IL254712A0 - A process for the preparation of aclidinium bromide - Google Patents
A process for the preparation of aclidinium bromideInfo
- Publication number
- IL254712A0 IL254712A0 IL254712A IL25471217A IL254712A0 IL 254712 A0 IL254712 A0 IL 254712A0 IL 254712 A IL254712 A IL 254712A IL 25471217 A IL25471217 A IL 25471217A IL 254712 A0 IL254712 A0 IL 254712A0
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- aclidinium bromide
- aclidinium
- bromide
- Prior art date
Links
- ASMXXROZKSBQIH-VITNCHFBSA-N aclidinium Chemical compound C([C@@H](C(CC1)CC2)OC(=O)C(O)(C=3SC=CC=3)C=3SC=CC=3)[N+]21CCCOC1=CC=CC=C1 ASMXXROZKSBQIH-VITNCHFBSA-N 0.000 title 1
- 229960005012 aclidinium bromide Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0018—Evaporation of components of the mixture to be separated
- B01D9/0027—Evaporation of components of the mixture to be separated by means of conveying fluid, e.g. spray-crystallisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Otolaryngology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Catalysts (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT10837015A PT108370B (pt) | 2015-03-30 | 2015-03-30 | Processo de preparação de brometo de aclidínio |
| PCT/GB2016/050888 WO2016156836A1 (en) | 2015-03-30 | 2016-03-30 | Process for the preparation of aclidinium bromide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL254712A0 true IL254712A0 (en) | 2017-11-30 |
Family
ID=55806548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL254712A IL254712A0 (en) | 2015-03-30 | 2017-09-26 | A process for the preparation of aclidinium bromide |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10087177B2 (enExample) |
| EP (1) | EP3277679A1 (enExample) |
| JP (4) | JP2018510189A (enExample) |
| CN (1) | CN108112252B (enExample) |
| AU (1) | AU2016240289B2 (enExample) |
| CA (2) | CA3165243A1 (enExample) |
| IL (1) | IL254712A0 (enExample) |
| PT (1) | PT108370B (enExample) |
| WO (1) | WO2016156836A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT108370B (pt) | 2015-03-30 | 2018-10-25 | Hovione Farm S A | Processo de preparação de brometo de aclidínio |
| CN108586450B (zh) * | 2017-12-15 | 2021-02-19 | 上海方予健康医药科技有限公司 | 一种胆碱m受体抗结剂的重结晶纯化方法 |
| PT115583B (pt) * | 2019-06-17 | 2022-05-02 | Hovione Farm S A | Processo contínuo para a preparação de medicamentos anticolinérgicos |
| CN114890997A (zh) * | 2022-04-20 | 2022-08-12 | 江苏联环药业股份有限公司 | 一种抗胆碱能药物噻格溴铵的制备工艺 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| IL150524A0 (en) * | 2000-01-07 | 2003-02-12 | Transform Pharmaceuticals Inc | High-throughput formation, identification, and analysis of diverse solid-forms |
| US6482847B2 (en) * | 2000-10-03 | 2002-11-19 | Hoffmann-La Roche Inc. | Amorphous form of cell cycle inhibitor having improved solubility and bioavailability |
| AR044134A1 (es) * | 2003-05-02 | 2005-08-24 | Novartis Ag | Derivados de quinuclidina, metodo de preparacion y composiciones farmaceuticas. |
| PT1651270E (pt) * | 2003-07-29 | 2007-04-30 | Boehringer Ingelheim Int | Medicamentos para inalação compreendendo betamiméticos e um anticolinérgico |
| LT1993360T (lt) * | 2005-12-28 | 2017-06-12 | Vertex Pharmaceuticals Incorporated | N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma |
| ES2298049B1 (es) * | 2006-07-21 | 2009-10-20 | Laboratorios Almirall S.A. | Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano. |
| JP6389174B2 (ja) * | 2012-08-15 | 2018-09-12 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | 化学的方法 |
| CZ306791B6 (cs) | 2013-10-29 | 2017-07-12 | Zentiva, K.S. | Průmyslově využitelný způsob přípravy aklidinium bromidu o vysoké čistotě |
| WO2015071824A1 (en) | 2013-11-13 | 2015-05-21 | Glenmark Pharmaceuticals Limited; Glenmark Generics Limited | Process for the preparation of aclidinium bromide |
| PT108370B (pt) | 2015-03-30 | 2018-10-25 | Hovione Farm S A | Processo de preparação de brometo de aclidínio |
-
2015
- 2015-03-30 PT PT10837015A patent/PT108370B/pt active IP Right Grant
-
2016
- 2016-03-30 CA CA3165243A patent/CA3165243A1/en active Pending
- 2016-03-30 CN CN201680031574.2A patent/CN108112252B/zh not_active Expired - Fee Related
- 2016-03-30 WO PCT/GB2016/050888 patent/WO2016156836A1/en not_active Ceased
- 2016-03-30 JP JP2017551330A patent/JP2018510189A/ja active Pending
- 2016-03-30 AU AU2016240289A patent/AU2016240289B2/en not_active Ceased
- 2016-03-30 EP EP16717989.4A patent/EP3277679A1/en not_active Withdrawn
- 2016-03-30 US US15/562,814 patent/US10087177B2/en active Active
- 2016-03-30 CA CA2980665A patent/CA2980665A1/en active Pending
-
2017
- 2017-09-26 IL IL254712A patent/IL254712A0/en unknown
-
2018
- 2018-08-28 US US16/114,714 patent/US10590124B2/en not_active Expired - Fee Related
-
2020
- 2020-06-04 JP JP2020097781A patent/JP2020143160A/ja active Pending
- 2020-11-05 JP JP2020185042A patent/JP7124035B2/ja not_active Expired - Fee Related
-
2022
- 2022-08-10 JP JP2022128244A patent/JP2022160667A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US10087177B2 (en) | 2018-10-02 |
| JP2021020965A (ja) | 2021-02-18 |
| EP3277679A1 (en) | 2018-02-07 |
| US10590124B2 (en) | 2020-03-17 |
| JP2018510189A (ja) | 2018-04-12 |
| JP2022160667A (ja) | 2022-10-19 |
| AU2016240289A1 (en) | 2017-10-19 |
| JP2020143160A (ja) | 2020-09-10 |
| CN108112252A (zh) | 2018-06-01 |
| PT108370B (pt) | 2018-10-25 |
| CA3165243A1 (en) | 2016-10-06 |
| CN108112252B (zh) | 2020-11-24 |
| WO2016156836A1 (en) | 2016-10-06 |
| JP7124035B2 (ja) | 2022-08-23 |
| US20180362523A1 (en) | 2018-12-20 |
| AU2016240289B2 (en) | 2020-08-27 |
| US20180105517A1 (en) | 2018-04-19 |
| PT108370A (pt) | 2016-09-30 |
| CA2980665A1 (en) | 2016-10-06 |
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