IL225118A - Cytokines as biomarkers predicting clinical response to glutiramer acetate - Google Patents
Cytokines as biomarkers predicting clinical response to glutiramer acetateInfo
- Publication number
- IL225118A IL225118A IL225118A IL22511813A IL225118A IL 225118 A IL225118 A IL 225118A IL 225118 A IL225118 A IL 225118A IL 22511813 A IL22511813 A IL 22511813A IL 225118 A IL225118 A IL 225118A
- Authority
- IL
- Israel
- Prior art keywords
- human subject
- glatiramer acetate
- pharmaceutical composition
- concentration
- multiple sclerosis
- Prior art date
Links
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- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/525—Tumor necrosis factor [TNF]
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- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
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- G01N2333/55—IL-2
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- G—PHYSICS
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/555—Interferons [IFN]
- G01N2333/57—IFN-gamma
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/285—Demyelinating diseases; Multipel sclerosis
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- G—PHYSICS
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- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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| US39196810P | 2010-10-11 | 2010-10-11 | |
| PCT/US2011/055588 WO2012051106A1 (en) | 2010-10-11 | 2011-10-10 | Cytokine biomarkers as predictive biomarkers of clinical response for glatiramer acetate |
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| EP (1) | EP2627669B1 (OSRAM) |
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| UA103699C2 (ru) | 2009-08-20 | 2013-11-11 | Еда Рисёрч Энд Девелопмент Ко., Лтд. | Терапия глатирамера ацетатом с низкой частотой |
| USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| EA025780B1 (ru) | 2010-10-11 | 2017-01-30 | Тева Фармасьютикал Индастриз Лтд. | Цитокиновые биомаркеры в качестве биомаркеров, прогнозирующих клинический ответ на глатирамер ацетат |
| CA2851510A1 (en) | 2011-10-10 | 2013-04-18 | Teva Pharmaceutical Industries Ltd. | Single nucleotide polymorphisms useful to predict clinical response for glatiramer acetate |
| TW201420111A (zh) | 2012-10-10 | 2014-06-01 | Teva Pharma | 對格拉默醋酸鹽（ｇｌａｔｉｒａｍｅｒ ａｃｅｔａｔｅ）之臨床反應具預測性之生物標記 |
| US10344330B2 (en) | 2013-03-14 | 2019-07-09 | Mylan Inc. | Glatiramer acetate response biomarker mRNA potency assay |
| UY35790A (es) | 2013-10-21 | 2015-05-29 | Teva Pharma | Marcadores genéticos que predicen la respuesta al acetato de glatiramer |
| TWI717314B (zh) | 2013-10-24 | 2021-02-01 | 美商麥蘭股份有限公司 | 供評估格拉默醋酸鹽製備物之免疫同一性用的人類ｔ細胞株分析方法 |
| US9155775B1 (en) | 2015-01-28 | 2015-10-13 | Teva Pharmaceutical Industries, Ltd. | Process for manufacturing glatiramer acetate product |
| US20160213633A1 (en) * | 2015-01-28 | 2016-07-28 | Teva Pharmaceutical Industries, Ltd. | Method of inducing anti-glatiramer acetate antibody response |
| US12097292B2 (en) | 2016-08-28 | 2024-09-24 | Mapi Pharma Ltd. | Process for preparing microparticles containing glatiramer acetate |
| US12370233B2 (en) | 2016-08-31 | 2025-07-29 | Mapi Pharma Ltd. | Depot systems comprising glatiramer acetate |
| WO2018178973A1 (en) | 2017-03-26 | 2018-10-04 | Mapi Pharma Ltd. | Glatiramer depot systems for treating progressive forms of multiple sclerosis |
| KR102734078B1 (ko) * | 2018-08-30 | 2024-11-25 | 싸토리우스 바이오애널리티컬 인스트루먼츠, 아이엔씨 | 단일 샘플 중 저농도 및 고농도 단백질의 농도 결정 방법 |
| WO2025181335A1 (en) * | 2024-02-29 | 2025-09-04 | Grifols Worldwide Operations Limited | Methods of treating a cognitive impairment |
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| EA025780B1 (ru) | 2010-10-11 | 2017-01-30 | Тева Фармасьютикал Индастриз Лтд. | Цитокиновые биомаркеры в качестве биомаркеров, прогнозирующих клинический ответ на глатирамер ацетат |
| CA2851510A1 (en) | 2011-10-10 | 2013-04-18 | Teva Pharmaceutical Industries Ltd. | Single nucleotide polymorphisms useful to predict clinical response for glatiramer acetate |
| TW201420111A (zh) | 2012-10-10 | 2014-06-01 | Teva Pharma | 對格拉默醋酸鹽（ｇｌａｔｉｒａｍｅｒ ａｃｅｔａｔｅ）之臨床反應具預測性之生物標記 |
| KR20150111918A (ko) | 2012-12-21 | 2015-10-06 | 테바 파마슈티컬 인더스트리즈 리미티드 | 글라티라머 아세테이트의 경점막 전달 |
| EA201591187A1 (ru) | 2012-12-21 | 2016-03-31 | Тева Фармасьютикал Индастриз Лтд. | Пероральная трансмукозальная доставка ацетата глатирамера |
| BR112015016169A2 (pt) | 2013-01-04 | 2017-07-11 | Teva Pharma | caracterizando produtos de drogas relacionados a acetato de glatirâmero |
| BR112015022538A2 (pt) | 2013-03-12 | 2017-07-18 | Teva Pharma | terapia de indução de rituximab seguida por terapia de acetato de glatirâmero |
| UY35790A (es) | 2013-10-21 | 2015-05-29 | Teva Pharma | Marcadores genéticos que predicen la respuesta al acetato de glatiramer |
| US9155775B1 (en) | 2015-01-28 | 2015-10-13 | Teva Pharmaceutical Industries, Ltd. | Process for manufacturing glatiramer acetate product |
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| US9625473B2 (en) | 2017-04-18 |
| EA025780B1 (ru) | 2017-01-30 |
| NZ703122A (en) | 2016-06-24 |
| MX347871B (es) | 2017-05-16 |
| EA201390543A1 (ru) | 2013-09-30 |
| EP2627669A4 (en) | 2014-04-09 |
| AU2011313842B2 (en) | 2016-12-15 |
| US20120121619A1 (en) | 2012-05-17 |
| US9063153B2 (en) | 2015-06-23 |
| PL2627669T3 (pl) | 2017-02-28 |
| WO2012051106A1 (en) | 2012-04-19 |
| KR20140019296A (ko) | 2014-02-14 |
| US20150241446A1 (en) | 2015-08-27 |
| EP2627669A1 (en) | 2013-08-21 |
| AU2011313842A1 (en) | 2013-05-30 |
| JP2013541010A (ja) | 2013-11-07 |
| US20140294899A1 (en) | 2014-10-02 |
| BR112013008573A2 (pt) | 2016-07-12 |
| US8709433B2 (en) | 2014-04-29 |
| NZ609938A (en) | 2015-11-27 |
| ES2602977T3 (es) | 2017-02-23 |
| EP2627669B1 (en) | 2016-08-17 |
| JP2016188214A (ja) | 2016-11-04 |
| MX2013003929A (es) | 2013-07-05 |
| PT2627669T (pt) | 2016-11-24 |
| CA2814500A1 (en) | 2012-04-19 |
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