IL240804B - Converted pyridine and pyrazine compounds as 4pde inhibitors - Google Patents

Converted pyridine and pyrazine compounds as 4pde inhibitors

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Publication number
IL240804B
IL240804B IL24080415A IL24080415A IL240804B IL 240804 B IL240804 B IL 240804B IL 24080415 A IL24080415 A IL 24080415A IL 24080415 A IL24080415 A IL 24080415A IL 240804 B IL240804 B IL 240804B
Authority
IL
Israel
Prior art keywords
substituted pyridine
pde4 inhibitors
pyrazine compounds
pyrazine
compounds
Prior art date
Application number
IL24080415A
Other languages
English (en)
Hebrew (he)
Other versions
IL240804A0 (en
Original Assignee
Dart Neuroscience Cayman Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dart Neuroscience Cayman Ltd filed Critical Dart Neuroscience Cayman Ltd
Publication of IL240804A0 publication Critical patent/IL240804A0/en
Publication of IL240804B publication Critical patent/IL240804B/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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