IL230754A0 - Fibroblastic growth factor 21 variants - Google Patents
Fibroblastic growth factor 21 variantsInfo
- Publication number
- IL230754A0 IL230754A0 IL230754A IL23075414A IL230754A0 IL 230754 A0 IL230754 A0 IL 230754A0 IL 230754 A IL230754 A IL 230754A IL 23075414 A IL23075414 A IL 23075414A IL 230754 A0 IL230754 A0 IL 230754A0
- Authority
- IL
- Israel
- Prior art keywords
- variants
- growth factor
- fibroblast growth
- fibroblast
- factor
- Prior art date
Links
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 title 1
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161542906P | 2011-10-04 | 2011-10-04 | |
| PCT/US2012/057053 WO2013052311A1 (en) | 2011-10-04 | 2012-09-25 | Fibroblast growth factor 21 variants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL230754A0 true IL230754A0 (en) | 2014-03-31 |
Family
ID=46964112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL230754A IL230754A0 (en) | 2011-10-04 | 2014-01-30 | Fibroblastic growth factor 21 variants |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US8541369B2 (en:Method) |
| EP (1) | EP2763689B1 (en:Method) |
| JP (1) | JP6060167B2 (en:Method) |
| KR (1) | KR20140059271A (en:Method) |
| CN (1) | CN103906530B (en:Method) |
| AP (1) | AP2014007532A0 (en:Method) |
| AR (1) | AR087973A1 (en:Method) |
| AU (1) | AU2012318956A1 (en:Method) |
| BR (1) | BR112014007532A2 (en:Method) |
| CA (1) | CA2843520A1 (en:Method) |
| CL (1) | CL2014000801A1 (en:Method) |
| CO (1) | CO6910165A2 (en:Method) |
| CR (1) | CR20140142A (en:Method) |
| DO (1) | DOP2014000050A (en:Method) |
| EA (1) | EA201490521A1 (en:Method) |
| EC (1) | ECSP14013285A (en:Method) |
| ES (1) | ES2548214T3 (en:Method) |
| IL (1) | IL230754A0 (en:Method) |
| IN (1) | IN2014CN00782A (en:Method) |
| MA (1) | MA35458B1 (en:Method) |
| MX (1) | MX2014004159A (en:Method) |
| PE (1) | PE20142044A1 (en:Method) |
| PH (1) | PH12014500740A1 (en:Method) |
| SG (1) | SG11201401792UA (en:Method) |
| TN (1) | TN2014000096A1 (en:Method) |
| TW (1) | TWI461435B (en:Method) |
| WO (1) | WO2013052311A1 (en:Method) |
| ZA (1) | ZA201400882B (en:Method) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2068909B1 (en) | 2007-03-30 | 2012-04-25 | Ambrx, Inc. | Modified fgf-21 polypeptides and their uses |
| DK2726511T3 (da) | 2011-07-01 | 2019-09-23 | Ngm Biopharmaceuticals Inc | Sammensætninger, anvendelser og fremgangsmåder til behandling af stofskiftesygdomme og -lidelser |
| EA201491856A1 (ru) * | 2012-05-15 | 2015-03-31 | Эли Лилли Энд Компани | Терапевтическое применение белков фактора роста фибробластов 21 |
| EP2859014B1 (en) * | 2012-06-11 | 2017-04-26 | Eli Lilly and Company | Fibroblast growth factor 21 variants |
| TWI513705B (zh) * | 2012-06-11 | 2015-12-21 | Lilly Co Eli | 纖維母細胞生長因子２１蛋白質 |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| CA2892152A1 (en) | 2012-11-28 | 2014-06-05 | Ngm Biopharmaceuticals, Inc. | Compositions and methods for treatment of metabolic disorders and diseases |
| CA2895517C (en) | 2012-12-27 | 2022-10-11 | Ngm Biopharmaceuticals, Inc. | Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| BR112016009099A2 (pt) | 2013-10-28 | 2017-09-19 | Ngm Biopharmaceuticals Inc | Método para determinar se um indivíduo de teste tendo um distúrbio metabólico é um candidato para o tratamento com uma variante de fgf19, método para determinar se uma variante de fgf19 é um candidato para tratar um indivíduo de teste, uso de uma variante fgf19, modelo para determinar se uma variante de fgf19 é um candidato para prevenir uma doença |
| UA119863C2 (uk) | 2014-01-24 | 2019-08-27 | Нгм Біофармасьютікалс, Інк. | Антитіло або його фрагмент, що зв'язується з бета-клото |
| WO2015138278A1 (en) * | 2014-03-11 | 2015-09-17 | Novartis Ag | Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling |
| WO2015183890A2 (en) | 2014-05-28 | 2015-12-03 | Ngm Biopharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders and diseases |
| EP3155005A4 (en) | 2014-06-16 | 2018-07-11 | NGM Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| EP3209681B1 (en) | 2014-10-23 | 2025-04-02 | NGM Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising peptide variants and methods of use thereof |
| CN114805533A (zh) | 2014-10-24 | 2022-07-29 | 百时美施贵宝公司 | 修饰的fgf-21多肽及其用途 |
| US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| WO2017019957A2 (en) | 2015-07-29 | 2017-02-02 | Ngm Biopharmaceuticals, Inc. | Binding proteins and methods of use thereof |
| CA3082794A1 (en) | 2015-11-09 | 2017-05-18 | Ngm Biopharmaceuticals Inc. | Methods for treatment of bile acid-related disorders |
| TW201731867A (zh) * | 2015-12-02 | 2017-09-16 | 賽諾菲公司 | Ｆｇｆ２１變異體 |
| WO2017220706A1 (en) * | 2016-06-22 | 2017-12-28 | Novo Nordisk A/S | Pharmaceutical compositions of fgf21 derivatives and uses thereof |
| CA3034399A1 (en) | 2016-08-26 | 2018-03-01 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
| CN106432509B (zh) * | 2016-09-13 | 2019-05-21 | 河南师范大学 | 一种治疗代谢疾病的重组人成纤维细胞生长因子21融合蛋白及其制备方法和应用 |
| CN106220724B (zh) * | 2016-09-13 | 2019-10-11 | 河南师范大学 | 人成纤维细胞生长因子21重组蛋白及其制备方法和应用 |
| CN106397607A (zh) * | 2016-09-13 | 2017-02-15 | 河南师范大学 | 重组人成纤维细胞生长因子21融合蛋白及其在制备治疗代谢疾病药物中的应用 |
| EP4470551A3 (en) | 2017-03-14 | 2025-02-26 | Sunshine Lake Pharma Co., Ltd. | Dual-target fusion proteins comprising the fc portion of an immunoglobulin |
| JP2020533304A (ja) | 2017-09-08 | 2020-11-19 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 改変型線維芽細胞成長因子２１（ｆｇｆ−２１）を用いる非アルコール性脂肪性肝炎（ｎａｓｈ）の処置方法 |
| DK3727423T3 (da) | 2017-12-22 | 2024-06-24 | Novartis Ag | Behandling af metaboliske lidelser med FGF21-varianter |
| JP7475276B2 (ja) * | 2018-02-08 | 2024-04-26 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | Ｆｇｆ２１バリアント、融合タンパク質及びそれらの適用 |
| US12226451B2 (en) | 2018-07-03 | 2025-02-18 | Bristol-Myers Squibb Company | FGF-21 formulations |
| CN109836486B (zh) * | 2019-01-30 | 2020-09-08 | 北京双因生物科技有限公司 | 成纤维生长因子21变体、其融合蛋白及其用途 |
| WO2020177712A1 (en) * | 2019-03-05 | 2020-09-10 | Dongguan Hec Biopharmaceutical R&D Co., Ltd. | A polypeptide molecule and application thereof |
| CN114853908B (zh) | 2019-05-16 | 2024-06-07 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的融合蛋白 |
| JP7600244B2 (ja) | 2020-01-08 | 2024-12-16 | ブリストル－マイヤーズ スクイブ カンパニー | Ｆｇｆ－２１コンジュゲート製剤 |
| WO2021139744A1 (en) | 2020-01-11 | 2021-07-15 | Beijing Ql Biopharmaceutical Co., Ltd. | Conjugates of fusion proteins of glp-1 and fgf21 |
| EP4192495A1 (en) | 2020-08-07 | 2023-06-14 | Bristol-Myers Squibb Company | Fgf21 combined with ccr2/5 antagonists for the treatment of fibrosis |
| KR102495299B1 (ko) * | 2020-11-03 | 2023-02-06 | 토드제약 주식회사 | Fgf21의 열탄력성을 이용한 fgf21 생산 방법 |
| WO2022115597A1 (en) | 2020-11-25 | 2022-06-02 | Bristol-Myers Squibb Company | Methods of treating liver diseases |
| JP2024527613A (ja) | 2021-07-14 | 2024-07-25 | ベイジン キューエル バイオファーマシューティカル カンパニー，リミテッド | 代謝性障害のための融合ポリペプチド |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| US20040259780A1 (en) | 2001-07-30 | 2004-12-23 | Glasebrook Andrew Lawrence | Method for treating diabetes and obesity |
| CN1890371A (zh) * | 2003-12-10 | 2007-01-03 | 伊莱利利公司 | 成纤维细胞生长因子的21突变蛋白 |
| EP1789443A1 (en) | 2004-09-02 | 2007-05-30 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
| DE602005016946D1 (de) | 2004-09-02 | 2009-11-12 | Lilly Co Eli | Muteine des fibroblasten-wachstumsfaktors 21 |
| EP2068909B1 (en) | 2007-03-30 | 2012-04-25 | Ambrx, Inc. | Modified fgf-21 polypeptides and their uses |
| JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| WO2010065439A1 (en) * | 2008-12-05 | 2010-06-10 | Eli Lilly And Company | Variants of fibroblast growth factor 21 |
| CA2760674A1 (en) | 2009-05-05 | 2010-11-11 | Amgen Inc. | Fgf21 mutants and uses thereof |
| JO3469B1 (ar) | 2009-05-05 | 2020-07-05 | Amgen Inc | طافرات fgf21 واستخداماتها |
-
2012
- 2012-09-20 AR ARP120103466A patent/AR087973A1/es unknown
- 2012-09-21 TW TW101134800A patent/TWI461435B/zh not_active IP Right Cessation
- 2012-09-25 JP JP2014534596A patent/JP6060167B2/ja active Active
- 2012-09-25 EP EP12766847.3A patent/EP2763689B1/en active Active
- 2012-09-25 CN CN201280048530.2A patent/CN103906530B/zh not_active Expired - Fee Related
- 2012-09-25 ES ES12766847.3T patent/ES2548214T3/es active Active
- 2012-09-25 KR KR1020147008644A patent/KR20140059271A/ko not_active Withdrawn
- 2012-09-25 WO PCT/US2012/057053 patent/WO2013052311A1/en not_active Ceased
- 2012-09-25 SG SG11201401792UA patent/SG11201401792UA/en unknown
- 2012-09-25 AP AP2014007532A patent/AP2014007532A0/xx unknown
- 2012-09-25 IN IN782CHN2014 patent/IN2014CN00782A/en unknown
- 2012-09-25 CA CA2843520A patent/CA2843520A1/en not_active Abandoned
- 2012-09-25 PE PE2014000472A patent/PE20142044A1/es not_active Application Discontinuation
- 2012-09-25 BR BR112014007532A patent/BR112014007532A2/pt not_active IP Right Cessation
- 2012-09-25 PH PH1/2014/500740A patent/PH12014500740A1/en unknown
- 2012-09-25 EA EA201490521A patent/EA201490521A1/ru unknown
- 2012-09-25 US US13/626,308 patent/US8541369B2/en active Active
- 2012-09-25 MX MX2014004159A patent/MX2014004159A/es unknown
- 2012-09-25 AU AU2012318956A patent/AU2012318956A1/en not_active Abandoned
-
2013
- 2013-08-13 US US13/965,243 patent/US8883726B2/en active Active
-
2014
- 2014-01-30 IL IL230754A patent/IL230754A0/en unknown
- 2014-02-05 ZA ZA2014/00882A patent/ZA201400882B/en unknown
- 2014-03-06 TN TNP2014000096A patent/TN2014000096A1/en unknown
- 2014-03-06 DO DO2014000050A patent/DOP2014000050A/es unknown
- 2014-03-17 CO CO14057034A patent/CO6910165A2/es unknown
- 2014-03-27 MA MA36861A patent/MA35458B1/fr unknown
- 2014-03-27 CR CR20140142A patent/CR20140142A/es unknown
- 2014-04-02 CL CL2014000801A patent/CL2014000801A1/es unknown
- 2014-04-04 EC ECSP14013285 patent/ECSP14013285A/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201400882B (en) | Fibroblast growth factor 21 variants | |
| ZA201407938B (en) | Fibroblast growth factor 21 variants | |
| IL235832A0 (en) | Fibroblastic growth factor 21 proteins | |
| PL119929U1 (pl) | Konewka | |
| HK1196294A (en) | Fibroblast growth factor 21 variants | |
| GB201322227D0 (en) | Watering can | |
| PL119925U1 (pl) | Konewka | |
| PL119924U1 (pl) | Konewka | |
| PL119926U1 (pl) | Konewka | |
| PL119927U1 (pl) | Konewka | |
| PL119928U1 (pl) | Konewka | |
| GB201100366D0 (en) | Concept 12 12 | |
| GB201114519D0 (en) | Concept 31 | |
| GB201104316D0 (en) | Concept 60 | |
| GB201103885D0 (en) | Concept 58 | |
| GB201103884D0 (en) | Concept 59 | |
| GB201114472D0 (en) | Concept 14 | |
| GB201100371D0 (en) | Concept 15 | |
| GB201114478D0 (en) | Concept 11 | |
| GB201114480D0 (en) | Concept 9 | |
| GB201114544D0 (en) | Concept 25 | |
| GB201114486D0 (en) | Concept 6 | |
| GB201114487D0 (en) | Concept 16 | |
| GB201114489D0 (en) | Concept 12 12 | |
| GB201114502D0 (en) | Concept 53 |