IL250804A0 - Imaging means for the huntingtin protein - Google Patents
Imaging means for the huntingtin proteinInfo
- Publication number
- IL250804A0 IL250804A0 IL250804A IL25080417A IL250804A0 IL 250804 A0 IL250804 A0 IL 250804A0 IL 250804 A IL250804 A IL 250804A IL 25080417 A IL25080417 A IL 25080417A IL 250804 A0 IL250804 A0 IL 250804A0
- Authority
- IL
- Israel
- Prior art keywords
- probes
- huntingtin protein
- imaging
- imaging huntingtin
- protein
- Prior art date
Links
- 102000016252 Huntingtin Human genes 0.000 title 1
- 108050004784 Huntingtin Proteins 0.000 title 1
- 238000003384 imaging method Methods 0.000 title 1
- 239000000523 sample Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/0412—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K51/0419—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462043617P | 2014-08-29 | 2014-08-29 | |
| PCT/US2015/047427 WO2016033460A1 (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL250804A0 true IL250804A0 (en) | 2017-04-30 |
Family
ID=55400659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL250804A IL250804A0 (en) | 2014-08-29 | 2017-02-27 | Imaging means for the huntingtin protein |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10907197B2 (enExample) |
| EP (1) | EP3190888B1 (enExample) |
| JP (1) | JP2017528520A (enExample) |
| KR (1) | KR20170047341A (enExample) |
| CN (1) | CN107105655A (enExample) |
| AU (2) | AU2015308709B2 (enExample) |
| BR (1) | BR112017004134A2 (enExample) |
| CA (1) | CA2959505A1 (enExample) |
| EA (1) | EA201790408A1 (enExample) |
| ES (1) | ES2818107T3 (enExample) |
| IL (1) | IL250804A0 (enExample) |
| MX (1) | MX2017002705A (enExample) |
| SG (1) | SG11201701580XA (enExample) |
| WO (1) | WO2016033460A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107074817B (zh) | 2014-08-29 | 2023-12-15 | Chdi基金会股份有限公司 | 用于成像亨廷顿蛋白的探针 |
| CA2959533C (en) | 2014-08-29 | 2023-03-07 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| HRP20211778T1 (hr) | 2014-08-29 | 2022-03-18 | Chdi Foundation, Inc. | Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina |
| AU2016315648B2 (en) | 2015-08-28 | 2021-04-01 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| CN106632002A (zh) * | 2016-09-28 | 2017-05-10 | 贵州大学 | 一种依托考昔及其对照品5‑氯‑3‑(4‑(甲基磺酰基)苯基)‑2,3‑联吡啶的制备工艺 |
| GB201617339D0 (en) | 2016-10-12 | 2016-11-23 | Lytix Biopharma As | Therapeutic compounds |
| CN108178764A (zh) * | 2018-01-09 | 2018-06-19 | 天津科技大学 | 呋喃并[2,3-b]吡啶类化合物及无金属催化的合成方法 |
| WO2020176424A1 (en) | 2019-02-25 | 2020-09-03 | Chdi Foundation, Inc. | Compounds for targeting mutant huntingtin protein and uses thereof |
| JP2023536886A (ja) * | 2020-08-06 | 2023-08-30 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | ハンチンチンタンパク質をイメージングするためのヘテロビアリール化合物及びイメージング剤 |
| IL307507A (en) * | 2021-04-08 | 2023-12-01 | Chdi Foundation Inc | Isoindolinone compounds and imaging agents for imaging HUNTINGTIN protein |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1367836A (en) * | 1918-04-29 | 1921-02-08 | Int Precipitation Co | Process for obtaining chlorids of potassium or other metals |
| US3985755A (en) * | 1972-06-02 | 1976-10-12 | E. R. Squibb & Sons, Inc. | Pyridine containing isothiocyanobenzoxazoles |
| FR2524468B1 (fr) * | 1982-04-06 | 1985-10-18 | Sandoz Sa | Nouveaux derives condenses du thiophene, leur preparation et leur utilisation comme azurants optiques |
| JPS60146877A (ja) * | 1984-01-11 | 1985-08-02 | Chisso Corp | ２―置換―６―（５―置換―２―ピリミジニル）ナフタリン |
| JPH11171886A (ja) * | 1997-12-08 | 1999-06-29 | Mitsui Chem Inc | アミジンまたはグアニジンを側鎖にもつピロリルベンズイミダゾール誘導体 |
| HUP0402640A3 (en) | 2001-12-20 | 2012-09-28 | Wyeth Corp | Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands, process for their preparation and pharmaceutical compositions thereof |
| RU2440995C2 (ru) * | 2003-03-14 | 2012-01-27 | Юнивесити Оф Питсбэг | Производные бензотиазола, фармацевтическая композиция, обладающая свойством связывать амилоид, и способ детекции отложений амилоида у млекопитающего |
| CA2438032C (en) | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
| US20070053831A1 (en) | 2003-05-20 | 2007-03-08 | Barrio Jorge R | Methods for binding agents to b-amyloid plaques |
| AU2003304416A1 (en) * | 2003-08-13 | 2005-03-07 | Bf Research Institute, Inc. | Probe for disease with amyloid deposit, amyloid-staining agent, remedy and preventive for disease with amyloid deposit and diagnostic probe and staining agent for neurofibril change |
| US20100209345A1 (en) | 2006-08-24 | 2010-08-19 | Australian Nuclear Science & Technology Organisation | Fluorinated Ligands for Targeting Peripheral Benzodiazepine Receptors |
| US7858803B2 (en) * | 2007-04-27 | 2010-12-28 | The General Hospital Corporation | Imaging tracers for early detection and treatment of amyloid plaques caused by Alzheimer's disease and related disorders |
| KR101469275B1 (ko) | 2007-06-01 | 2014-12-08 | 재단법인서울대학교산학협력재단 | 베타아밀로이드 침착의 영상화를 위한 헤테로사이클릭 인덴계열의 유도체 및 그의 방사성 동위원소 표지화합물 |
| US20090123373A1 (en) | 2007-11-05 | 2009-05-14 | Yanming Wang | Amyloid-imaging agents |
| US8153813B2 (en) * | 2007-12-20 | 2012-04-10 | Abbott Laboratories | Benzothiazole and benzooxazole derivatives and methods of use |
| WO2009146388A1 (en) * | 2008-05-28 | 2009-12-03 | The Trustees Of Columbia University In The City Of New York | Voxel-based methods for assessing subjects using positron emission tomography |
| JP2011524864A (ja) | 2008-05-30 | 2011-09-08 | メルク・シャープ・エンド・ドーム・コーポレイション | 新規な置換されたアザベンゾオキサゾール |
| US20110212031A1 (en) | 2008-10-31 | 2011-09-01 | Cyrille Sur | Novel substituted azabenzoxazoles |
| US8691187B2 (en) | 2009-03-23 | 2014-04-08 | Eli Lilly And Company | Imaging agents for detecting neurological disorders |
| GB0905664D0 (en) | 2009-04-02 | 2009-05-13 | Summit Corp Plc | Compounds for treatment of duchenne muscular dystrophy |
| HUE027964T2 (en) | 2009-04-02 | 2016-11-28 | Fund Centro Nac De Investig Oncologicas Carlos Iii | Imidazo [2,1-b] [1,3,4] thiadiazole derivatives |
| WO2011045415A2 (en) | 2009-10-15 | 2011-04-21 | Guerbet | New imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases |
| JP2011168515A (ja) | 2010-02-17 | 2011-09-01 | Kowa Co | エリスロポエチン産生促進作用を有する２−アリールベンゾオキサゾール化合物 |
| CN107074817B (zh) | 2014-08-29 | 2023-12-15 | Chdi基金会股份有限公司 | 用于成像亨廷顿蛋白的探针 |
| CA2959533C (en) | 2014-08-29 | 2023-03-07 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| HRP20211778T1 (hr) | 2014-08-29 | 2022-03-18 | Chdi Foundation, Inc. | Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina |
| AU2016315648B2 (en) | 2015-08-28 | 2021-04-01 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
-
2015
- 2015-08-28 BR BR112017004134A patent/BR112017004134A2/pt not_active Application Discontinuation
- 2015-08-28 ES ES15836157T patent/ES2818107T3/es active Active
- 2015-08-28 KR KR1020177008352A patent/KR20170047341A/ko not_active Ceased
- 2015-08-28 AU AU2015308709A patent/AU2015308709B2/en active Active
- 2015-08-28 WO PCT/US2015/047427 patent/WO2016033460A1/en not_active Ceased
- 2015-08-28 EA EA201790408A patent/EA201790408A1/ru unknown
- 2015-08-28 CN CN201580058281.9A patent/CN107105655A/zh active Pending
- 2015-08-28 MX MX2017002705A patent/MX2017002705A/es unknown
- 2015-08-28 SG SG11201701580XA patent/SG11201701580XA/en unknown
- 2015-08-28 EP EP15836157.6A patent/EP3190888B1/en active Active
- 2015-08-28 CA CA2959505A patent/CA2959505A1/en not_active Abandoned
- 2015-08-28 JP JP2017530972A patent/JP2017528520A/ja not_active Ceased
- 2015-08-28 US US15/507,217 patent/US10907197B2/en active Active
-
2017
- 2017-02-27 IL IL250804A patent/IL250804A0/en unknown
-
2020
- 2020-03-30 AU AU2020202226A patent/AU2020202226A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2015308709A1 (en) | 2017-03-23 |
| EA201790408A1 (ru) | 2017-09-29 |
| EP3190888B1 (en) | 2020-06-10 |
| WO2016033460A1 (en) | 2016-03-03 |
| KR20170047341A (ko) | 2017-05-04 |
| MX2017002705A (es) | 2017-12-20 |
| BR112017004134A2 (pt) | 2017-12-12 |
| JP2017528520A (ja) | 2017-09-28 |
| CN107105655A (zh) | 2017-08-29 |
| CA2959505A1 (en) | 2016-03-03 |
| EP3190888A1 (en) | 2017-07-19 |
| AU2020202226A1 (en) | 2020-04-16 |
| US10907197B2 (en) | 2021-02-02 |
| ES2818107T3 (es) | 2021-04-09 |
| AU2015308709B2 (en) | 2020-01-02 |
| US20170292150A1 (en) | 2017-10-12 |
| SG11201701580XA (en) | 2017-03-30 |
| EP3190888A4 (en) | 2018-05-09 |
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