IL240164A0 - spiro-lactam modulators of the NMDA receptor and their uses - Google Patents

spiro-lactam modulators of the NMDA receptor and their uses

Info

Publication number
IL240164A0
IL240164A0 IL240164A IL24016415A IL240164A0 IL 240164 A0 IL240164 A0 IL 240164A0 IL 240164 A IL240164 A IL 240164A IL 24016415 A IL24016415 A IL 24016415A IL 240164 A0 IL240164 A0 IL 240164A0
Authority
IL
Israel
Prior art keywords
spiro
nmda receptor
receptor modulators
lactam nmda
lactam
Prior art date
Application number
IL240164A
Other languages
English (en)
Hebrew (he)
Original Assignee
Naurex Inc
John A Lowe Iii
Amin Khan M
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50071824&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL240164(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Naurex Inc, John A Lowe Iii, Amin Khan M filed Critical Naurex Inc
Publication of IL240164A0 publication Critical patent/IL240164A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL240164A 2013-01-29 2015-07-27 spiro-lactam modulators of the NMDA receptor and their uses IL240164A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361757942P 2013-01-29 2013-01-29
PCT/US2014/013639 WO2014120800A1 (en) 2013-01-29 2014-01-29 Spiro-lactam nmda receptor modulators and uses thereof

Publications (1)

Publication Number Publication Date
IL240164A0 true IL240164A0 (en) 2015-09-24

Family

ID=50071824

Family Applications (1)

Application Number Title Priority Date Filing Date
IL240164A IL240164A0 (en) 2013-01-29 2015-07-27 spiro-lactam modulators of the NMDA receptor and their uses

Country Status (16)

Country Link
US (2) US9708335B2 (show.php)
EP (1) EP2951185B1 (show.php)
JP (1) JP2016506962A (show.php)
KR (1) KR20150110784A (show.php)
CN (1) CN105308049A (show.php)
AU (1) AU2014212501A1 (show.php)
BR (1) BR112015018094A2 (show.php)
CA (1) CA2899191A1 (show.php)
EA (1) EA201591405A1 (show.php)
ES (1) ES2618421T3 (show.php)
IL (1) IL240164A0 (show.php)
MX (1) MX2015009785A (show.php)
PE (1) PE20151436A1 (show.php)
PH (1) PH12015501598A1 (show.php)
SG (1) SG11201505862TA (show.php)
WO (1) WO2014120800A1 (show.php)

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DK2951183T3 (da) 2013-01-29 2019-06-03 Aptinyx Inc Spiro-lactam-nmda-receptormodulatorer og anvendelser heraf
ES2618421T3 (es) 2013-01-29 2017-06-21 Aptinyx Inc. Moduladores espiro-lactama del receptor NMDA y usos de los mismos
EA031905B1 (ru) * 2013-01-29 2019-03-29 Аптиникс Инк. Спиролактамные модуляторы рецептора nmda и их применение
JP2017516836A (ja) 2014-06-04 2017-06-22 リューゲン ホールディングス （ケイマン） リミテッド Ｎｒ２ｂｎｍｄａ受容体アンタゴニストとしてのジフルオロエチルピリジン誘導体
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WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
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AU2017305240B2 (en) 2016-08-01 2021-12-09 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
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EA201990424A1 (ru) * 2016-08-01 2019-08-30 Аптиникс Инк. Спиролактамовые модуляторы nmda-рецептора и их применение
SG11201900546UA (en) * 2016-08-01 2019-02-27 Aptinyx Inc Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof
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US11578072B2 (en) * 2018-01-31 2023-02-14 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
SG11202007251XA (en) * 2018-01-31 2020-08-28 Aptinyx Inc Spiro-lactam nmda receptor modulators and uses thereof
WO2019152696A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
WO2019152685A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and methods of using same
WO2019152688A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
JP7667097B2 (ja) 2019-06-14 2025-04-22 ヤンセン ファーマシューティカ エヌ．ベー． 置換ピラゾロ－ピリジンアミド及びｇｌｕｎ２ｂ受容体調節因子としてのその使用
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US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy
CN111018746A (zh) * 2019-12-16 2020-04-17 山东金城柯瑞化学有限公司 一种氨曲南主环合成中间体n-苄氧羰基-l-苏氨酸酰胺的合成方法

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Also Published As

Publication number Publication date
CN105308049A (zh) 2016-02-03
KR20150110784A (ko) 2015-10-02
PH12015501598A1 (en) 2015-10-19
BR112015018094A2 (pt) 2017-07-18
AU2014212501A1 (en) 2015-07-30
EA201591405A1 (ru) 2017-05-31
US10316041B2 (en) 2019-06-11
CA2899191A1 (en) 2014-08-07
ES2618421T3 (es) 2017-06-21
PE20151436A1 (es) 2015-10-10
US20180127430A1 (en) 2018-05-10
US20150368254A1 (en) 2015-12-24
US9708335B2 (en) 2017-07-18
EP2951185B1 (en) 2016-12-21
WO2014120800A1 (en) 2014-08-07
JP2016506962A (ja) 2016-03-07
SG11201505862TA (en) 2015-08-28
EP2951185A1 (en) 2015-12-09
MX2015009785A (es) 2016-04-04

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