MA46570B1 - Procédés et compositions pharmaceutiques permettant de favoriser la réaction des lymphocytes t - Google Patents
Procédés et compositions pharmaceutiques permettant de favoriser la réaction des lymphocytes tInfo
- Publication number
- MA46570B1 MA46570B1 MA46570A MA46570A MA46570B1 MA 46570 B1 MA46570 B1 MA 46570B1 MA 46570 A MA46570 A MA 46570A MA 46570 A MA46570 A MA 46570A MA 46570 B1 MA46570 B1 MA 46570B1
- Authority
- MA
- Morocco
- Prior art keywords
- clec
- promoting
- methods
- lymphocytes
- reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4726—Lectins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1732—Lectins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Marine Sciences & Fisheries (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne des méthodes pour favoriser la réponse des lymphocytes t. Les inventeurs ont examiné l'expression et la fonction de clec-1 dans des cd humaines et démontré pour la première fois une expression de surface cellulaire. Ils ont étudié son rôle fonctionnel suite à un déclenchement sur l'orchestration des réponses des lymphocytes t. Les inventeurs ont montré in vitro et in vivo avec des rats déficients en clec-1 et une protéine de fusion clec-1 fc de rat que la perturbation de la signalisation de clec-1 améliore l'activation de th17 in vitro et améliore in vivo l'amorçage des lymphocytes t et l'activation de th17 et th1. En particulier, la présente invention concerne des antagonistes de clec-1 pour favoriser la réponse des lymphocytes t chez un sujet en ayant besoin.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16306381 | 2016-10-21 | ||
EP17305988 | 2017-07-24 | ||
PCT/EP2017/076911 WO2018073440A1 (fr) | 2016-10-21 | 2017-10-20 | Procédés pour favoriser la réponse des lymphocytes t |
Publications (2)
Publication Number | Publication Date |
---|---|
MA46570A MA46570A (fr) | 2021-03-31 |
MA46570B1 true MA46570B1 (fr) | 2021-10-29 |
Family
ID=60293924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA46570A MA46570B1 (fr) | 2016-10-21 | 2017-10-20 | Procédés et compositions pharmaceutiques permettant de favoriser la réaction des lymphocytes t |
Country Status (20)
Country | Link |
---|---|
US (2) | US11365257B2 (fr) |
EP (2) | EP3529262B1 (fr) |
JP (2) | JP7032396B6 (fr) |
KR (1) | KR102646708B1 (fr) |
CN (1) | CN110291102A (fr) |
AU (1) | AU2017345286B2 (fr) |
CA (1) | CA3039348C (fr) |
CY (1) | CY1124584T1 (fr) |
DK (1) | DK3529262T3 (fr) |
ES (1) | ES2883678T3 (fr) |
HR (1) | HRP20211544T1 (fr) |
HU (1) | HUE056016T2 (fr) |
IL (1) | IL266111B (fr) |
LT (1) | LT3529262T (fr) |
MA (1) | MA46570B1 (fr) |
MD (1) | MD3529262T2 (fr) |
PL (1) | PL3529262T3 (fr) |
RS (1) | RS62463B1 (fr) |
SI (1) | SI3529262T1 (fr) |
WO (1) | WO2018073440A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2017345286B2 (en) * | 2016-10-21 | 2023-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for promoting T cells response |
AU2018229351B2 (en) | 2017-02-28 | 2024-01-04 | Vor Biopharma, Inc. | Compositions and methods for inhibition of lineage specific proteins |
CN113423725A (zh) | 2018-08-28 | 2021-09-21 | Vor生物制药股份有限公司 | 遗传工程化造血干细胞及其用途 |
CN115151309A (zh) | 2019-12-05 | 2022-10-04 | Ose免疫疗法 | 抗clec-1a抗体及其抗原结合片段 |
WO2022258714A1 (fr) | 2021-06-08 | 2022-12-15 | Ose Immunotherapeutics | Anticorps humanisés anti-clec-1a et fragments de liaison à l'antigène de ceux-ci et mimétiques de ceux-ci |
WO2023083890A1 (fr) | 2021-11-09 | 2023-05-19 | Ose Immunotherapeutics | Identification de ligand clec-1 et ses utilisations |
WO2024028347A1 (fr) | 2022-08-01 | 2024-02-08 | Ose Immunotherapeutics | Molécule hybride fc-clec-1 hétérodimère et ses utilisations |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
DK1087013T3 (da) | 1992-08-21 | 2009-05-11 | Univ Bruxelles | Immunoglobuliner uden lette kæder |
US5618829A (en) | 1993-01-28 | 1997-04-08 | Mitsubishi Chemical Corporation | Tyrosine kinase inhibitors and benzoylacrylamide derivatives |
KR960703622A (ko) | 1993-07-15 | 1996-08-31 | 수잔 포오덴 | 단백질 티로신 키나아제 억제제의 프로드러그(prodrugs of protein tyrosine kinase inhibitors) |
EP0690452A3 (fr) | 1994-06-28 | 1999-01-07 | Advanced Micro Devices, Inc. | Mémoire électriquement effaçable et procédé d'effacement |
US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
EP0739981A1 (fr) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Fragments variables d'immunoglobulines-utilisation thérapeutique ou vétérinaire |
US5639757A (en) | 1995-05-23 | 1997-06-17 | Pfizer Inc. | 4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors |
DK0892789T4 (da) | 1996-04-12 | 2010-04-06 | Warner Lambert Co | Irreversible inhibitorer af tyrosin kinaser |
ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
US6100254A (en) | 1997-10-10 | 2000-08-08 | Board Of Regents, The University Of Texas System | Inhibitors of protein tyrosine kinases |
US6740665B1 (en) | 1999-02-10 | 2004-05-25 | Ramachandran Murali | Tyrosine kinase inhibitors and methods of using the same |
US6245759B1 (en) | 1999-03-11 | 2001-06-12 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
ATE253915T1 (de) | 1999-06-30 | 2003-11-15 | Merck & Co Inc | Src-kinase hemmende verbindungen |
EP1206260A4 (fr) | 1999-06-30 | 2002-10-30 | Merck & Co Inc | Composes inhibiteurs de la src kinase |
WO2001000214A1 (fr) | 1999-06-30 | 2001-01-04 | Merck & Co., Inc. | Composes inhibiteurs de la kinase src |
WO2001017995A1 (fr) | 1999-09-10 | 2001-03-15 | Merck & Co., Inc. | Inhibiteurs de tyrosine kinase |
AU778042B2 (en) | 1999-10-19 | 2004-11-11 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US6794393B1 (en) | 1999-10-19 | 2004-09-21 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
JP3822494B2 (ja) | 1999-10-19 | 2006-09-20 | メルク エンド カムパニー インコーポレーテッド | チロシンキナーゼ阻害剤 |
JP5007007B2 (ja) * | 1999-11-15 | 2012-08-22 | ミルテニイ バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 樹状細胞に特異的な抗原結合フラグメント、その組成物および使用方法、それによって認識される抗原およびそれによって得られる細胞 |
US6313138B1 (en) | 2000-02-25 | 2001-11-06 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US6420382B2 (en) | 2000-02-25 | 2002-07-16 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
JP2004535437A (ja) | 2001-06-22 | 2004-11-25 | メルク エンド カムパニー インコーポレーテッド | チロシンキナーゼ阻害剤 |
US6958340B2 (en) | 2001-08-01 | 2005-10-25 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
WO2003020276A1 (fr) | 2001-08-30 | 2003-03-13 | Merck & Co., Inc. | Inhibiteurs de tyrosine kinase |
US8246959B1 (en) * | 2003-08-01 | 2012-08-21 | University Of Washington | Dendritic cell-associated lectin-like molecules, compositions and methods of use |
WO2007109571A2 (fr) | 2006-03-17 | 2007-09-27 | Prometheus Laboratories, Inc. | Procédés de prédiction et de suivi de la thérapie par l'inhibiteur de la tyrosine kinase |
WO2008103947A2 (fr) * | 2007-02-23 | 2008-08-28 | Baylor Research Institute | Activation de cellules humaines présentant un antigène par l'intermédiaire de clec-6 |
US20130058957A1 (en) * | 2010-02-23 | 2013-03-07 | The University Of Tokyo | Dendritic cell immunoreceptor agonist |
RU2741120C2 (ru) * | 2014-07-21 | 2021-01-22 | Новартис Аг | Лечение рака с использованием химерного антигенного рецептора cll-1 |
AU2017345286B2 (en) | 2016-10-21 | 2023-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for promoting T cells response |
-
2017
- 2017-10-20 AU AU2017345286A patent/AU2017345286B2/en active Active
- 2017-10-20 DK DK17797066.2T patent/DK3529262T3/da active
- 2017-10-20 KR KR1020197014209A patent/KR102646708B1/ko active IP Right Grant
- 2017-10-20 US US16/343,757 patent/US11365257B2/en active Active
- 2017-10-20 LT LTEPPCT/EP2017/076911T patent/LT3529262T/lt unknown
- 2017-10-20 JP JP2019521034A patent/JP7032396B6/ja active Active
- 2017-10-20 HR HRP20211544TT patent/HRP20211544T1/hr unknown
- 2017-10-20 MA MA46570A patent/MA46570B1/fr unknown
- 2017-10-20 IL IL266111A patent/IL266111B/en unknown
- 2017-10-20 EP EP17797066.2A patent/EP3529262B1/fr active Active
- 2017-10-20 WO PCT/EP2017/076911 patent/WO2018073440A1/fr active Application Filing
- 2017-10-20 CN CN201780065072.6A patent/CN110291102A/zh active Pending
- 2017-10-20 RS RS20211221A patent/RS62463B1/sr unknown
- 2017-10-20 ES ES17797066T patent/ES2883678T3/es active Active
- 2017-10-20 HU HUE17797066A patent/HUE056016T2/hu unknown
- 2017-10-20 PL PL17797066T patent/PL3529262T3/pl unknown
- 2017-10-20 CA CA3039348A patent/CA3039348C/fr active Active
- 2017-10-20 SI SI201730876T patent/SI3529262T1/sl unknown
- 2017-10-20 MD MDE20190953T patent/MD3529262T2/ro unknown
- 2017-10-20 EP EP21178847.6A patent/EP3950709B1/fr active Active
-
2021
- 2021-09-24 CY CY20211100839T patent/CY1124584T1/el unknown
-
2022
- 2022-02-22 JP JP2022025697A patent/JP7404418B6/ja active Active
- 2022-05-10 US US17/740,849 patent/US20220281983A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA46570B1 (fr) | Procédés et compositions pharmaceutiques permettant de favoriser la réaction des lymphocytes t | |
Chapman et al. | mTOR signaling, Tregs and immune modulation | |
Eriksson et al. | Inhibitory receptors alter natural killer cell interactions with target cells yet allow simultaneous killing of susceptible targets | |
Ritzel et al. | Age-associated resident memory CD8 T cells in the central nervous system are primed to potentiate inflammation after ischemic brain injury | |
Tennakoon et al. | Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosis | |
Zhang et al. | Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node | |
Hedrich et al. | Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human NaV1. 1 mutation | |
Huh et al. | A novel function of adipocytes in lipid antigen presentation to iNKT cells | |
Le Rond et al. | Evidence to support the role of HLA-G5 in allograft acceptance through induction of immunosuppressive/regulatory T cells | |
Marko et al. | Age-associated decline in effective immune synapse formation of CD4+ T cells is reversed by vitamin E supplementation | |
Churina et al. | The role of foxp3‐expressing regulatory T cells and T helpers in immunopathogenesis of multidrug resistant pulmonary tuberculosis | |
Hong et al. | TiO2 nanoparticle exposure decreases spermatogenesis via biochemical dysfunctions in the testis of male mice | |
Marcel et al. | Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells | |
Lohr et al. | Role of B7 in T cell tolerance | |
Guardiola-Serrano et al. | Palmitoylation of human FasL modulates its cell death-inducing function | |
Gregori et al. | An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells | |
Xia et al. | TCR and CD28 concomitant stimulation elicits a distinctive calcium response in naive T cells | |
Garcia Santana et al. | Human treg cells are characterized by low/negative CD6 expression | |
Boldison et al. | Tissue-resident exhausted effector memory CD8+ T cells accumulate in the retina during chronic experimental autoimmune uveoretinitis | |
Brant et al. | Role of the aryl hydrocarbon receptor in the immune response profile and development of pathology during Plasmodium berghei Anka infection | |
Braunstein et al. | The role of L-and T-type calcium channels in local and remote calcium responses in rat mesenteric terminal arterioles | |
Schuldt et al. | Cutting edge: Dual TCRα expression poses an autoimmune hazard by limiting regulatory T cell generation | |
Thedrez et al. | CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells | |
Pierau et al. | Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation | |
Caton et al. | Strength of TCR signal from self‐peptide modulates autoreactive thymocyte deletion and F oxp3+ T reg‐cell formation |