IL234886A - Troponin activators for myocardial muscle, the compositions containing them, and their use in drug production - Google Patents
Troponin activators for myocardial muscle, the compositions containing them, and their use in drug productionInfo
- Publication number
- IL234886A IL234886A IL234886A IL23488614A IL234886A IL 234886 A IL234886 A IL 234886A IL 234886 A IL234886 A IL 234886A IL 23488614 A IL23488614 A IL 23488614A IL 234886 A IL234886 A IL 234886A
- Authority
- IL
- Israel
- Prior art keywords
- medicaments
- compositions
- manufacture
- same
- skeletal muscle
- Prior art date
Links
- 239000012190 activator Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 210000002027 skeletal muscle Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261623003P | 2012-04-11 | 2012-04-11 | |
| US201261646842P | 2012-05-14 | 2012-05-14 | |
| US201261693061P | 2012-08-24 | 2012-08-24 | |
| US201261735809P | 2012-12-11 | 2012-12-11 | |
| PCT/US2013/036114 WO2013155262A2 (en) | 2012-04-11 | 2013-04-11 | Methods for improving resistance to skeletal muscle fatigue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL234886A true IL234886A (en) | 2017-02-28 |
Family
ID=49328282
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL234886A IL234886A (en) | 2012-04-11 | 2014-09-29 | Troponin activators for myocardial muscle, the compositions containing them, and their use in drug production |
| IL250473A IL250473A0 (en) | 2012-04-11 | 2017-02-06 | Troponin activators for skeletal muscle, the compositions containing them, and their use in the manufacture of drugs |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL250473A IL250473A0 (en) | 2012-04-11 | 2017-02-06 | Troponin activators for skeletal muscle, the compositions containing them, and their use in the manufacture of drugs |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20150250784A1 (enExample) |
| EP (1) | EP2836590A4 (enExample) |
| JP (2) | JP6352244B2 (enExample) |
| KR (1) | KR102163931B1 (enExample) |
| CN (2) | CN104395458A (enExample) |
| AU (3) | AU2013245917A1 (enExample) |
| BR (1) | BR112014025251B1 (enExample) |
| CA (1) | CA2869675C (enExample) |
| EA (1) | EA032480B1 (enExample) |
| HK (1) | HK1206389A1 (enExample) |
| IL (2) | IL234886A (enExample) |
| MX (1) | MX2014012179A (enExample) |
| PH (1) | PH12014502286A1 (enExample) |
| SG (2) | SG10201704166RA (enExample) |
| WO (1) | WO2013155262A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| EP2560488B1 (en) | 2010-04-23 | 2015-10-28 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| CN109316480A (zh) | 2011-07-13 | 2019-02-12 | 赛特凯恩蒂克公司 | 组合als疗法 |
| CA2903979A1 (en) | 2013-03-14 | 2014-09-18 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| LT3137622T (lt) * | 2014-04-29 | 2022-04-25 | Cytokinetics, Inc. | Gyvybinio pajėgumo nykimo mažinimo būdai |
| BR112017003745A2 (pt) | 2014-08-29 | 2017-12-05 | Tes Pharma S R L | inibidores de semialdeído descarboxilase de ácido alfa-amino-beta-carboximucônico |
| US9987279B2 (en) * | 2014-09-09 | 2018-06-05 | Astellas Pharma Inc. | Pharmaceutical composition for prevention and/or treatment of urinary incontinence |
| SG11201806416XA (en) | 2016-02-12 | 2018-08-30 | Astellas Pharma Inc | Tetrahydroisoquinoline derivatives |
| US10906888B2 (en) | 2016-07-14 | 2021-02-02 | Pfizer Inc. | Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme |
| US10357493B2 (en) | 2017-03-10 | 2019-07-23 | Selenity Therapeutics (Bermuda), Ltd. | Metalloenzyme inhibitor compounds |
| MX2022000947A (es) | 2019-07-23 | 2022-04-26 | Amorphical Ltd | Carbonato de calcio amorfo para mejorar el rendimiento deportivo. |
| CN114727974A (zh) | 2019-07-30 | 2022-07-08 | 艾科尼佐治疗股份有限公司 | Hdac6抑制剂及其用途 |
| JP7825618B2 (ja) | 2020-11-06 | 2026-03-06 | サイトキネティックス， インコーポレイテッド | 二環式１，４－ジアゼパノン及びその治療的使用 |
| WO2022169985A1 (en) | 2021-02-03 | 2022-08-11 | Eikonizo Therapeutics, Inc. | Hdac6 inhibitors and uses thereof |
| TW202329937A (zh) | 2021-12-03 | 2023-08-01 | 美商英塞特公司 | 雙環胺ｃｋ１２抑制劑 |
| US12084453B2 (en) | 2021-12-10 | 2024-09-10 | Incyte Corporation | Bicyclic amines as CDK12 inhibitors |
| AU2023250964A1 (en) | 2022-04-08 | 2024-11-07 | Eikonizo Therapeutics, Inc. | Oxadiazole hdac6 inhibitors and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005139081A (ja) * | 2003-11-04 | 2005-06-02 | Takada Seiyaku Kk | ビントペロール含有製剤 |
| US8227603B2 (en) * | 2006-08-01 | 2012-07-24 | Cytokinetics, Inc. | Modulating skeletal muscle |
| US8299248B2 (en) * | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| CN101522681B (zh) * | 2006-08-02 | 2012-10-03 | 赛特凯恩蒂克公司 | 特定的化学个体、组合物和方法 |
| CA2713864A1 (en) * | 2008-02-04 | 2009-08-13 | Cytokinetics, Incorporated | Certain chemical entities, compositions and methods |
| AR081331A1 (es) * | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| WO2013151938A1 (en) * | 2012-04-02 | 2013-10-10 | Cytokinetics, Inc. | Methods for improving diaphragm function |
-
2013
- 2013-04-11 BR BR112014025251-3A patent/BR112014025251B1/pt not_active IP Right Cessation
- 2013-04-11 CA CA2869675A patent/CA2869675C/en active Active
- 2013-04-11 SG SG10201704166RA patent/SG10201704166RA/en unknown
- 2013-04-11 HK HK15106995.5A patent/HK1206389A1/xx unknown
- 2013-04-11 JP JP2015505896A patent/JP6352244B2/ja not_active Expired - Fee Related
- 2013-04-11 EA EA201491666A patent/EA032480B1/ru not_active IP Right Cessation
- 2013-04-11 MX MX2014012179A patent/MX2014012179A/es unknown
- 2013-04-11 CN CN201380019567.7A patent/CN104395458A/zh active Pending
- 2013-04-11 WO PCT/US2013/036114 patent/WO2013155262A2/en not_active Ceased
- 2013-04-11 US US14/391,087 patent/US20150250784A1/en not_active Abandoned
- 2013-04-11 SG SG11201406359TA patent/SG11201406359TA/en unknown
- 2013-04-11 KR KR1020147028128A patent/KR102163931B1/ko not_active Expired - Fee Related
- 2013-04-11 CN CN202010369880.5A patent/CN111840294A/zh active Pending
- 2013-04-11 EP EP13775275.4A patent/EP2836590A4/en not_active Ceased
- 2013-04-11 AU AU2013245917A patent/AU2013245917A1/en not_active Abandoned
-
2014
- 2014-09-29 IL IL234886A patent/IL234886A/en active IP Right Grant
- 2014-10-10 PH PH12014502286A patent/PH12014502286A1/en unknown
-
2017
- 2017-02-06 IL IL250473A patent/IL250473A0/en unknown
- 2017-12-28 JP JP2017253312A patent/JP6535727B2/ja not_active Expired - Fee Related
-
2018
- 2018-02-08 AU AU2018200930A patent/AU2018200930A1/en not_active Abandoned
- 2018-11-30 US US16/206,747 patent/US20190167676A1/en not_active Abandoned
-
2019
- 2019-11-22 AU AU2019268177A patent/AU2019268177A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR102163931B1 (ko) | 2020-10-12 |
| SG11201406359TA (en) | 2014-11-27 |
| CN111840294A (zh) | 2020-10-30 |
| WO2013155262A2 (en) | 2013-10-17 |
| CA2869675A1 (en) | 2013-10-17 |
| BR112014025251B1 (pt) | 2021-03-02 |
| CA2869675C (en) | 2022-06-14 |
| PH12014502286B1 (en) | 2014-12-15 |
| EA201491666A1 (ru) | 2015-03-31 |
| JP6352244B2 (ja) | 2018-07-04 |
| KR20160046694A (ko) | 2016-04-29 |
| CN104395458A (zh) | 2015-03-04 |
| JP2015516392A (ja) | 2015-06-11 |
| JP6535727B2 (ja) | 2019-06-26 |
| JP2018048209A (ja) | 2018-03-29 |
| EP2836590A4 (en) | 2016-04-13 |
| WO2013155262A3 (en) | 2013-12-27 |
| US20190167676A1 (en) | 2019-06-06 |
| IL250473A0 (en) | 2017-03-30 |
| AU2019268177A1 (en) | 2019-12-12 |
| SG10201704166RA (en) | 2017-06-29 |
| MX2014012179A (es) | 2015-07-14 |
| HK1206389A1 (en) | 2016-01-08 |
| PH12014502286A1 (en) | 2014-12-15 |
| EA032480B1 (ru) | 2019-06-28 |
| EP2836590A2 (en) | 2015-02-18 |
| AU2013245917A1 (en) | 2014-10-23 |
| AU2018200930A1 (en) | 2018-03-01 |
| US20150250784A1 (en) | 2015-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |