IL266175B2 - Enhancement of msc immunomodulatory properties by treprostinil - Google Patents

Enhancement of msc immunomodulatory properties by treprostinil

Info

Publication number
IL266175B2
IL266175B2 IL266175A IL26617519A IL266175B2 IL 266175 B2 IL266175 B2 IL 266175B2 IL 266175 A IL266175 A IL 266175A IL 26617519 A IL26617519 A IL 26617519A IL 266175 B2 IL266175 B2 IL 266175B2
Authority
IL
Israel
Prior art keywords
msc
prostacyclin
exposed
pharmaceutical composition
treprostinil
Prior art date
Application number
IL266175A
Other languages
English (en)
Hebrew (he)
Other versions
IL266175A (en
IL266175B1 (en
Original Assignee
United Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United Therapeutics Corp filed Critical United Therapeutics Corp
Publication of IL266175A publication Critical patent/IL266175A/en
Publication of IL266175B1 publication Critical patent/IL266175B1/en
Publication of IL266175B2 publication Critical patent/IL266175B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
    • A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/02—Compounds of the arachidonic acid pathway, e.g. prostaglandins, leukotrienes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL266175A 2016-10-24 2017-10-23 Enhancement of msc immunomodulatory properties by treprostinil IL266175B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662411950P 2016-10-24 2016-10-24
PCT/US2017/057863 WO2018080990A1 (en) 2016-10-24 2017-10-23 Enhancement of msc immunomodulatory properties by treprostinil

Publications (3)

Publication Number Publication Date
IL266175A IL266175A (en) 2019-06-30
IL266175B1 IL266175B1 (en) 2023-09-01
IL266175B2 true IL266175B2 (en) 2024-01-01

Family

ID=60570174

Family Applications (1)

Application Number Title Priority Date Filing Date
IL266175A IL266175B2 (en) 2016-10-24 2017-10-23 Enhancement of msc immunomodulatory properties by treprostinil

Country Status (10)

Country Link
US (2) US11571444B2 (https=)
EP (1) EP3534917B1 (https=)
JP (1) JP7179723B2 (https=)
KR (1) KR102606101B1 (https=)
CN (1) CN110177559A (https=)
AU (1) AU2017350732B2 (https=)
CA (1) CA3041514A1 (https=)
ES (1) ES2927406T3 (https=)
IL (1) IL266175B2 (https=)
WO (1) WO2018080990A1 (https=)

Families Citing this family (8)

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ES2869701T3 (es) 2012-08-01 2021-10-25 United Therapeutics Corp Tratamiento de hipertensión arterial pulmonar con células progenitoras endoteliales tratadas con prostaciclina
JP6431850B2 (ja) 2013-01-09 2018-11-28 ユナイテッド セラピューティクス コーポレイション プロスタサイクリンおよび間葉系幹細胞による脈管障害の処置
JP7480454B2 (ja) * 2018-06-05 2024-05-10 メディポスト・カンパニー・リミテッド 有効成分として間葉系幹細胞を含む炎症性疾患の予防又は治療のための医薬組成物
KR20210089659A (ko) 2018-10-05 2021-07-16 제노세라퓨틱스, 인코포레이티드 이종이식 생성물 및 방법
US10883084B2 (en) 2018-10-05 2021-01-05 Xenotherapeutics, Inc. Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same
US12263189B2 (en) 2018-10-18 2025-04-01 Nantbio, Inc. Mesenchymal stem cell derived exosomes and methods
CN113274411A (zh) * 2021-04-21 2021-08-20 西安市第一医院 经基因修饰的骨髓间充质干细胞来源的微囊泡在制备治疗肾损伤药物中的应用
CN118576532B (zh) * 2024-08-05 2024-11-26 北京青藤谷禧干细胞科技研究院有限公司 一种含干细胞外泌体的面部美容组合物及其制备方法和应用

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US20140193379A1 (en) * 2013-01-09 2014-07-10 United Therapeutics Corporation Treatment of vasculopathy with prostacyclin and mesenchymal stem cells

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WO2014022373A1 (en) * 2012-08-01 2014-02-06 United Therapeutics Corporation Treatment of pulmonary arterial hypertension with mesenchymal stem cells
WO2014022376A2 (en) * 2012-08-01 2014-02-06 United Therapeutics Corporation Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells
US20140193379A1 (en) * 2013-01-09 2014-07-10 United Therapeutics Corporation Treatment of vasculopathy with prostacyclin and mesenchymal stem cells

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Also Published As

Publication number Publication date
IL266175A (en) 2019-06-30
US20180110807A1 (en) 2018-04-26
EP3534917B1 (en) 2022-08-24
CN110177559A (zh) 2019-08-27
KR20190101360A (ko) 2019-08-30
JP7179723B2 (ja) 2022-11-29
US20230137713A1 (en) 2023-05-04
AU2017350732A1 (en) 2019-06-06
AU2017350732B2 (en) 2023-07-27
ES2927406T3 (es) 2022-11-04
WO2018080990A1 (en) 2018-05-03
JP2019535677A (ja) 2019-12-12
KR102606101B1 (ko) 2023-11-27
US11571444B2 (en) 2023-02-07
EP3534917A1 (en) 2019-09-11
CA3041514A1 (en) 2018-05-03
IL266175B1 (en) 2023-09-01

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