IL236198A0 - Dry powder for inhalation preparation containing salmatrol zinafoate, fluticasone propionate and tiotropium bromide, and its production method - Google Patents
Dry powder for inhalation preparation containing salmatrol zinafoate, fluticasone propionate and tiotropium bromide, and its production methodInfo
- Publication number
- IL236198A0 IL236198A0 IL236198A IL23619814A IL236198A0 IL 236198 A0 IL236198 A0 IL 236198A0 IL 236198 A IL236198 A IL 236198A IL 23619814 A IL23619814 A IL 23619814A IL 236198 A0 IL236198 A0 IL 236198A0
- Authority
- IL
- Israel
- Prior art keywords
- inhslstion
- formulation
- dry powder
- fluticasone propionate
- tiotropium bromide
- Prior art date
Links
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 title 1
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 title 1
- 229960000289 fluticasone propionate Drugs 0.000 title 1
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000000843 powder Substances 0.000 title 1
- 229960005018 salmeterol xinafoate Drugs 0.000 title 1
- 229960000257 tiotropium bromide Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020120063665A KR20130140358A (ko) | 2012-06-14 | 2012-06-14 | 살메테롤 지나포산염, 플루티카손 프로피오네이트 및 티오트로피움 브로마이드를 포함하는 흡입 제형용 건조 분말 및 이의 제조방법 |
| PCT/KR2013/004880 WO2013187626A1 (en) | 2012-06-14 | 2013-06-03 | Dry powder for inhalation formulation comprising salmeterol xinafoate, fluticasone propionate and tiotropium bromide, and method for preparing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL236198A0 true IL236198A0 (en) | 2015-01-29 |
Family
ID=49758405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL236198A IL236198A0 (en) | 2012-06-14 | 2014-12-11 | Dry powder for inhalation preparation containing salmatrol zinafoate, fluticasone propionate and tiotropium bromide, and its production method |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9283232B2 (forum.php) |
| EP (1) | EP2861219A4 (forum.php) |
| JP (1) | JP2015519394A (forum.php) |
| KR (1) | KR20130140358A (forum.php) |
| CN (1) | CN104363895A (forum.php) |
| AU (1) | AU2013275113A1 (forum.php) |
| BR (1) | BR112014030910A2 (forum.php) |
| CA (1) | CA2876283A1 (forum.php) |
| HK (1) | HK1206602A1 (forum.php) |
| IL (1) | IL236198A0 (forum.php) |
| IN (1) | IN2014DN11257A (forum.php) |
| MX (1) | MX2014014755A (forum.php) |
| NZ (1) | NZ703788A (forum.php) |
| PH (1) | PH12014502746A1 (forum.php) |
| RU (1) | RU2015100905A (forum.php) |
| SG (1) | SG11201408292YA (forum.php) |
| TW (1) | TWI565481B (forum.php) |
| WO (1) | WO2013187626A1 (forum.php) |
| ZA (1) | ZA201500208B (forum.php) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2952510T3 (es) | 2014-06-30 | 2023-10-31 | Proveris Scient Corporation | Aparato de muestreo para determinar la cantidad y uniformidad de una dosis administrada de medicamento y métodos relacionados |
| KR20160038767A (ko) * | 2014-09-30 | 2016-04-07 | 한미약품 주식회사 | 복합 활성성분의 안정성이 개선된 흡입 제형용 건조분말 |
| MA41378A (fr) * | 2015-01-20 | 2017-11-28 | Teva Branded Pharmaceutical Prod R & D Inc | Inhalateur de poudre sèche comprenant du propionate de fluticasone et du xinafoate de salmétérol |
| KR20160117069A (ko) * | 2015-03-31 | 2016-10-10 | 한미약품 주식회사 | 복합 활성성분의 안정성이 개선된 흡입용 캡슐제 |
| KR102356120B1 (ko) * | 2015-05-01 | 2022-01-28 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 다중 약물 취성 매트릭스 조성물 |
| CA3016890A1 (en) * | 2016-03-09 | 2017-09-14 | Proveris Scientific Corporation | Methods for measuring dose content uniformity performance of inhaler and nasal devices |
| CN108066329B (zh) * | 2016-11-11 | 2021-11-16 | 江苏恒瑞医药股份有限公司 | 一种吸入用氟替卡松或其衍生物的微粒的制备方法 |
| EP3910324A1 (en) * | 2018-08-07 | 2021-11-17 | Norton (Waterford) Limited | Application of raman spectroscopy for the manufacture of inhalation powders |
| KR102696616B1 (ko) * | 2018-12-21 | 2024-08-20 | 한미약품 주식회사 | 흡입 제형용 건조 분말 및 이의 제조방법 |
| KR102330428B1 (ko) * | 2019-10-14 | 2021-11-24 | 한미약품 주식회사 | 흡입 제형용 건조 분말 및 이의 제조방법 |
| US20230293430A1 (en) * | 2020-06-26 | 2023-09-21 | Mylan Pharma Uk Limited | Formulations including 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide |
| CN115266987B (zh) * | 2022-07-31 | 2023-06-30 | 浙江知一药业有限责任公司 | 治疗呼吸系统疾病的药物组合物 |
| CN115792071B (zh) * | 2022-12-01 | 2025-02-18 | 南京联智医药科技有限公司 | 一种噻格溴铵中间体的有关物质分析方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9322014D0 (en) | 1993-10-26 | 1993-12-15 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| GB0003935D0 (en) * | 2000-02-08 | 2000-04-12 | King S College London | Formulation for dry powder inhaler |
| DE10130371A1 (de) | 2001-06-23 | 2003-01-02 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika |
| GB0312148D0 (en) | 2003-05-28 | 2003-07-02 | Aventis Pharma Ltd | Stabilized pharmaceutical products |
| SE527190C2 (sv) * | 2003-06-19 | 2006-01-17 | Microdrug Ag | Inhalatoranordning samt kombinerade doser av en beta2-agonist, ett antikolinergiskt medel och ett antiinflammatorisk steroid |
| GB0326632D0 (en) | 2003-11-14 | 2003-12-17 | Jagotec Ag | Dry powder formulations |
| EP2124915A2 (en) | 2007-02-19 | 2009-12-02 | Cipla Limited | Pharmaceutical combinations of at least two bronchodilators or of a bronchodilator with a corticosteroid |
| WO2009036243A1 (en) | 2007-09-12 | 2009-03-19 | Glaxo Group Limited | Novel combination of therapeutic agents |
| WO2010007447A1 (en) * | 2008-07-18 | 2010-01-21 | Prosonix Limited | Process for improving crystallinity |
| AU2009276498A1 (en) * | 2008-07-30 | 2010-02-04 | Stc.Unm | Formulations containing large-size carrier particles for dry powder inhalation aerosols |
| TR201000681A2 (tr) * | 2010-01-29 | 2011-08-22 | B�Lg�� Mahmut | İnhalasyon yoluyla alınan kuru toz formülasyonları. |
-
2012
- 2012-06-14 KR KR1020120063665A patent/KR20130140358A/ko not_active Ceased
-
2013
- 2013-06-03 CA CA2876283A patent/CA2876283A1/en not_active Abandoned
- 2013-06-03 US US14/402,548 patent/US9283232B2/en not_active Expired - Fee Related
- 2013-06-03 RU RU2015100905A patent/RU2015100905A/ru not_active Application Discontinuation
- 2013-06-03 WO PCT/KR2013/004880 patent/WO2013187626A1/en not_active Ceased
- 2013-06-03 EP EP13804439.1A patent/EP2861219A4/en not_active Withdrawn
- 2013-06-03 NZ NZ703788A patent/NZ703788A/en not_active IP Right Cessation
- 2013-06-03 SG SG11201408292YA patent/SG11201408292YA/en unknown
- 2013-06-03 MX MX2014014755A patent/MX2014014755A/es unknown
- 2013-06-03 CN CN201380030898.0A patent/CN104363895A/zh active Pending
- 2013-06-03 HK HK15107131.8A patent/HK1206602A1/xx unknown
- 2013-06-03 AU AU2013275113A patent/AU2013275113A1/en not_active Abandoned
- 2013-06-03 JP JP2015517171A patent/JP2015519394A/ja active Pending
- 2013-06-03 BR BR112014030910A patent/BR112014030910A2/pt not_active IP Right Cessation
- 2013-06-03 IN IN11257DEN2014 patent/IN2014DN11257A/en unknown
- 2013-06-13 TW TW102120909A patent/TWI565481B/zh not_active IP Right Cessation
-
2014
- 2014-12-09 PH PH12014502746A patent/PH12014502746A1/en unknown
- 2014-12-11 IL IL236198A patent/IL236198A0/en unknown
-
2015
- 2015-01-13 ZA ZA2015/00208A patent/ZA201500208B/en unknown
- 2015-06-22 US US14/746,225 patent/US9549936B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US9283232B2 (en) | 2016-03-15 |
| US20150157566A1 (en) | 2015-06-11 |
| TW201402154A (zh) | 2014-01-16 |
| PH12014502746B1 (en) | 2015-02-02 |
| HK1206602A1 (en) | 2016-01-15 |
| JP2015519394A (ja) | 2015-07-09 |
| WO2013187626A1 (en) | 2013-12-19 |
| AU2013275113A1 (en) | 2015-02-05 |
| ZA201500208B (en) | 2016-10-26 |
| TWI565481B (zh) | 2017-01-11 |
| RU2015100905A (ru) | 2016-08-10 |
| US9549936B2 (en) | 2017-01-24 |
| KR20130140358A (ko) | 2013-12-24 |
| US20150283151A1 (en) | 2015-10-08 |
| SG11201408292YA (en) | 2015-01-29 |
| PH12014502746A1 (en) | 2015-02-02 |
| EP2861219A1 (en) | 2015-04-22 |
| CN104363895A (zh) | 2015-02-18 |
| IN2014DN11257A (forum.php) | 2015-10-09 |
| BR112014030910A2 (pt) | 2017-06-27 |
| CA2876283A1 (en) | 2013-12-19 |
| NZ703788A (en) | 2016-10-28 |
| MX2014014755A (es) | 2015-02-24 |
| EP2861219A4 (en) | 2015-10-28 |
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