IL256912B1 - שיטות לטיפול בהפרעות התפתחותיות עם גבוקסאדול - Google Patents
שיטות לטיפול בהפרעות התפתחותיות עם גבוקסאדולInfo
- Publication number
- IL256912B1 IL256912B1 IL256912A IL25691218A IL256912B1 IL 256912 B1 IL256912 B1 IL 256912B1 IL 256912 A IL256912 A IL 256912A IL 25691218 A IL25691218 A IL 25691218A IL 256912 B1 IL256912 B1 IL 256912B1
- Authority
- IL
- Israel
- Prior art keywords
- gaboxadol
- methods
- developmental disorders
- treating developmental
- treating
- Prior art date
Links
- 208000012239 Developmental disease Diseases 0.000 title 1
- ZXRVKCBLGJOCEE-UHFFFAOYSA-N Gaboxadol Chemical compound C1NCCC2=C1ONC2=O ZXRVKCBLGJOCEE-UHFFFAOYSA-N 0.000 title 1
- 229950004346 gaboxadol Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562193717P | 2015-07-17 | 2015-07-17 | |
US201562207595P | 2015-08-20 | 2015-08-20 | |
US201662332567P | 2016-05-06 | 2016-05-06 | |
US201662346763P | 2016-06-07 | 2016-06-07 | |
PCT/US2016/042238 WO2017015049A1 (en) | 2015-07-17 | 2016-07-14 | Methods of treating developmental disorders with gaboxadol |
US15/209,862 US20170014393A1 (en) | 2015-07-17 | 2016-07-14 | Methods of treating developmental disorders with gaboxadol |
Publications (3)
Publication Number | Publication Date |
---|---|
IL256912A IL256912A (he) | 2018-03-29 |
IL256912B1 true IL256912B1 (he) | 2023-09-01 |
IL256912B2 IL256912B2 (he) | 2024-01-01 |
Family
ID=57774846
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL305342A IL305342A (he) | 2015-07-17 | 2016-07-14 | שיטות לטיפול בהפרעות התפתחותיות עם גבוקסאדול |
IL256912A IL256912B2 (he) | 2015-07-17 | 2016-07-14 | שיטות לטיפול בהפרעות התפתחותיות עם גבוקסאדול |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL305342A IL305342A (he) | 2015-07-17 | 2016-07-14 | שיטות לטיפול בהפרעות התפתחותיות עם גבוקסאדול |
Country Status (16)
Country | Link |
---|---|
US (8) | US20170014393A1 (he) |
EP (1) | EP3324961A4 (he) |
JP (3) | JP2018520189A (he) |
KR (1) | KR20180031721A (he) |
CN (2) | CN108024997A (he) |
AU (2) | AU2016295138B2 (he) |
BR (1) | BR112018000933A2 (he) |
CA (1) | CA2992734A1 (he) |
CL (1) | CL2018000142A1 (he) |
CO (1) | CO2018000375A2 (he) |
HK (1) | HK1250951A1 (he) |
IL (2) | IL305342A (he) |
MX (2) | MX2018000745A (he) |
PE (2) | PE20230735A1 (he) |
TW (2) | TW202325293A (he) |
WO (1) | WO2017015049A1 (he) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS62006B1 (sr) | 2014-06-06 | 2021-07-30 | Ovid Therapeutics Inc | Postupci pojačavanja tonične inhibicije i lečenja sekundarne nesanice |
AU2016295138B2 (en) * | 2015-07-17 | 2021-11-04 | Ovid Therapeutics Inc. | Methods of treating developmental disorders with gaboxadol |
KR102518846B1 (ko) | 2016-08-11 | 2023-04-05 | 오비드 테라퓨틱스 인크. | 간질 장애의 치료를 위한 방법 및 조성물 |
CN110225754A (zh) * | 2016-11-22 | 2019-09-10 | 奥维德医疗公司 | 用氟吡汀治疗发育障碍和/或癫痫发作紊乱的方法 |
US10071083B2 (en) | 2017-02-03 | 2018-09-11 | Ovid Therapeutics Inc | Use of gaboxadol in the treatment of tinnitus |
US20180338959A1 (en) * | 2017-05-24 | 2018-11-29 | Ovid Therapeutics Inc. | Treatment of depressive disorders |
MX2020001342A (es) | 2017-08-04 | 2020-08-31 | Ovid Therapeutics Inc | Uso de gaboxadol en el tratamiento contra diabetes y afecciones relacionadas. |
CN112739353A (zh) * | 2018-06-14 | 2021-04-30 | 奥维德医疗公司 | Mir-92a或mir-145在治疗安格曼综合征中的用途 |
CA3110218A1 (en) * | 2018-08-22 | 2020-02-27 | Ovid Therapeutics Inc. | Use of gaboxadol in the treatment of gastrointestinal tract disorders and asthma |
MX2021003302A (es) * | 2018-09-20 | 2021-05-13 | Ovid Therapeutics Inc | Uso de gaboxadol para el tratamiento del sindrome de tourette, los tics y la tartamudez. |
US11123332B2 (en) | 2018-11-21 | 2021-09-21 | Certego Therapeutics Inc. | Gaboxadol for reducing risk of suicide and rapid relief of depression |
AU2019384561A1 (en) * | 2018-11-21 | 2021-06-10 | Certego Therapeutics Inc. | Combination of gaboxadol and lithium for the treatment of psychiatric disorders |
KR20210105387A (ko) | 2018-12-17 | 2021-08-26 | 오비드 테라퓨틱스 인크. | 비-24 시간 수면-각성 장애의 치료를 위한 가복사돌의 사용 |
WO2020247127A1 (en) * | 2019-06-07 | 2020-12-10 | Paxmedica, Inc. | Compositions and methods for treating central nervous system disorders |
KR20220035195A (ko) * | 2019-07-15 | 2022-03-21 | 오비드 테라퓨틱스 인크. | 치료적 치료를 위한 가복사돌을 포함하는 약학적 제제 |
CN114786669A (zh) * | 2019-12-18 | 2022-07-22 | 奥维德医疗公司 | 用于1p36缺失综合征的治疗性治疗的加波沙朵 |
IL298334A (he) | 2020-05-20 | 2023-01-01 | Certego Therapeutics Inc | טבעת גבוקסאדול מבוטלת והשימוש בה לטיפול בהפרעות פסיכיאטריות |
Citations (4)
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US20030077297A1 (en) * | 1999-02-26 | 2003-04-24 | Feng-Jing Chen | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
WO2006013397A1 (en) * | 2004-08-06 | 2006-02-09 | Merck Sharp & Dohme Limited | Combination of gaboxadol and 5ht2a antagonists |
US20080269278A1 (en) * | 2004-04-02 | 2008-10-30 | H. Lundbeck A/S | Treatment of Impaired Respiratory Function with Gaboxadol |
US20090143335A1 (en) * | 2007-10-29 | 2009-06-04 | H. Lundbeck A/S | Modified absorption formulation of gaboxadol |
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US2830083A (en) | 1953-04-29 | 1958-04-08 | Allied Chem & Dye Corp | Production of aryloxy aliphatic carboxylic acids |
US4084000A (en) | 1975-07-16 | 1978-04-11 | Nelson Research And Development Company | Method of treating schizophrenia |
US4138484A (en) | 1976-08-16 | 1979-02-06 | Nelson Research & Development Company | Method for treating schizophrenia and method and composition for potentiating neuroleptic drugs |
US4129652A (en) | 1976-08-16 | 1978-12-12 | Nelson Research & Development Company | Method for potentiating neuroleptic drugs |
DK270378A (da) | 1977-06-20 | 1978-12-21 | Krogsgaard Larsen P | Isoxazolderivater |
US4362731A (en) | 1980-09-01 | 1982-12-07 | Sandoz Ltd. | Myotonolytic use of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridin-3-ol and derivatives thereof |
US4353910A (en) | 1981-11-27 | 1982-10-12 | Kefalas A/S | Derivatives of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-one, pharmaceutical compositions and methods of treatment |
JPS61277618A (ja) | 1985-06-04 | 1986-12-08 | Suntory Ltd | 自閉症治療剤 |
DE19525598C2 (de) | 1995-07-13 | 1997-09-25 | Max Planck Gesellschaft | Schlafmittel |
DE19526864A1 (de) | 1995-07-22 | 1997-01-23 | Labtec Gmbh | Hormonpflaster |
US6461644B1 (en) | 1996-03-25 | 2002-10-08 | Richard R. Jackson | Anesthetizing plastics, drug delivery plastics, and related medical products, systems and methods |
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AU2002227052A1 (en) * | 2000-11-30 | 2002-06-11 | University Of Florida | Treatments for neurogenetic disorders, impulse control disorders, and wound healing |
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US20050234093A1 (en) * | 2003-06-25 | 2005-10-20 | H. Lundbeck A/S | Treatment of depression and other affective disorders |
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KR20070010136A (ko) * | 2004-04-02 | 2007-01-22 | 하. 룬트벡 아크티에 셀스카브 | 가복사돌을 이용한 손상된 호흡 기능의 치료 |
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EP2334299A1 (en) * | 2008-09-01 | 2011-06-22 | H. Lundbeck A/S | Pharmaceutical composition comprising gaboxadol and an inhibitor of patl or oat |
CN102147667A (zh) | 2010-02-08 | 2011-08-10 | 深圳富泰宏精密工业有限公司 | 触控笔 |
EP2621282B1 (en) | 2010-09-28 | 2020-04-15 | The Regents of The University of California | Gaba agonists in the treatment of disorders associated with metabolic syndrome and gaba combinations in treatment or prophylaxis of type i diabetes |
WO2012075286A2 (en) | 2010-12-01 | 2012-06-07 | The Regents Of The University Of California | Intrapulmonary benzodiazepine for the treatment and prevention of seizures |
EP2765989B1 (en) | 2011-10-13 | 2016-04-13 | Jaleva Pharmaceuticals LLC | Methods and compositions for rapid transbuccal delivery of active agents |
EP2925327B1 (en) * | 2012-11-30 | 2024-01-10 | The Regents of The University of California | Allopregnanolone for treating, reducing or mitigating symptoms of post-partum depression |
WO2014123909A1 (en) | 2013-02-05 | 2014-08-14 | University Of Washington Through Its Center For Commercialization | Positive allosteric modulators of the gaba-a receptor in the treatment of autism |
RS62006B1 (sr) * | 2014-06-06 | 2021-07-30 | Ovid Therapeutics Inc | Postupci pojačavanja tonične inhibicije i lečenja sekundarne nesanice |
WO2015189744A1 (en) | 2014-06-12 | 2015-12-17 | Pfizer Limited | Imidazopyridazine derivatives as modulators of the gabaa receptor activity. |
US20170348232A1 (en) | 2016-06-07 | 2017-12-07 | Ovid Therapeutics Inc. | Formulations of gaboxadol for treatment of angelman syndrome, fragile x syndrome and fragile x-associated tremor/ataxia syndrome |
AU2016295138B2 (en) | 2015-07-17 | 2021-11-04 | Ovid Therapeutics Inc. | Methods of treating developmental disorders with gaboxadol |
US9682069B2 (en) | 2015-07-17 | 2017-06-20 | Ovid Therapeutics Inc | Methods of treating Dravet syndrome |
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US9351968B1 (en) | 2015-09-09 | 2016-05-31 | Ovid Therapeutics Inc | Methods of treating developmental disorders using pipradrol |
KR102518846B1 (ko) | 2016-08-11 | 2023-04-05 | 오비드 테라퓨틱스 인크. | 간질 장애의 치료를 위한 방법 및 조성물 |
US10071083B2 (en) | 2017-02-03 | 2018-09-11 | Ovid Therapeutics Inc | Use of gaboxadol in the treatment of tinnitus |
-
2016
- 2016-07-14 AU AU2016295138A patent/AU2016295138B2/en active Active
- 2016-07-14 EP EP16828266.3A patent/EP3324961A4/en active Pending
- 2016-07-14 IL IL305342A patent/IL305342A/he unknown
- 2016-07-14 WO PCT/US2016/042238 patent/WO2017015049A1/en active Application Filing
- 2016-07-14 US US15/209,862 patent/US20170014393A1/en not_active Abandoned
- 2016-07-14 CA CA2992734A patent/CA2992734A1/en active Pending
- 2016-07-14 PE PE2022002752A patent/PE20230735A1/es unknown
- 2016-07-14 KR KR1020187004863A patent/KR20180031721A/ko not_active Application Discontinuation
- 2016-07-14 CN CN201680054308.1A patent/CN108024997A/zh active Pending
- 2016-07-14 CN CN202310549878.XA patent/CN116531370A/zh active Pending
- 2016-07-14 JP JP2018502084A patent/JP2018520189A/ja not_active Withdrawn
- 2016-07-14 PE PE2018000085A patent/PE20190338A1/es unknown
- 2016-07-14 IL IL256912A patent/IL256912B2/he unknown
- 2016-07-14 MX MX2018000745A patent/MX2018000745A/es unknown
- 2016-07-14 BR BR112018000933A patent/BR112018000933A2/pt not_active Application Discontinuation
- 2016-07-15 TW TW112110413A patent/TW202325293A/zh unknown
- 2016-07-15 TW TW105122538A patent/TWI819995B/zh active
-
2017
- 2017-12-13 US US15/840,521 patent/US20180098974A1/en not_active Abandoned
-
2018
- 2018-01-17 CL CL2018000142A patent/CL2018000142A1/es unknown
- 2018-01-17 MX MX2022004734A patent/MX2022004734A/es unknown
- 2018-01-22 CO CONC2018/0000375A patent/CO2018000375A2/es unknown
- 2018-08-02 US US16/053,343 patent/US20180338960A1/en not_active Abandoned
- 2018-08-15 HK HK18110494.0A patent/HK1250951A1/zh unknown
- 2018-12-17 US US16/221,794 patent/US11096929B2/en active Active
-
2019
- 2019-05-01 US US16/400,227 patent/US20190255027A1/en not_active Abandoned
- 2019-06-25 US US16/451,591 patent/US20190321342A1/en not_active Abandoned
-
2020
- 2020-06-25 US US16/911,540 patent/US20210030727A1/en not_active Abandoned
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2021
- 2021-05-25 JP JP2021087584A patent/JP2021130687A/ja active Pending
- 2021-10-12 AU AU2021250862A patent/AU2021250862B2/en active Active
-
2022
- 2022-11-04 US US17/981,148 patent/US20230071127A1/en active Pending
-
2023
- 2023-05-16 JP JP2023080696A patent/JP2023103375A/ja active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030077297A1 (en) * | 1999-02-26 | 2003-04-24 | Feng-Jing Chen | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
US20080269278A1 (en) * | 2004-04-02 | 2008-10-30 | H. Lundbeck A/S | Treatment of Impaired Respiratory Function with Gaboxadol |
WO2006013397A1 (en) * | 2004-08-06 | 2006-02-09 | Merck Sharp & Dohme Limited | Combination of gaboxadol and 5ht2a antagonists |
US20090143335A1 (en) * | 2007-10-29 | 2009-06-04 | H. Lundbeck A/S | Modified absorption formulation of gaboxadol |
Non-Patent Citations (5)
Title |
---|
EIXOTO M F ET AL,, EFFECTS OF GABAERGIC DRUGS ON RESERPINE-INDUCED ORAL DYSKINESIA, 7 May 2005 (2005-05-07) * |
GUNVANT K. THAKER,, BRAIN [GAMMA]-AMINOBUTYRIC ACID ABNORMALITY IN TARDIVE DYSKINESIA : REDUCTION IN CEREBROSPINAL FLUID GABA LEVELS AND THERAPEUTIC RESPONSE TO GABA AGONIST TREATMENT, 1 June 1987 (1987-06-01) * |
K. EGAWA ET AL, DECREASED TONIC INHIBITION IN CEREBELLAR GRANULE CELLS CAUSES MOTOR DYSFUNCTION IN A MOUSE MODEL OF ANGELMAN SYNDROME, 5 December 2012 (2012-12-05) * |
LOZANO REYMUNDO ET AL,, MODULATION OF THE GABAERGIC PATHWAY FOR THE TREATMENT OF FRAGILE X SYNDROME, 1 January 2014 (2014-01-01) * |
OLMOS-SERRANO J. L. ET AL.,, THE GABA(A) RECEPTOR AGONIST THIP AMELIORATES SPECIFIC BEHAVIORAL DEFICITS IN THE MOUSE MODEL OF FRAGILE X SYNDROME, 31 December 2011 (2011-12-31) * |
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