IL266111B - Methods for promoting t cells response - Google Patents

Methods for promoting t cells response

Info

Publication number
IL266111B
IL266111B IL266111A IL26611119A IL266111B IL 266111 B IL266111 B IL 266111B IL 266111 A IL266111 A IL 266111A IL 26611119 A IL26611119 A IL 26611119A IL 266111 B IL266111 B IL 266111B
Authority
IL
Israel
Prior art keywords
cancer
clec
cells
antagonist
human
Prior art date
Application number
IL266111A
Other languages
English (en)
Hebrew (he)
Other versions
IL266111A (en
Inventor
Chiffoleau Elise
Teppaz Geraldine
Poirier Nicolas
Vanhove Bernard
Gauttier Vanessa
Original Assignee
Inst Nat Sante Rech Med
Ose Immunotherapeutics
Univ Nantes
Chiffoleau Elise
Teppaz Geraldine
Poirier Nicolas
Vanhove Bernard
Gauttier Vanessa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Ose Immunotherapeutics, Univ Nantes, Chiffoleau Elise, Teppaz Geraldine, Poirier Nicolas, Vanhove Bernard, Gauttier Vanessa filed Critical Inst Nat Sante Rech Med
Publication of IL266111A publication Critical patent/IL266111A/en
Publication of IL266111B publication Critical patent/IL266111B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1732Lectins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4726Lectins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056Lectin superfamily, e.g. CD23, CD72
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL266111A 2016-10-21 2017-10-20 Methods for promoting t cells response IL266111B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16306381 2016-10-21
EP17305988 2017-07-24
PCT/EP2017/076911 WO2018073440A1 (en) 2016-10-21 2017-10-20 Methods for promoting t cells response

Publications (2)

Publication Number Publication Date
IL266111A IL266111A (en) 2019-06-30
IL266111B true IL266111B (en) 2022-09-01

Family

ID=60293924

Family Applications (1)

Application Number Title Priority Date Filing Date
IL266111A IL266111B (en) 2016-10-21 2017-10-20 Methods for promoting t cells response

Country Status (21)

Country Link
US (3) US11365257B2 (OSRAM)
EP (2) EP3529262B1 (OSRAM)
JP (2) JP7032396B6 (OSRAM)
KR (1) KR102646708B1 (OSRAM)
CN (1) CN110291102A (OSRAM)
AU (1) AU2017345286B2 (OSRAM)
CA (1) CA3039348C (OSRAM)
CY (1) CY1124584T1 (OSRAM)
DK (1) DK3529262T3 (OSRAM)
ES (2) ES2883678T3 (OSRAM)
HR (1) HRP20211544T1 (OSRAM)
HU (1) HUE056016T2 (OSRAM)
IL (1) IL266111B (OSRAM)
LT (1) LT3529262T (OSRAM)
MA (1) MA46570B1 (OSRAM)
MD (1) MD3529262T2 (OSRAM)
PL (1) PL3529262T3 (OSRAM)
RS (1) RS62463B1 (OSRAM)
SI (1) SI3529262T1 (OSRAM)
SM (1) SMT202100555T1 (OSRAM)
WO (1) WO2018073440A1 (OSRAM)

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BR112019017751A2 (pt) 2017-02-28 2020-04-07 Vor Biopharma, Inc. composições e métodos de inibição de proteínas de linhagem específica
CN113423725A (zh) 2018-08-28 2021-09-21 Vor生物制药股份有限公司 遗传工程化造血干细胞及其用途
US20230331852A1 (en) * 2019-12-05 2023-10-19 Ose Immunotherapeutics Anti-clec-1a antibodies and antigen-binding fragment thereof
CN113156140A (zh) * 2021-03-05 2021-07-23 青岛大学附属医院 C型凝集素样受体-1作为真菌性角膜炎的治疗标志物的应用
JP7753401B2 (ja) * 2021-06-08 2025-10-14 オーエスイー・イミュノセラピューティクス ヒト化抗clec-1a抗体及びその抗原結合断片及びそのミメティック
JP2024542409A (ja) 2021-11-09 2024-11-15 オーエスイー・イミュノセラピューティクス Clec-1リガンドの同定及びその使用
WO2024028347A1 (en) 2022-08-01 2024-02-08 Ose Immunotherapeutics Heterodimeric fc-clec-1 fusion molecule and uses thereof
WO2025032213A1 (en) 2023-08-10 2025-02-13 Ose Immunotherapeutics Identification of hla-dra as a ligand of clec-1 and uses thereof

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US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
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Also Published As

Publication number Publication date
JP7404418B6 (ja) 2024-01-26
AU2017345286B2 (en) 2023-08-03
SMT202100555T1 (it) 2021-11-12
JP2020503252A (ja) 2020-01-30
DK3529262T3 (da) 2021-09-20
JP2022065159A (ja) 2022-04-26
KR102646708B1 (ko) 2024-03-12
ES2883678T3 (es) 2021-12-09
WO2018073440A1 (en) 2018-04-26
HRP20211544T1 (hr) 2022-01-07
JP7404418B2 (ja) 2023-12-25
MD3529262T2 (ro) 2022-01-31
US20240400695A1 (en) 2024-12-05
HUE056016T2 (hu) 2022-01-28
JP7032396B2 (ja) 2022-03-08
IL266111A (en) 2019-06-30
CY1124584T1 (el) 2022-07-22
MA46570A (fr) 2021-03-31
US20190309075A1 (en) 2019-10-10
EP3529262B1 (en) 2021-07-21
JP7032396B6 (ja) 2022-03-22
MA46570B1 (fr) 2021-10-29
PL3529262T3 (pl) 2021-12-27
SI3529262T1 (sl) 2021-12-31
KR20190068605A (ko) 2019-06-18
CA3039348C (en) 2023-09-05
US20220281983A1 (en) 2022-09-08
AU2017345286A1 (en) 2019-04-18
ES2978486T3 (es) 2024-09-13
US12091464B2 (en) 2024-09-17
EP3950709B1 (en) 2024-02-14
CA3039348A1 (en) 2018-04-26
EP3529262A1 (en) 2019-08-28
EP3950709A1 (en) 2022-02-09
CN110291102A (zh) 2019-09-27
RS62463B1 (sr) 2021-11-30
LT3529262T (lt) 2021-11-10
US11365257B2 (en) 2022-06-21

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