2023-09-05 | 特维娜有限公司 | 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
-
2018
- 2018-02-15 CA CA3052480A patent/CA3052480A1/en active Pending
- 2018-02-15 KR KR1020197026926A patent/KR20190129867A/ko not_active Ceased
- 2018-02-15 JP JP2019544606A patent/JP7316216B2/ja active Active
- 2018-02-15 WO PCT/US2018/018312 patent/WO2018152293A1/en not_active Ceased
- 2018-02-15 EP EP18754875.5A patent/EP3582779B1/en active Active
- 2018-02-15 AU AU2018221148A patent/AU2018221148B2/en not_active Ceased
- 2018-02-15 US US16/486,541 patent/US11702408B2/en active Active
- 2018-02-15 CN CN201880025273.8A patent/CN110520129A/zh active Pending
- 2018-02-15 BR BR112019016827A patent/BR112019016827A2/pt not_active Application Discontinuation
-
2019
- 2019-08-01 IL IL268414A patent/IL268414A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN110520129A (zh) | 2019-11-29 |
| JP2020508300A (ja) | 2020-03-19 |
| US11702408B2 (en) | 2023-07-18 |
| BR112019016827A2 (pt) | 2020-04-07 |
| CA3052480A1 (en) | 2018-08-23 |
| US20210061790A1 (en) | 2021-03-04 |
| AU2018221148B2 (en) | 2022-05-05 |
| WO2018152293A1 (en) | 2018-08-23 |
| EP3582779B1 (en) | 2024-04-17 |
| AU2018221148A1 (en) | 2019-08-29 |
| EP3582779A4 (en) | 2020-07-29 |
| JP7316216B2 (ja) | 2023-07-27 |
| EP3582779A1 (en) | 2019-12-25 |
| KR20190129867A (ko) | 2019-11-20 |
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