IL249058B2 - Improved forms of selective pi3k delta inhibitors for use in pharmaceutical formulations - Google Patents
Improved forms of selective pi3k delta inhibitors for use in pharmaceutical formulationsInfo
- Publication number
- IL249058B2 IL249058B2 IL249058A IL24905816A IL249058B2 IL 249058 B2 IL249058 B2 IL 249058B2 IL 249058 A IL249058 A IL 249058A IL 24905816 A IL24905816 A IL 24905816A IL 249058 B2 IL249058 B2 IL 249058B2
- Authority
- IL
- Israel
- Prior art keywords
- salt
- disease
- lymphoma
- tgr
- disorder
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2596CH2014 | 2014-05-27 | ||
| IN2597CH2014 | 2014-05-27 | ||
| PCT/IB2015/053940 WO2015181728A1 (en) | 2014-05-27 | 2015-05-26 | Improved forms of a pi3k delta selective inhibitor for use in pharmaceutical formulations |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL249058A0 IL249058A0 (en) | 2017-01-31 |
| IL249058B IL249058B (en) | 2022-11-01 |
| IL249058B2 true IL249058B2 (en) | 2023-03-01 |
Family
ID=53499042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL249058A IL249058B2 (en) | 2014-05-27 | 2016-11-20 | Improved forms of selective pi3k delta inhibitors for use in pharmaceutical formulations |
Country Status (22)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3149000T (lt) * | 2014-05-27 | 2021-09-10 | Rhizen Pharmaceuticals S.A. | Pi3k delta selektyvaus inhibitoriaus kristalinės tozilato druskos panaudojimas farmacinėse kompozicijose |
| AU2017268839A1 (en) | 2016-05-27 | 2018-11-29 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combination of anti-CD20 antibody, P13 kinase-delta selective inhibitor, and BTK inhibitor to treat B-cell proliferative disorders |
| JP2019526595A (ja) | 2016-09-09 | 2019-09-19 | ティージー セラピューティクス，インコーポレイテッド | 血液癌を治療するための抗ｃｄ２０抗体、ｐｉ３キナーゼ−デルタ阻害剤および抗ｐｄ−１抗体または抗ｐｄ−ｌ１抗体の組み合わせ |
| WO2021009509A1 (en) | 2019-07-15 | 2021-01-21 | Johnson Matthey Public Limited Company | Amorphous umbralisib monotosylate |
| WO2022104150A1 (en) | 2020-11-12 | 2022-05-19 | Tg Therapeutics, Inc. | Triple combination to treat b-cell malignancies |
| US11814439B1 (en) | 2022-06-01 | 2023-11-14 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11965032B1 (en) | 2022-06-01 | 2024-04-23 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11807689B1 (en) | 2022-06-01 | 2023-11-07 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11884740B1 (en) | 2022-06-01 | 2024-01-30 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014006572A1 (en) * | 2012-07-04 | 2014-01-09 | Rhizen Pharmaceuticals Sa | Selective pi3k delta inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3029041T1 (sl) * | 2000-04-25 | 2020-08-31 | Icos Corporation | Inhibitorji humane delta fosfatidil-inozitol 3-kinaze |
| WO2004056312A2 (en) | 2002-12-16 | 2004-07-08 | Genentech, Inc. | Immunoglobulin variants and uses thereof |
| US20050043239A1 (en) | 2003-08-14 | 2005-02-24 | Jason Douangpanya | Methods of inhibiting immune responses stimulated by an endogenous factor |
| EP2355828B1 (en) | 2008-11-13 | 2018-05-30 | Gilead Calistoga LLC | Therapies for hematologic malignancies |
| EP2411391A1 (en) | 2009-03-24 | 2012-02-01 | Gilead Calistoga LLC | Atropisomers of2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
| CA2759724A1 (en) | 2009-04-20 | 2010-10-28 | Calistoga Pharmaceuticals, Inc. | Methods of treatment for solid tumors |
| LT3149000T (lt) * | 2014-05-27 | 2021-09-10 | Rhizen Pharmaceuticals S.A. | Pi3k delta selektyvaus inhibitoriaus kristalinės tozilato druskos panaudojimas farmacinėse kompozicijose |
-
2015
- 2015-05-26 LT LTEPPCT/IB2015/053940T patent/LT3149000T/lt unknown
- 2015-05-26 CN CN202010471226.5A patent/CN111635406A/zh active Pending
- 2015-05-26 PT PT157335324T patent/PT3149000T/pt unknown
- 2015-05-26 CA CA2949932A patent/CA2949932C/en active Active
- 2015-05-26 JP JP2016569636A patent/JP6987501B2/ja not_active Expired - Fee Related
- 2015-05-26 AU AU2015265542A patent/AU2015265542B2/en not_active Ceased
- 2015-05-26 PL PL15733532T patent/PL3149000T3/pl unknown
- 2015-05-26 EP EP15733532.4A patent/EP3149000B1/en active Active
- 2015-05-26 HU HUE15733532A patent/HUE054916T2/hu unknown
- 2015-05-26 EP EP21182208.5A patent/EP3971188A1/en not_active Withdrawn
- 2015-05-26 HR HRP20211151TT patent/HRP20211151T1/hr unknown
- 2015-05-26 BR BR112016027674A patent/BR112016027674A2/pt not_active Application Discontinuation
- 2015-05-26 SM SM20210532T patent/SMT202100532T1/it unknown
- 2015-05-26 EA EA201692255A patent/EA032506B1/ru unknown
- 2015-05-26 US US15/313,454 patent/US9969740B2/en active Active
- 2015-05-26 ES ES15733532T patent/ES2880999T3/es active Active
- 2015-05-26 WO PCT/IB2015/053940 patent/WO2015181728A1/en not_active Ceased
- 2015-05-26 SI SI201531656T patent/SI3149000T1/sl unknown
- 2015-05-26 DK DK15733532.4T patent/DK3149000T3/da active
- 2015-05-26 RS RS20210920A patent/RS62136B1/sr unknown
- 2015-05-26 CN CN201580034288.7A patent/CN106661030B/zh not_active Expired - Fee Related
- 2015-05-26 KR KR1020167036318A patent/KR20170007480A/ko not_active Ceased
-
2016
- 2016-11-20 IL IL249058A patent/IL249058B2/en unknown
-
2018
- 2018-04-11 US US15/950,606 patent/US10414773B2/en active Active
-
2019
- 2019-08-30 US US16/557,091 patent/US10947244B2/en not_active Expired - Fee Related
-
2020
- 2020-05-20 JP JP2020088147A patent/JP2020122022A/ja active Pending
- 2020-12-23 US US17/247,806 patent/US20210269446A1/en not_active Abandoned
-
2021
- 2021-07-21 CY CY20211100652T patent/CY1124316T1/el unknown
-
2022
- 2022-04-05 JP JP2022062937A patent/JP2022082680A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014006572A1 (en) * | 2012-07-04 | 2014-01-09 | Rhizen Pharmaceuticals Sa | Selective pi3k delta inhibitors |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10414773B2 (en) | Forms of a PI3K delta selective inhibitor for use in pharmaceutical formulations | |
| CN112165958A (zh) | 调制激酶的化合物的制剂 | |
| JP2024533423A (ja) | 薬学的組成物およびその使用 | |
| CN109988104B (zh) | 山奈酚与异烟酰胺共晶物及制备方法和其药物组合物与用途 | |
| JP2020500845A (ja) | 砒素組成物 | |
| CN106659761A (zh) | 初级癌症疗法后使用的含硼蛋白酶体抑制剂 | |
| CN111840289A (zh) | 用于治疗骨巨细胞瘤的喹啉类化合物或其药学上可接受的盐 | |
| CN101912399B (zh) | 放射线治疗增强剂 | |
| KR20250085748A (ko) | 약학적 조성물 및 이의 용도 | |
| HK1236026B (en) | Crystalline tosylate salt of a pi3k delta selective inhibitor for use in pharmaceutical formulations | |
| CA3218977A1 (en) | A plurality of tasquinimod particles and use thereof | |
| EA042667B1 (ru) | Улучшенные формы селективного ингибитора pi3k-дельта для применения в фармацевтических препаратах | |
| KR20230026415A (ko) | 경구 제제 및 이의 용도 | |
| WO2019130194A1 (en) | Novel drug products of picropodophyllin | |
| EA040951B1 (ru) | Лекарственные формы цис-4-[2-{[(3s,4r)-3-фтороксан-4-ил]амино}-8-(2,4,6-трихлоранилино)-9н-пурин-9-ил]-1-метилциклогексан-1-карбоксамида и их применение в способе лечения рака | |
| HK1118704B (en) | Radiotherapy enhancer | |
| HK1148204B (en) | Radiotherapy enhancer | |
| HK1118807B (en) | Potentiator for radiation therapy comprising pyridine derivative as active ingredient |