IL240206A0 - Preparations containing amorphous sulfasalazine and their uses - Google Patents
Preparations containing amorphous sulfasalazine and their usesInfo
- Publication number
- IL240206A0 IL240206A0 IL240206A IL24020615A IL240206A0 IL 240206 A0 IL240206 A0 IL 240206A0 IL 240206 A IL240206 A IL 240206A IL 24020615 A IL24020615 A IL 24020615A IL 240206 A0 IL240206 A0 IL 240206A0
- Authority
- IL
- Israel
- Prior art keywords
- compositions
- amorphous sulfasalazine
- sulfasalazine
- amorphous
- Prior art date
Links
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 title 1
- 229960001940 sulfasalazine Drugs 0.000 title 1
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361759933P | 2013-02-01 | 2013-02-01 | |
| US201361780340P | 2013-03-13 | 2013-03-13 | |
| PCT/US2014/014290 WO2014121137A2 (en) | 2013-02-01 | 2014-01-31 | Compositions and methods for the treatment of neurodegenerative and other diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL240206A0 true IL240206A0 (en) | 2015-09-24 |
Family
ID=50382538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL240206A IL240206A0 (en) | 2013-02-01 | 2015-07-29 | Preparations containing amorphous sulfasalazine and their uses |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US9597339B2 (OSRAM) |
| EP (1) | EP2950797B1 (OSRAM) |
| JP (2) | JP6328146B2 (OSRAM) |
| KR (1) | KR20150139830A (OSRAM) |
| CN (1) | CN105163735B (OSRAM) |
| AU (2) | AU2014212109B2 (OSRAM) |
| CA (1) | CA2899032A1 (OSRAM) |
| ES (1) | ES2752021T3 (OSRAM) |
| IL (1) | IL240206A0 (OSRAM) |
| WO (1) | WO2014121137A2 (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6328146B2 (ja) * | 2013-02-01 | 2018-05-23 | グリアロジクス・インコーポレイテッドGlialogix, Inc. | 神経変性およびその他の疾患の治療用組成物および方法 |
| KR102364840B1 (ko) | 2014-11-05 | 2022-02-18 | 삼성전자주식회사 | 신경세포의 탈수초화와 연관된 질환을 치료하기 위한 약학적 조성물 및 그를 이용하는 방법 |
| US20160199393A1 (en) * | 2015-01-08 | 2016-07-14 | China Medical University | Methods of treating brain ischemia or hypoxia |
| ES2650175B1 (es) * | 2016-04-15 | 2019-02-04 | Servicio Andaluz De Salud | Tratamiento de enfermedades neurodegenerativas |
| WO2017189504A1 (en) * | 2016-04-26 | 2017-11-02 | Saint Louis University | Highly selective adenosine a3 receptor subtype agonsists for the prevention and treatment of neurodegenerative disorders |
| TW201818933A (zh) * | 2016-10-21 | 2018-06-01 | 美商吉利亞洛吉克斯公司 | 用於神經退化性及其他疾病的治療之組成物和方法 |
| US10473672B2 (en) * | 2017-02-09 | 2019-11-12 | Kaohsiung Chang Gung Memorial Hospital | Methods for diagnosing and treating Alzheimers disease using G72 protein and SLC7A11 mRNA as biomarkers |
| US20230210871A1 (en) * | 2017-10-12 | 2023-07-06 | The Limited Company Research And Development Company "Medbiopharm" | Use of sulfasalazine as an inhibitor of the formation of advanced glycation end products |
| WO2019102992A1 (ja) * | 2017-11-21 | 2019-05-31 | 積水化学工業株式会社 | 皮膚外用剤 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2396145A (en) | 1940-12-14 | 1946-03-05 | Pharmscia Ab | Heterocyclic sulphonamido azo compounds |
| FR2608988B1 (fr) | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules |
| JPH10506406A (ja) | 1994-09-29 | 1998-06-23 | アンダリス、リミテッド | 治療用ビヒクルとしての噴霧乾燥させた微細粒子 |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| ITMI962356A1 (it) | 1996-11-13 | 1998-05-13 | Uni Degli Studi Di Brescia D I | Uso di composti derivati da molecole ad attivita' antinfiammatoria di tipo non steroideo per la prevenzione e il trattamento di |
| ES2236832T3 (es) | 1997-01-16 | 2005-07-16 | Massachusetts Institute Of Technology | Preparacion de particulas para inhalacion. |
| JP2002518432A (ja) | 1998-06-24 | 2002-06-25 | アドバンスト インハレーション リサーチ,インコーポレイテッド | 吸入器から放出される大多孔性粒子 |
| DK1107743T3 (da) | 1998-08-25 | 2007-10-22 | Advanced Inhalation Res Inc | Stabile, spraytörrede proteinformuleringer |
| US6586008B1 (en) | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
| KR100417623B1 (ko) | 2000-03-28 | 2004-02-05 | 주식회사 뉴로테크 | 뇌질환 예방 및 치료용 조성물 |
| CA2307278A1 (en) | 2000-04-28 | 2001-10-28 | University Of British Columbia | Use of n-heterocyclic substituted salicylic acids for inhibition of cellular uptake of cystine |
| BR0307515A (pt) | 2002-02-01 | 2004-12-07 | Pfizer Prod Inc | Método para fabricar dispersões de drogas amorfas sólidas secas por aspersão homogêneas usando bicos de pressão |
| JP4865989B2 (ja) | 2002-02-01 | 2012-02-01 | ベンド・リサーチ・インコーポレーテッド | 改良された噴霧乾燥装置を使用する均質な噴霧乾燥された固体の非晶質薬物分散物を製造する方法 |
| CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
| US20060045865A1 (en) | 2004-08-27 | 2006-03-02 | Spherics, Inc. | Controlled regional oral delivery |
| US8748445B2 (en) | 2004-10-27 | 2014-06-10 | The Uab Research Foundation | Methods for treating glioma |
| CN101291658B (zh) | 2005-08-31 | 2014-04-16 | 阿布拉科斯生物科学有限公司 | 用于制备稳定性增加的水难溶性药物的组合物和方法 |
| US20070053869A1 (en) | 2005-09-02 | 2007-03-08 | Yuichi Sugiyama | Formulation and method for enhancement of gastrointestinal absorption of pharmaceutical agents |
| GB0602123D0 (en) * | 2006-02-02 | 2006-03-15 | Novartis Ag | Organic compounds |
| PT1983984T (pt) | 2006-02-02 | 2018-06-14 | Novartis Ag | Tratamento da esclerosa tuberosa |
| US7964585B2 (en) | 2006-03-14 | 2011-06-21 | Case Western Reserve University | Composition and method of treating peripheral neuropathy |
| BRPI0716196A2 (pt) | 2006-08-31 | 2013-11-12 | Eurand Inc | Sistemas de distribuição de fármacos que compreendem soluções sólidas de fármacos fracamente básicos. |
| WO2008135828A2 (en) | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
| WO2009073215A1 (en) | 2007-12-06 | 2009-06-11 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
| BRPI0908340A2 (pt) * | 2008-02-28 | 2018-12-26 | Bial Portela & Ca Sa | composição farmacêutica para fármacos pouco solúveis |
| PT2113254E (pt) * | 2008-04-28 | 2012-11-26 | Txcell | Composições para o tratamento de um estado inflamatório auto-imune |
| TW201438738A (zh) | 2008-09-16 | 2014-10-16 | 建南德克公司 | 治療進展型多發性硬化症之方法 |
| EP2411137B1 (en) | 2009-03-27 | 2016-09-07 | Bend Research, Inc. | Spray-drying process |
| PT2611530T (pt) | 2010-09-03 | 2019-05-09 | Bend Res Inc | Aparelho de secagem por pulverização e métodos de utilização do mesmo |
| WO2012031129A2 (en) | 2010-09-03 | 2012-03-08 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
| HK1204970A1 (en) | 2012-01-31 | 2015-12-11 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
| JP6328146B2 (ja) * | 2013-02-01 | 2018-05-23 | グリアロジクス・インコーポレイテッドGlialogix, Inc. | 神経変性およびその他の疾患の治療用組成物および方法 |
| ES3041833T3 (en) | 2013-12-31 | 2025-11-14 | Ascendia Pharmaceuticals Llc | Pharmaceutical compositions for poorly water-soluble compounds |
-
2014
- 2014-01-31 JP JP2015556185A patent/JP6328146B2/ja not_active Expired - Fee Related
- 2014-01-31 EP EP14712798.9A patent/EP2950797B1/en active Active
- 2014-01-31 CA CA2899032A patent/CA2899032A1/en not_active Abandoned
- 2014-01-31 ES ES14712798T patent/ES2752021T3/es active Active
- 2014-01-31 AU AU2014212109A patent/AU2014212109B2/en not_active Ceased
- 2014-01-31 CN CN201480019892.8A patent/CN105163735B/zh not_active Expired - Fee Related
- 2014-01-31 US US14/170,405 patent/US9597339B2/en not_active Expired - Fee Related
- 2014-01-31 KR KR1020157023718A patent/KR20150139830A/ko not_active Withdrawn
- 2014-01-31 WO PCT/US2014/014290 patent/WO2014121137A2/en not_active Ceased
-
2015
- 2015-07-29 IL IL240206A patent/IL240206A0/en unknown
-
2016
- 2016-11-30 US US15/365,843 patent/US9980978B2/en not_active Expired - Fee Related
- 2016-11-30 US US15/365,835 patent/US9974798B2/en not_active Expired - Fee Related
-
2017
- 2017-02-10 US US15/430,294 patent/US9918997B2/en not_active Expired - Fee Related
-
2018
- 2018-04-17 JP JP2018079284A patent/JP2018123159A/ja active Pending
- 2018-04-17 US US15/955,020 patent/US10398713B2/en not_active Expired - Fee Related
- 2018-08-28 AU AU2018222921A patent/AU2018222921A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014121137A2 (en) | 2014-08-07 |
| US9980978B2 (en) | 2018-05-29 |
| ES2752021T3 (es) | 2020-04-02 |
| US9918997B2 (en) | 2018-03-20 |
| US20170079990A1 (en) | 2017-03-23 |
| US9974798B2 (en) | 2018-05-22 |
| KR20150139830A (ko) | 2015-12-14 |
| AU2018222921A1 (en) | 2018-09-20 |
| US9597339B2 (en) | 2017-03-21 |
| CA2899032A1 (en) | 2014-08-07 |
| JP2016507526A (ja) | 2016-03-10 |
| WO2014121137A3 (en) | 2014-11-27 |
| EP2950797B1 (en) | 2019-09-11 |
| AU2014212109A1 (en) | 2015-08-06 |
| US20190015431A1 (en) | 2019-01-17 |
| US20170165279A1 (en) | 2017-06-15 |
| US20140221321A1 (en) | 2014-08-07 |
| EP2950797A2 (en) | 2015-12-09 |
| CN105163735B (zh) | 2018-12-11 |
| CN105163735A (zh) | 2015-12-16 |
| US10398713B2 (en) | 2019-09-03 |
| JP6328146B2 (ja) | 2018-05-23 |
| US20170079991A1 (en) | 2017-03-23 |
| AU2014212109B2 (en) | 2018-05-31 |
| JP2018123159A (ja) | 2018-08-09 |
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