IL234007A0 - Systemic delivery and regulated expression of paracrine genes for cardiovascular disease and other conditions - Google Patents

Systemic delivery and regulated expression of paracrine genes for cardiovascular disease and other conditions

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Publication number
IL234007A0
IL234007A0 IL234007A IL23400714A IL234007A0 IL 234007 A0 IL234007 A0 IL 234007A0 IL 234007 A IL234007 A IL 234007A IL 23400714 A IL23400714 A IL 23400714A IL 234007 A0 IL234007 A0 IL 234007A0
Authority
IL
Israel
Prior art keywords
paracrine
genes
conditions
cardiovascular diseases
systemic delivery
Prior art date
Application number
IL234007A
Other languages
English (en)
Hebrew (he)
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of IL234007A0 publication Critical patent/IL234007A0/en

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • C12N15/861Adenoviral vectors
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01DNA viruses
    • C07K14/075Adenoviridae
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    • C07KPEPTIDES
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/57509Corticotropin releasing factor [CRF] (Urotensin)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/65Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K38/22Hormones
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/2242Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/25Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/30Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2750/14011Parvoviridae
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    • C12N2830/003Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible

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IL234007A 2012-02-14 2014-08-07 Systemic delivery and regulated expression of paracrine genes for cardiovascular disease and other conditions IL234007A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261598772P 2012-02-14 2012-02-14
PCT/US2013/025997 WO2013123094A2 (en) 2012-02-14 2013-02-13 Systemic delivery and regulated expression of paracrine genes for cardiovascular diseases and other conditions

Publications (1)

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IL234007A0 true IL234007A0 (en) 2014-09-30

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Family Applications (3)

Application Number Title Priority Date Filing Date
IL234007A IL234007A0 (en) 2012-02-14 2014-08-07 Systemic delivery and regulated expression of paracrine genes for cardiovascular disease and other conditions
IL261172A IL261172A (en) 2012-02-14 2018-08-15 Systemic delivery and regulated expression of paracrine genes for cardiovascular disease and other conditions
IL26260018A IL262600B (en) 2012-02-14 2018-10-25 Vectors and their medical uses

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL261172A IL261172A (en) 2012-02-14 2018-08-15 Systemic delivery and regulated expression of paracrine genes for cardiovascular disease and other conditions
IL26260018A IL262600B (en) 2012-02-14 2018-10-25 Vectors and their medical uses

Country Status (18)

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US (3) US20150118287A1 (OSRAM)
EP (2) EP3311830A1 (OSRAM)
JP (3) JP6562632B2 (OSRAM)
KR (1) KR102107482B1 (OSRAM)
CN (2) CN104220098B (OSRAM)
AU (2) AU2013221615B2 (OSRAM)
BR (1) BR112014020127A2 (OSRAM)
CA (1) CA2864100A1 (OSRAM)
DK (1) DK2814513T3 (OSRAM)
ES (1) ES2660492T3 (OSRAM)
HK (1) HK1254639A1 (OSRAM)
HU (1) HUE036640T2 (OSRAM)
IL (3) IL234007A0 (OSRAM)
IN (1) IN2014DN06789A (OSRAM)
PL (1) PL2814513T3 (OSRAM)
PT (1) PT2814513T (OSRAM)
RU (1) RU2642605C2 (OSRAM)
WO (1) WO2013123094A2 (OSRAM)

Families Citing this family (32)

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Publication number Priority date Publication date Assignee Title
WO2010138263A2 (en) 2009-05-28 2010-12-02 University Of Massachusetts Novel aav 's and uses thereof
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