IL240162B - spiro-lactam modulators of the NMDA receptor and their uses - Google Patents

spiro-lactam modulators of the NMDA receptor and their uses

Info

Publication number
IL240162B
IL240162B IL240162A IL24016215A IL240162B IL 240162 B IL240162 B IL 240162B IL 240162 A IL240162 A IL 240162A IL 24016215 A IL24016215 A IL 24016215A IL 240162 B IL240162 B IL 240162B
Authority
IL
Israel
Prior art keywords
spiro
nmda receptor
receptor modulators
lactam nmda
lactam
Prior art date
Application number
IL240162A
Other languages
English (en)
Hebrew (he)
Other versions
IL240162A0 (en
Inventor
A Lowe John Iii
Amin Khan M
Original Assignee
A Lowe John Iii
Amin Khan M
Aptinyx Inc
Naurex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A Lowe John Iii, Amin Khan M, Aptinyx Inc, Naurex Inc filed Critical A Lowe John Iii
Publication of IL240162A0 publication Critical patent/IL240162A0/en
Publication of IL240162B publication Critical patent/IL240162B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL240162A 2013-01-29 2015-07-27 spiro-lactam modulators of the NMDA receptor and their uses IL240162B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361757920P 2013-01-29 2013-01-29
PCT/US2014/013621 WO2014120784A1 (en) 2013-01-29 2014-01-29 Spiro-lactam nmda receptor modulators and uses thereof

Publications (2)

Publication Number Publication Date
IL240162A0 IL240162A0 (en) 2015-09-24
IL240162B true IL240162B (en) 2020-08-31

Family

ID=50069346

Family Applications (1)

Application Number Title Priority Date Filing Date
IL240162A IL240162B (en) 2013-01-29 2015-07-27 spiro-lactam modulators of the NMDA receptor and their uses

Country Status (16)

Country Link
US (5) US9828384B2 (enExample)
EP (1) EP2951182B1 (enExample)
JP (1) JP6531042B2 (enExample)
KR (1) KR102410989B1 (enExample)
CN (1) CN105408336B (enExample)
AU (1) AU2014212485C1 (enExample)
BR (1) BR112015018089B1 (enExample)
CA (1) CA2898774C (enExample)
CL (1) CL2015002122A1 (enExample)
EA (1) EA032153B1 (enExample)
IL (1) IL240162B (enExample)
MX (1) MX375286B (enExample)
PE (1) PE20151427A1 (enExample)
PH (1) PH12015501596B1 (enExample)
SG (1) SG11201505942YA (enExample)
WO (1) WO2014120784A1 (enExample)

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BRPI0918868B8 (pt) 2008-09-18 2021-05-25 Naurex Inc compostos moduladores do receptor de nmda e composições compreendendo os mesmos
KR20150110784A (ko) 2013-01-29 2015-10-02 노렉스, 인크. 스피로-락탐 nmda 수용체 조절인자 및 그의 용도
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SG11201900558RA (en) 2016-08-01 2019-02-27 Aptinyx Inc Spiro-lactam nmda receptor modulators and uses thereof
CA3089561A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
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WO2019152681A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof
CN112218866A (zh) * 2018-01-31 2021-01-12 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
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Also Published As

Publication number Publication date
PH12015501596B1 (en) 2023-12-06
CN105408336A (zh) 2016-03-16
BR112015018089B1 (pt) 2022-09-20
KR20150110788A (ko) 2015-10-02
BR112015018089A2 (pt) 2017-07-18
EA032153B1 (ru) 2019-04-30
US20150368252A1 (en) 2015-12-24
CL2015002122A1 (es) 2015-12-18
JP2016506959A (ja) 2016-03-07
AU2014212485C1 (en) 2018-10-25
JP6531042B2 (ja) 2019-06-12
US9828384B2 (en) 2017-11-28
MX2015009772A (es) 2016-05-31
WO2014120784A1 (en) 2014-08-07
HK1218418A1 (en) 2017-02-17
SG11201505942YA (en) 2015-08-28
US20180244680A1 (en) 2018-08-30
PH12015501596A1 (en) 2015-10-19
CA2898774C (en) 2021-07-13
EP2951182A1 (en) 2015-12-09
EP2951182B1 (en) 2020-03-18
IL240162A0 (en) 2015-09-24
EA201591402A1 (ru) 2015-12-30
PE20151427A1 (es) 2015-10-10
MX375286B (es) 2025-03-06
AU2014212485B2 (en) 2018-04-19
AU2014212485A1 (en) 2015-07-30
KR102410989B1 (ko) 2022-06-17
US20180179218A1 (en) 2018-06-28
US20210155632A1 (en) 2021-05-27
US20180215767A1 (en) 2018-08-02
CN105408336B (zh) 2018-06-26
CA2898774A1 (en) 2014-08-07
NZ709872A (en) 2020-09-25

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