IL25056A - Process for the manufacture of benzodiazepine derivatives - Google Patents

Process for the manufacture of benzodiazepine derivatives

Info

Publication number
IL25056A
IL25056A IL25056A IL2505666A IL25056A IL 25056 A IL25056 A IL 25056A IL 25056 A IL25056 A IL 25056A IL 2505666 A IL2505666 A IL 2505666A IL 25056 A IL25056 A IL 25056A
Authority
IL
Israel
Prior art keywords
process according
formula
compounds
general formula
compound
Prior art date
Application number
IL25056A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL25056A publication Critical patent/IL25056A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL25056A 1965-02-08 1966-01-28 Process for the manufacture of benzodiazepine derivatives IL25056A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43117465A 1965-02-08 1965-02-08
US519017A US3405123A (en) 1965-02-08 1966-01-06 Process for preparing 1, 4-benzodiazepin-2-ones

Publications (1)

Publication Number Publication Date
IL25056A true IL25056A (en) 1969-11-12

Family

ID=27028912

Family Applications (1)

Application Number Title Priority Date Filing Date
IL25056A IL25056A (en) 1965-02-08 1966-01-28 Process for the manufacture of benzodiazepine derivatives

Country Status (11)

Country Link
US (1) US3405123A (de)
BE (1) BE676046A (de)
BR (1) BR6676844D0 (de)
CH (1) CH464944A (de)
DE (2) DE1695157A1 (de)
DK (2) DK129925B (de)
GB (1) GB1081946A (de)
IL (1) IL25056A (de)
NL (2) NL6601273A (de)
SE (2) SE371437B (de)
YU (1) YU33951B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005021005A2 (en) * 2003-08-28 2005-03-10 Ranbaxy Laboratories Limited Process for the preparation of 1,4-benzodiazepine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3247187A (en) * 1963-07-10 1966-04-19 Hoffmann La Roche Oxidation of 1, 4-benzodiazepines to 1, 4-benzodiazepin-2-ones

Also Published As

Publication number Publication date
DK129925C (de) 1975-05-20
US3405123A (en) 1968-10-08
CH464944A (de) 1968-11-15
YU165370A (en) 1978-02-28
NL6601273A (de) 1966-08-09
GB1081946A (en) 1967-09-06
BR6676844D0 (pt) 1973-12-26
SE334619B (de) 1971-05-03
NL7000509A (de) 1970-03-23
DE1695157A1 (de) 1970-12-17
BE676046A (de) 1966-08-04
DK129925B (da) 1974-12-02
DE1568742A1 (de) 1970-04-02
DK124949B (da) 1972-12-11
YU33951B (en) 1978-09-08
SE371437B (de) 1974-11-18

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