MA35458B1 - Variants du facteur de croissance des fibroblastes 21 - Google Patents
Variants du facteur de croissance des fibroblastes 21Info
- Publication number
- MA35458B1 MA35458B1 MA36861A MA36861A MA35458B1 MA 35458 B1 MA35458 B1 MA 35458B1 MA 36861 A MA36861 A MA 36861A MA 36861 A MA36861 A MA 36861A MA 35458 B1 MA35458 B1 MA 35458B1
- Authority
- MA
- Morocco
- Prior art keywords
- variants
- growth factor
- fibroblast growth
- fgf21
- dyslipidemia
- Prior art date
Links
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 title abstract 3
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 title abstract 3
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 101000846529 Homo sapiens Fibroblast growth factor 21 Proteins 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 102000056713 human FGF21 Human genes 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention concerne des variants pharmacologiquement puissants et/ou stables du facteur de croissance 21 du fibroblaste humain (fgf21), des compositions pharmaceutiques comprenant des variants fgf21, ainsi que des procédés de traitement du diabète de type 2, l'obésité, la dyslipidémie, ou le syndrome métabolique, ou toute combinaison de ceux-ci, utilisant de tels variants.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161542906P | 2011-10-04 | 2011-10-04 | |
PCT/US2012/057053 WO2013052311A1 (fr) | 2011-10-04 | 2012-09-25 | Variants du facteur de croissance 21 du fibroblaste |
Publications (1)
Publication Number | Publication Date |
---|---|
MA35458B1 true MA35458B1 (fr) | 2014-09-01 |
Family
ID=46964112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA36861A MA35458B1 (fr) | 2011-10-04 | 2014-03-27 | Variants du facteur de croissance des fibroblastes 21 |
Country Status (27)
Country | Link |
---|---|
US (2) | US8541369B2 (fr) |
EP (1) | EP2763689B1 (fr) |
JP (1) | JP6060167B2 (fr) |
KR (1) | KR20140059271A (fr) |
CN (1) | CN103906530B (fr) |
AP (1) | AP2014007532A0 (fr) |
AR (1) | AR087973A1 (fr) |
AU (1) | AU2012318956A1 (fr) |
BR (1) | BR112014007532A2 (fr) |
CA (1) | CA2843520A1 (fr) |
CL (1) | CL2014000801A1 (fr) |
CO (1) | CO6910165A2 (fr) |
CR (1) | CR20140142A (fr) |
DO (1) | DOP2014000050A (fr) |
EA (1) | EA201490521A1 (fr) |
EC (1) | ECSP14013285A (fr) |
ES (1) | ES2548214T3 (fr) |
IL (1) | IL230754A0 (fr) |
IN (1) | IN2014CN00782A (fr) |
MA (1) | MA35458B1 (fr) |
MX (1) | MX2014004159A (fr) |
PE (1) | PE20142044A1 (fr) |
SG (1) | SG11201401792UA (fr) |
TN (1) | TN2014000096A1 (fr) |
TW (1) | TWI461435B (fr) |
WO (1) | WO2013052311A1 (fr) |
ZA (1) | ZA201400882B (fr) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2682147C (fr) | 2007-03-30 | 2017-08-08 | Ambrx, Inc. | Polypeptides fgf-21 modifies, et leurs utilisations |
US8951966B2 (en) | 2011-07-01 | 2015-02-10 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides, and uses and methods thereof for treatment of metabolic disorders and diseases |
EP2852398A1 (fr) * | 2012-05-15 | 2015-04-01 | Eli Lilly and Company | Utilisations thérapeutiques de protéines de facteur de croissance des fibroblastes 21 |
TWI513705B (zh) | 2012-06-11 | 2015-12-21 | Lilly Co Eli | 纖維母細胞生長因子21蛋白質 |
EP2859014B1 (fr) | 2012-06-11 | 2017-04-26 | Eli Lilly and Company | Variants du facteur de croissance 21 du fibroblaste |
EP2925775B1 (fr) | 2012-11-28 | 2020-09-16 | NGM Biopharmaceuticals, Inc. | Compositions et méthodes de traitement de troubles et maladies métaboliques |
US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
CN105008548B (zh) | 2012-12-27 | 2020-11-27 | 恩格姆生物制药公司 | 用于调节胆汁酸体内稳态以及治疗胆汁酸紊乱和疾病的方法 |
BR112016009099A2 (pt) | 2013-10-28 | 2017-09-19 | Ngm Biopharmaceuticals Inc | Método para determinar se um indivíduo de teste tendo um distúrbio metabólico é um candidato para o tratamento com uma variante de fgf19, método para determinar se uma variante de fgf19 é um candidato para tratar um indivíduo de teste, uso de uma variante fgf19, modelo para determinar se uma variante de fgf19 é um candidato para prevenir uma doença |
ES2808340T3 (es) | 2014-01-24 | 2021-02-26 | Ngm Biopharmaceuticals Inc | Anticuerpos que se unen al dominio de beta klotho 2 y procedimientos de uso de los mismos |
EP3125921B1 (fr) | 2014-03-11 | 2020-07-08 | Novartis AG | Variants de fgf21 pour l'utilisation dans le traitement de la lipodystrophie partielle indue par arv/sida |
US10398758B2 (en) | 2014-05-28 | 2019-09-03 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions |
WO2015195509A2 (fr) | 2014-06-16 | 2015-12-23 | Ngm Biopharmaceuticals, Inc. | Procédés et utilisations pour la modulation de l'homéostasie de l'acide biliaire et le traitement de troubles et maladies de l'acide biliaire |
MX2017004488A (es) | 2014-10-23 | 2017-07-17 | Ngm Biopharmaceuticals Inc | Composiciones farmaceuticas que comprenden variantes peptidicos y metodos para su uso. |
TW202124419A (zh) | 2014-10-24 | 2021-07-01 | 美商必治妥美雅史谷比公司 | 經修飾之fgf-21多肽及其用途 |
WO2016073855A1 (fr) | 2014-11-07 | 2016-05-12 | Ngm Biopharmaceuticals, Inc. | Procédés de traitement de troubles liés à l'acide biliaire et prédiction de la sensibilité clinique au traitement de troubles liés aux acides biliaires |
WO2017019957A2 (fr) | 2015-07-29 | 2017-02-02 | Ngm Biopharmaceuticals, Inc. | Protéines de liaison et leurs procédés d'utilisation |
CA3082794A1 (fr) | 2015-11-09 | 2017-05-18 | Ngm Biopharmaceuticals Inc. | Methodes de traitement de troubles associes aux acides biliaires |
TW201731867A (zh) * | 2015-12-02 | 2017-09-16 | 賽諾菲公司 | Fgf21變異體 |
WO2017220706A1 (fr) * | 2016-06-22 | 2017-12-28 | Novo Nordisk A/S | Compositions pharmaceutiques de dérivés de fgf21 et leurs utilisations |
WO2018039557A1 (fr) | 2016-08-26 | 2018-03-01 | Ngm Biopharmaceuticals, Inc. | Méthodes de traitement de cancers et de tumeurs à médiation assurée par le facteur de croissance des fibroblastes 19 |
CN106220724B (zh) * | 2016-09-13 | 2019-10-11 | 河南师范大学 | 人成纤维细胞生长因子21重组蛋白及其制备方法和应用 |
CN106397607A (zh) * | 2016-09-13 | 2017-02-15 | 河南师范大学 | 重组人成纤维细胞生长因子21融合蛋白及其在制备治疗代谢疾病药物中的应用 |
CN106432509B (zh) * | 2016-09-13 | 2019-05-21 | 河南师范大学 | 一种治疗代谢疾病的重组人成纤维细胞生长因子21融合蛋白及其制备方法和应用 |
CN108570109B (zh) * | 2017-03-14 | 2022-04-26 | 广东东阳光药业有限公司 | 包含免疫球蛋白Fc部分的双靶点融合蛋白 |
WO2019051073A1 (fr) | 2017-09-08 | 2019-03-14 | Bristol-Myers Squibb Company | Facteur de croissance des fibroblastes 21 (fgf-21) modifié destiné à une utilisation dans des méthodes de traitement de la stéatohépatite non alcoolique (nash) |
WO2019154189A1 (fr) * | 2018-02-08 | 2019-08-15 | Sunshine Lake Pharma Co., Ltd. | Variant de fgf21, protéine de fusion et son application |
JP7492463B2 (ja) * | 2018-07-03 | 2024-05-29 | ブリストル-マイヤーズ スクイブ カンパニー | Fgf-21製剤 |
CN109836486B (zh) * | 2019-01-30 | 2020-09-08 | 北京双因生物科技有限公司 | 成纤维生长因子21变体、其融合蛋白及其用途 |
CN114853908B (zh) | 2019-05-16 | 2024-06-07 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的融合蛋白 |
AU2021205912A1 (en) | 2020-01-08 | 2022-07-28 | Bristol-Myers Squibb Company | FGF-21 conjugate formulations |
CN115322794A (zh) | 2020-01-11 | 2022-11-11 | 北京质肽生物医药科技有限公司 | Glp-1和fgf21的融合蛋白的缀合物 |
JP2023538533A (ja) | 2020-08-07 | 2023-09-08 | ブリストル-マイヤーズ スクイブ カンパニー | 線維症の処置のための、ccr2/5拮抗剤と組み合わせたfgf21 |
KR102495299B1 (ko) * | 2020-11-03 | 2023-02-06 | 토드제약 주식회사 | Fgf21의 열탄력성을 이용한 fgf21 생산 방법 |
US20240123031A1 (en) | 2020-11-25 | 2024-04-18 | Bristol-Myers Squibb Company | Methods of treating liver diseases |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
AU2002322394A1 (en) | 2001-07-30 | 2003-02-17 | Eli Lilly And Company | Method for treating diabetes and obesity |
US7491697B2 (en) * | 2003-12-10 | 2009-02-17 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
WO2006028595A2 (fr) | 2004-09-02 | 2006-03-16 | Eli Lilly And Company | Muteines de facteur de croissance 21 de fibroblaste |
WO2006028714A1 (fr) | 2004-09-02 | 2006-03-16 | Eli Lilly And Company | Muteines du facteur de croissance 21 du fibroblaste |
CA2682147C (fr) | 2007-03-30 | 2017-08-08 | Ambrx, Inc. | Polypeptides fgf-21 modifies, et leurs utilisations |
JOP20190083A1 (ar) * | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
WO2010065439A1 (fr) * | 2008-12-05 | 2010-06-10 | Eli Lilly And Company | Variants de facteurde croissance 21 du fibroblaste |
EP2427207B1 (fr) | 2009-05-05 | 2017-08-16 | Amgen, Inc | Mutants de fgf21 et leurs utilisations |
PE20160718A1 (es) | 2009-05-05 | 2016-08-03 | Amgen Inc | Polipeptidos mutantes fgf21 |
-
2012
- 2012-09-20 AR ARP120103466A patent/AR087973A1/es unknown
- 2012-09-21 TW TW101134800A patent/TWI461435B/zh not_active IP Right Cessation
- 2012-09-25 AP AP2014007532A patent/AP2014007532A0/xx unknown
- 2012-09-25 CA CA2843520A patent/CA2843520A1/fr not_active Abandoned
- 2012-09-25 WO PCT/US2012/057053 patent/WO2013052311A1/fr active Application Filing
- 2012-09-25 AU AU2012318956A patent/AU2012318956A1/en not_active Abandoned
- 2012-09-25 CN CN201280048530.2A patent/CN103906530B/zh not_active Expired - Fee Related
- 2012-09-25 ES ES12766847.3T patent/ES2548214T3/es active Active
- 2012-09-25 JP JP2014534596A patent/JP6060167B2/ja active Active
- 2012-09-25 SG SG11201401792UA patent/SG11201401792UA/en unknown
- 2012-09-25 MX MX2014004159A patent/MX2014004159A/es unknown
- 2012-09-25 KR KR1020147008644A patent/KR20140059271A/ko not_active Application Discontinuation
- 2012-09-25 IN IN782CHN2014 patent/IN2014CN00782A/en unknown
- 2012-09-25 EP EP12766847.3A patent/EP2763689B1/fr active Active
- 2012-09-25 US US13/626,308 patent/US8541369B2/en active Active
- 2012-09-25 EA EA201490521A patent/EA201490521A1/ru unknown
- 2012-09-25 PE PE2014000472A patent/PE20142044A1/es not_active Application Discontinuation
- 2012-09-25 BR BR112014007532A patent/BR112014007532A2/pt not_active IP Right Cessation
-
2013
- 2013-08-13 US US13/965,243 patent/US8883726B2/en active Active
-
2014
- 2014-01-30 IL IL230754A patent/IL230754A0/en unknown
- 2014-02-05 ZA ZA2014/00882A patent/ZA201400882B/en unknown
- 2014-03-06 TN TNP2014000096A patent/TN2014000096A1/en unknown
- 2014-03-06 DO DO2014000050A patent/DOP2014000050A/es unknown
- 2014-03-17 CO CO14057034A patent/CO6910165A2/es unknown
- 2014-03-27 MA MA36861A patent/MA35458B1/fr unknown
- 2014-03-27 CR CR20140142A patent/CR20140142A/es unknown
- 2014-04-02 CL CL2014000801A patent/CL2014000801A1/es unknown
- 2014-04-04 EC ECSP14013285 patent/ECSP14013285A/es unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA35458B1 (fr) | Variants du facteur de croissance des fibroblastes 21 | |
EA201492053A1 (ru) | Белки фактора роста фибробластов 21 | |
CY1119596T1 (el) | Σταθερη φαρμακευτικη συνθεση και μεθοδοι χρησης αυτης | |
EA201492064A1 (ru) | Варианты фактора роста фибробластов 21 | |
EA201290964A1 (ru) | Пептидные конъюгаты агонистов рецептора glp-1 и их применение | |
EA200901032A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr119 | |
EA201390060A1 (ru) | Аннелированные пиримидины и триазины и их применение для лечения и/или профилактики сердечно-сосудистых заболеваний | |
EA201100138A1 (ru) | 4-феноксиметилпиперидины в качестве модуляторов активности gpr119 | |
EA201290209A1 (ru) | Новые модуляторы бензопиран киназы | |
EA201101190A1 (ru) | Фармацевтическая композиция, включающая линаглиптин и необязательно ингибитор sglt2, и ее применение | |
EA201001639A1 (ru) | Композиции и способы их получения и применения | |
EA200901166A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr 119 | |
EA201291336A1 (ru) | Замещенные 5-фтор-1н-пиразолопиридины и их применение | |
CL2009000349A1 (es) | Compuestos derivados de 4,5-dihidro-oxazol-2-ilamina; procedimiento de preparacion; composicion farmaceutica; y su uso para el tratamiento de la enfermedad de alzheimer. | |
EA201270480A1 (ru) | Новые соединения | |
EA201190217A1 (ru) | Замещенные 2-ацетамидо-5-арил-1,2,4-триазолоны и их применение | |
EA201200551A1 (ru) | Фармацевтическая композиция, фармацевтическая дозированная форма, способы их получения и применения для лечения | |
EA201100691A1 (ru) | Антагонисты рецепторов лизофосфатидной кислоты | |
AR080685A1 (es) | Composiciones de anticuerpos anti-factor de crecimiento nervioso (ngf) | |
EA201100032A1 (ru) | Соединения пиридина | |
CR20130264A (es) | Compuestos pirimidinona para uso en el tratamiento de enfermedades o condiciones mediadas por lp-pla2 | |
EA201300471A1 (ru) | Замещенные 6-аминоникотинамиды в качестве модуляторов kcnq2/3 | |
EA201200570A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr119 | |
EA201400623A1 (ru) | Новые 2h-индазолы в качестве антагонистов рецептора ep | |
CY1116234T1 (el) | Υποκατεστημενα 2-οξυ-κινολινο-3-καρβοξαμιδια σαν διαμορφωτες kcnq2/3 |